BR112012004161A2 - síntese de uma piperazina neuroestimulativa - Google Patents
síntese de uma piperazina neuroestimulativaInfo
- Publication number
- BR112012004161A2 BR112012004161A2 BR112012004161A BR112012004161A BR112012004161A2 BR 112012004161 A2 BR112012004161 A2 BR 112012004161A2 BR 112012004161 A BR112012004161 A BR 112012004161A BR 112012004161 A BR112012004161 A BR 112012004161A BR 112012004161 A2 BR112012004161 A2 BR 112012004161A2
- Authority
- BR
- Brazil
- Prior art keywords
- neurostimulative
- piperazine
- synthesis
- neurostimulative piperazine
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23647709P | 2009-08-24 | 2009-08-24 | |
| PCT/US2010/046537 WO2011028548A1 (en) | 2009-08-24 | 2010-08-24 | Synthesis of a neurostimulative piperazine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012004161A2 true BR112012004161A2 (pt) | 2016-03-29 |
| BR112012004161B1 BR112012004161B1 (pt) | 2020-04-07 |
Family
ID=43649584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004161A BR112012004161B1 (pt) | 2009-08-24 | 2010-08-24 | método para sintetizar uma piperazina neuroestimulativa |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9278933B2 (pt) |
| EP (1) | EP2470182B1 (pt) |
| JP (1) | JP5727482B2 (pt) |
| KR (1) | KR101701362B1 (pt) |
| CN (2) | CN105693601A (pt) |
| AU (1) | AU2010289802C1 (pt) |
| BR (1) | BR112012004161B1 (pt) |
| CA (1) | CA2772080C (pt) |
| CL (1) | CL2012000493A1 (pt) |
| DK (1) | DK2470182T3 (pt) |
| ES (1) | ES2475721T3 (pt) |
| HK (1) | HK1172844A1 (pt) |
| HR (1) | HRP20140621T1 (pt) |
| IL (1) | IL218298A (pt) |
| IN (1) | IN2012DN02370A (pt) |
| MX (1) | MX2012002335A (pt) |
| NZ (1) | NZ598891A (pt) |
| PL (1) | PL2470182T3 (pt) |
| PT (1) | PT2470182E (pt) |
| RU (1) | RU2567390C2 (pt) |
| SG (1) | SG178867A1 (pt) |
| SI (1) | SI2470182T1 (pt) |
| WO (1) | WO2011028548A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2567390C2 (ru) * | 2009-08-24 | 2015-11-10 | Ньюралстем, Инк. | Получение нейростимулирующего пиперазина |
| JP7204640B2 (ja) * | 2016-09-12 | 2023-01-16 | ニューラルステム・インコーポレーテッド | 糖尿病に関連する神経障害の改善 |
| US20180104240A1 (en) * | 2016-10-18 | 2018-04-19 | Neuralstem, Inc. | Amelioration of radiation-induced cognitive dysfunction |
| US10042957B2 (en) | 2017-01-12 | 2018-08-07 | Innovationdock, Inc. | Devices and methods for implementing dynamic collaborative workflow systems |
| US10413534B2 (en) * | 2017-02-13 | 2019-09-17 | Neuralstem, Inc. | Amelioration of certain deficiencies due to stroke |
| US20240067625A1 (en) * | 2020-12-23 | 2024-02-29 | Baylor College Of Medicine | Small-molecule modulators of the orphan nuclear receptor tlx |
| WO2022256636A2 (en) | 2021-06-03 | 2022-12-08 | Alto Neuroscience, Inc. | Method of treatment of depressed patients with poor cognition and selection of other patients benefiting from a benzylpiperazine-aminopyridine agent |
| WO2024123695A1 (en) | 2022-12-05 | 2024-06-13 | Alto Neuroscience, Inc. | Effective treatment of depression in patients having impaired learning and/or memory or certain eeg characteristics with a benzylpiperazine-aminopyridine agent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU175075B (hu) * | 1977-06-30 | 1980-05-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija piperazidov piridin-karbonovoj kisloty |
| JPS54122283A (en) * | 1978-03-13 | 1979-09-21 | Sumitomo Chem Co Ltd | Novel quinazoline derivative and its preparation |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| ES2335488T3 (es) * | 2002-03-29 | 2010-03-29 | Schering Corporation | Alquilacion estereoselectiva de piperazinas quirales 2-metil-4-protegidas. |
| GB0222493D0 (en) * | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
| US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
| WO2005023260A1 (en) * | 2003-09-09 | 2005-03-17 | F. Hoffmann-La Roche Ag | 1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
| JP4973190B2 (ja) * | 2004-10-29 | 2012-07-11 | Ｍｓｄ株式会社 | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US7754724B2 (en) * | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
| US20090005363A1 (en) * | 2005-12-20 | 2009-01-01 | Ralf Glatthar | Organic Compounds |
| RU2567390C2 (ru) * | 2009-08-24 | 2015-11-10 | Ньюралстем, Инк. | Получение нейростимулирующего пиперазина |
-
2010
- 2010-08-24 RU RU2012111227/04A patent/RU2567390C2/ru not_active IP Right Cessation
- 2010-08-24 JP JP2012526928A patent/JP5727482B2/ja active Active
- 2010-08-24 WO PCT/US2010/046537 patent/WO2011028548A1/en active Application Filing
- 2010-08-24 EP EP10814260.5A patent/EP2470182B1/en active Active
- 2010-08-24 ES ES10814260.5T patent/ES2475721T3/es active Active
- 2010-08-24 CA CA2772080A patent/CA2772080C/en active Active
- 2010-08-24 PT PT108142605T patent/PT2470182E/pt unknown
- 2010-08-24 AU AU2010289802A patent/AU2010289802C1/en active Active
- 2010-08-24 PL PL10814260T patent/PL2470182T3/pl unknown
- 2010-08-24 MX MX2012002335A patent/MX2012002335A/es active IP Right Grant
- 2010-08-24 KR KR1020127007653A patent/KR101701362B1/ko active IP Right Grant
- 2010-08-24 SI SI201030669T patent/SI2470182T1/sl unknown
- 2010-08-24 BR BR112012004161A patent/BR112012004161B1/pt active IP Right Grant
- 2010-08-24 DK DK10814260.5T patent/DK2470182T3/da active
- 2010-08-24 SG SG2012012878A patent/SG178867A1/en unknown
- 2010-08-24 CN CN201511009541.1A patent/CN105693601A/zh active Pending
- 2010-08-24 IN IN2370DEN2012 patent/IN2012DN02370A/en unknown
- 2010-08-24 NZ NZ598891A patent/NZ598891A/en not_active IP Right Cessation
- 2010-08-24 CN CN2010800465155A patent/CN102711764A/zh active Pending
- 2010-08-24 US US13/392,489 patent/US9278933B2/en active Active
-
2012
- 2012-02-23 IL IL218298A patent/IL218298A/en active IP Right Grant
- 2012-02-24 CL CL2012000493A patent/CL2012000493A1/es unknown
-
2013
- 2013-01-04 HK HK13100159.2A patent/HK1172844A1/xx unknown
-
2014
- 2014-06-30 HR HRP20140621AT patent/HRP20140621T1/hr unknown
-
2015
- 2015-12-09 US US14/964,397 patent/US9481649B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS. |