CL2012000493A1 - Procedimiento de preparacion de 2-alquilamino-3-piridin-n-bencilpiperazin cetonas. - Google Patents
Procedimiento de preparacion de 2-alquilamino-3-piridin-n-bencilpiperazin cetonas.Info
- Publication number
- CL2012000493A1 CL2012000493A1 CL2012000493A CL2012000493A CL2012000493A1 CL 2012000493 A1 CL2012000493 A1 CL 2012000493A1 CL 2012000493 A CL2012000493 A CL 2012000493A CL 2012000493 A CL2012000493 A CL 2012000493A CL 2012000493 A1 CL2012000493 A1 CL 2012000493A1
- Authority
- CL
- Chile
- Prior art keywords
- benzylpiperazine
- alkylamino
- ketones
- pyridine
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un método para sintetizar un compuesto derivado de piperazina disustituida con bencilo y ácido nicotínico, útiles para el tratamiento de condiciones neurológicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23647709P | 2009-08-24 | 2009-08-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2012000493A1 true CL2012000493A1 (es) | 2012-09-28 |
Family
ID=43649584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2012000493A CL2012000493A1 (es) | 2009-08-24 | 2012-02-24 | Procedimiento de preparacion de 2-alquilamino-3-piridin-n-bencilpiperazin cetonas. |
Country Status (23)
Country | Link |
---|---|
US (2) | US9278933B2 (es) |
EP (1) | EP2470182B1 (es) |
JP (1) | JP5727482B2 (es) |
KR (1) | KR101701362B1 (es) |
CN (2) | CN105693601A (es) |
AU (1) | AU2010289802C1 (es) |
BR (1) | BR112012004161B1 (es) |
CA (1) | CA2772080C (es) |
CL (1) | CL2012000493A1 (es) |
DK (1) | DK2470182T3 (es) |
ES (1) | ES2475721T3 (es) |
HK (1) | HK1172844A1 (es) |
HR (1) | HRP20140621T1 (es) |
IL (1) | IL218298A (es) |
IN (1) | IN2012DN02370A (es) |
MX (1) | MX2012002335A (es) |
NZ (1) | NZ598891A (es) |
PL (1) | PL2470182T3 (es) |
PT (1) | PT2470182E (es) |
RU (1) | RU2567390C2 (es) |
SG (1) | SG178867A1 (es) |
SI (1) | SI2470182T1 (es) |
WO (1) | WO2011028548A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105693601A (zh) * | 2009-08-24 | 2016-06-22 | 纽若斯丹公司 | 神经刺激性哌嗪的合成 |
JP7204640B2 (ja) * | 2016-09-12 | 2023-01-16 | ニューラルステム・インコーポレーテッド | 糖尿病に関連する神経障害の改善 |
US20180104240A1 (en) * | 2016-10-18 | 2018-04-19 | Neuralstem, Inc. | Amelioration of radiation-induced cognitive dysfunction |
US10042957B2 (en) | 2017-01-12 | 2018-08-07 | Innovationdock, Inc. | Devices and methods for implementing dynamic collaborative workflow systems |
US10413534B2 (en) * | 2017-02-13 | 2019-09-17 | Neuralstem, Inc. | Amelioration of certain deficiencies due to stroke |
US20240067625A1 (en) * | 2020-12-23 | 2024-02-29 | Baylor College Of Medicine | Small-molecule modulators of the orphan nuclear receptor tlx |
CA3219364A1 (en) | 2021-06-03 | 2022-12-08 | Alto Neuroscience, Inc. | Method of treatment of depressed patients with poor cognition and selection of other patients benefiting from a benzylpiperazine-aminopyridine agent |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU175075B (hu) * | 1977-06-30 | 1980-05-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija piperazidov piridin-karbonovoj kisloty |
JPS54122283A (en) * | 1978-03-13 | 1979-09-21 | Sumitomo Chem Co Ltd | Novel quinazoline derivative and its preparation |
US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
DE60330323D1 (de) * | 2002-03-29 | 2010-01-14 | Schering Corp | Stereoselektive alkylierung von chirale 2-methyl-4-geschützte piperazinen |
GB0222493D0 (en) * | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
CA2537292C (en) * | 2003-09-09 | 2013-04-02 | F. Hoffmann-La Roche Ag | 1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
NZ554441A (en) * | 2004-10-29 | 2009-07-31 | Banyu Pharma Co Ltd | Novel aminopyridine derivatives having aurora A selective inhibitory action |
US7754724B2 (en) | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
WO2007071358A1 (en) * | 2005-12-20 | 2007-06-28 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutamate receptors |
CN105693601A (zh) * | 2009-08-24 | 2016-06-22 | 纽若斯丹公司 | 神经刺激性哌嗪的合成 |
-
2010
- 2010-08-24 CN CN201511009541.1A patent/CN105693601A/zh active Pending
- 2010-08-24 CA CA2772080A patent/CA2772080C/en active Active
- 2010-08-24 EP EP10814260.5A patent/EP2470182B1/en active Active
- 2010-08-24 AU AU2010289802A patent/AU2010289802C1/en active Active
- 2010-08-24 SG SG2012012878A patent/SG178867A1/en unknown
- 2010-08-24 BR BR112012004161A patent/BR112012004161B1/pt active IP Right Grant
- 2010-08-24 SI SI201030669T patent/SI2470182T1/sl unknown
- 2010-08-24 CN CN2010800465155A patent/CN102711764A/zh active Pending
- 2010-08-24 JP JP2012526928A patent/JP5727482B2/ja active Active
- 2010-08-24 US US13/392,489 patent/US9278933B2/en active Active
- 2010-08-24 DK DK10814260.5T patent/DK2470182T3/da active
- 2010-08-24 ES ES10814260.5T patent/ES2475721T3/es active Active
- 2010-08-24 MX MX2012002335A patent/MX2012002335A/es active IP Right Grant
- 2010-08-24 WO PCT/US2010/046537 patent/WO2011028548A1/en active Application Filing
- 2010-08-24 IN IN2370DEN2012 patent/IN2012DN02370A/en unknown
- 2010-08-24 PL PL10814260T patent/PL2470182T3/pl unknown
- 2010-08-24 PT PT108142605T patent/PT2470182E/pt unknown
- 2010-08-24 KR KR1020127007653A patent/KR101701362B1/ko active IP Right Grant
- 2010-08-24 NZ NZ598891A patent/NZ598891A/en not_active IP Right Cessation
- 2010-08-24 RU RU2012111227/04A patent/RU2567390C2/ru not_active IP Right Cessation
-
2012
- 2012-02-23 IL IL218298A patent/IL218298A/en active IP Right Grant
- 2012-02-24 CL CL2012000493A patent/CL2012000493A1/es unknown
-
2013
- 2013-01-04 HK HK13100159.2A patent/HK1172844A1/xx unknown
-
2014
- 2014-06-30 HR HRP20140621AT patent/HRP20140621T1/hr unknown
-
2015
- 2015-12-09 US US14/964,397 patent/US9481649B2/en active Active
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