EA201201405A1 - Способ получения гидрохинонов - Google Patents

Способ получения гидрохинонов

Info

Publication number
EA201201405A1
EA201201405A1 EA201201405A EA201201405A EA201201405A1 EA 201201405 A1 EA201201405 A1 EA 201201405A1 EA 201201405 A EA201201405 A EA 201201405A EA 201201405 A EA201201405 A EA 201201405A EA 201201405 A1 EA201201405 A1 EA 201201405A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrochinons
obtaining
formula
relates
hydroxybenzaldehyde
Prior art date
Application number
EA201201405A
Other languages
English (en)
Other versions
EA022721B1 (ru
Inventor
Шахурадж Ханамантрао Кадам
Шашикумар Пакникар
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201201405A1 publication Critical patent/EA201201405A1/ru
Publication of EA022721B1 publication Critical patent/EA022721B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C07C37/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms by replacing a carboxyl or aldehyde group by a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение относится к способу получения соединения гидрохинона формулы (I)в которой R2, R3, R5 и R6 имеют значения по п.1, с стадиями формилирования замещённого фенола и оксидирования получившегося замещённого 4-гидроксибензальдегида в кислых условиях до соответствующего гидрохинона формулы (I). Другая задача изобретения касается промежуточного соединения 2,3,5-триметил-4-гидроксибензальдегида для синтеза 2,3,5-триметилгидрохинона (TMHQ) и (dl)α-токоферола.
EA201201405A 2010-04-15 2011-03-17 Способ получения гидрохинонов EA022721B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10003959 2010-04-15
PCT/EP2011/001316 WO2011128018A1 (en) 2010-04-15 2011-03-17 Process for the preparation of hydroquinones

Publications (2)

Publication Number Publication Date
EA201201405A1 true EA201201405A1 (ru) 2013-04-30
EA022721B1 EA022721B1 (ru) 2016-02-29

Family

ID=44041683

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201405A EA022721B1 (ru) 2010-04-15 2011-03-17 Способ получения гидрохинонов

Country Status (10)

Country Link
US (1) US8846982B2 (ru)
EP (1) EP2558433B1 (ru)
JP (1) JP5778755B2 (ru)
CN (1) CN102844286B (ru)
AU (1) AU2011240367B2 (ru)
BR (1) BR112012025343A2 (ru)
EA (1) EA022721B1 (ru)
ES (1) ES2496093T3 (ru)
WO (1) WO2011128018A1 (ru)
ZA (1) ZA201208583B (ru)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833660A (en) * 1972-04-26 1974-09-03 Gen Electric Process for making aromatic aldehydes
FR2486523A1 (fr) * 1980-07-11 1982-01-15 Rhone Poulenc Ind Procede de preparation de polyphenols comportant eventuellement un groupement aldehyde
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
ZA9010041B (en) * 1989-12-21 1992-08-26 Lilly Co Eli Compounds for treating inflammatory bowel disease
ES2099338T3 (es) * 1992-10-09 1997-05-16 Hoechst Ag Oxidacion de hidroxi-benzaldehidos para la preparacion de compuestos de dihidroxi-benceno.
DE59305736D1 (de) 1992-11-20 1997-04-17 Hoechst Ag Verfahren zur selektiven Herstellung von Hydroxybenzaldehyden
US5324860A (en) 1993-10-27 1994-06-28 Sepracor, Inc. Process for 3,5-di-tert-butylsalicylaldehyde
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
WO2003027111A1 (en) * 2001-09-27 2003-04-03 Smithkline Beecham Corporation Chemical compounds
WO2006018954A1 (ja) * 2004-08-17 2006-02-23 Eisai R & D Management Co., Ltd. ジブロモフルオロベンゼン誘導体の製造方法
US8143424B2 (en) * 2007-06-06 2012-03-27 Torrent Pharmaceuticals Ltd. Thyroid like compounds
AU2009220861B2 (en) * 2008-03-07 2014-05-29 Idorsia Pharmaceuticals Ltd Pyridin-2-YL derivatives as immunomodulating agents
DE102009002514A1 (de) * 2009-04-21 2010-10-28 Evonik Degussa Gmbh Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden

Also Published As

Publication number Publication date
AU2011240367A1 (en) 2012-11-29
ES2496093T3 (es) 2014-09-18
BR112012025343A2 (pt) 2016-06-28
JP2013523848A (ja) 2013-06-17
US20130211149A1 (en) 2013-08-15
JP5778755B2 (ja) 2015-09-16
WO2011128018A1 (en) 2011-10-20
ZA201208583B (en) 2013-09-25
EA022721B1 (ru) 2016-02-29
CN102844286A (zh) 2012-12-26
AU2011240367B2 (en) 2015-07-16
CN102844286B (zh) 2014-12-31
EP2558433A1 (en) 2013-02-20
US8846982B2 (en) 2014-09-30
EP2558433B1 (en) 2014-06-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU