DK2470182T3 - Syntese af en neurostimulerende piperazin - Google Patents
Syntese af en neurostimulerende piperazinInfo
- Publication number
- DK2470182T3 DK2470182T3 DK10814260.5T DK10814260T DK2470182T3 DK 2470182 T3 DK2470182 T3 DK 2470182T3 DK 10814260 T DK10814260 T DK 10814260T DK 2470182 T3 DK2470182 T3 DK 2470182T3
- Authority
- DK
- Denmark
- Prior art keywords
- neurostimulating
- piperazine
- synthesis
- neurostimulating piperazine
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23647709P | 2009-08-24 | 2009-08-24 | |
| PCT/US2010/046537 WO2011028548A1 (en) | 2009-08-24 | 2010-08-24 | Synthesis of a neurostimulative piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2470182T3 true DK2470182T3 (da) | 2014-07-21 |
Family
ID=43649584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10814260.5T DK2470182T3 (da) | 2009-08-24 | 2010-08-24 | Syntese af en neurostimulerende piperazin |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9278933B2 (da) |
| EP (1) | EP2470182B1 (da) |
| JP (1) | JP5727482B2 (da) |
| KR (1) | KR101701362B1 (da) |
| CN (2) | CN105693601A (da) |
| AU (1) | AU2010289802C1 (da) |
| BR (1) | BR112012004161B1 (da) |
| CA (1) | CA2772080C (da) |
| CL (1) | CL2012000493A1 (da) |
| DK (1) | DK2470182T3 (da) |
| ES (1) | ES2475721T3 (da) |
| HK (1) | HK1172844A1 (da) |
| HR (1) | HRP20140621T1 (da) |
| IL (1) | IL218298A (da) |
| IN (1) | IN2012DN02370A (da) |
| MX (1) | MX2012002335A (da) |
| NZ (1) | NZ598891A (da) |
| PL (1) | PL2470182T3 (da) |
| PT (1) | PT2470182E (da) |
| RU (1) | RU2567390C2 (da) |
| SG (1) | SG178867A1 (da) |
| SI (1) | SI2470182T1 (da) |
| WO (1) | WO2011028548A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011028548A1 (en) * | 2009-08-24 | 2011-03-10 | Neuralstem, Inc. | Synthesis of a neurostimulative piperazine |
| CA3036571C (en) * | 2016-09-12 | 2023-10-03 | Neuralstem, Inc. | Amelioration of neural deficits associated with diabetes |
| WO2018075667A1 (en) * | 2016-10-18 | 2018-04-26 | Neuralstem, Inc. | Amelioration of radiation-induced cognitive dysfunction |
| US10042957B2 (en) | 2017-01-12 | 2018-08-07 | Innovationdock, Inc. | Devices and methods for implementing dynamic collaborative workflow systems |
| WO2018148733A1 (en) * | 2017-02-13 | 2018-08-16 | Neuralstem, Inc. | Amelioration of certain deficiencies due to stroke |
| EP4267561A1 (en) * | 2020-12-23 | 2023-11-01 | Baylor College of Medicine | Small-molecule modulators of the orphan nuclear receptor tlx |
| BR112023025330A2 (pt) | 2021-06-03 | 2024-02-27 | Alto Neuroscience Inc | Método de tratamento de pacientes deprimidos com cognição fraca e seleção de outros pacientes beneficiados com agente benzilpiperazina-aminopiridina |
| WO2024123695A1 (en) | 2022-12-05 | 2024-06-13 | Alto Neuroscience, Inc. | Effective treatment of depression in patients having impaired learning and/or memory or certain eeg characteristics with a benzylpiperazine-aminopyridine agent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU175075B (hu) * | 1977-06-30 | 1980-05-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija piperazidov piridin-karbonovoj kisloty |
| JPS54122283A (en) * | 1978-03-13 | 1979-09-21 | Sumitomo Chem Co Ltd | Novel quinazoline derivative and its preparation |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| EP2141153A3 (en) * | 2002-03-29 | 2010-05-26 | Schering Corporation | Stereoselective alkylation of chiral 2-methyl-4 protected piperazines |
| GB0222493D0 (en) * | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
| US20040185429A1 (en) * | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
| MXPA06002727A (es) * | 2003-09-09 | 2006-06-05 | Hoffmann La Roche | Derivados de 1-(2-amino-benzol)-piperazina como inhibidores de la captacion de glicina para el tratamiento de psicosis. |
| PE20060600A1 (es) * | 2004-10-29 | 2006-07-14 | Banyu Pharma Co Ltd | Derivados de aminopiridina como inhibidores selectivos de la aurora a quinasa |
| US7754724B2 (en) * | 2005-06-30 | 2010-07-13 | Dow Agrosciences Llc | N-substituted piperazines |
| KR20080076962A (ko) * | 2005-12-20 | 2008-08-20 | 노파르티스 아게 | 대사성 글루타메이트 수용체 조절제로서의 니코틴산 유도체 |
| WO2011028548A1 (en) * | 2009-08-24 | 2011-03-10 | Neuralstem, Inc. | Synthesis of a neurostimulative piperazine |
-
2010
- 2010-08-24 WO PCT/US2010/046537 patent/WO2011028548A1/en active Application Filing
- 2010-08-24 US US13/392,489 patent/US9278933B2/en active Active
- 2010-08-24 AU AU2010289802A patent/AU2010289802C1/en active Active
- 2010-08-24 PL PL10814260T patent/PL2470182T3/pl unknown
- 2010-08-24 JP JP2012526928A patent/JP5727482B2/ja active Active
- 2010-08-24 NZ NZ598891A patent/NZ598891A/en not_active IP Right Cessation
- 2010-08-24 CN CN201511009541.1A patent/CN105693601A/zh active Pending
- 2010-08-24 KR KR1020127007653A patent/KR101701362B1/ko active IP Right Grant
- 2010-08-24 PT PT108142605T patent/PT2470182E/pt unknown
- 2010-08-24 DK DK10814260.5T patent/DK2470182T3/da active
- 2010-08-24 BR BR112012004161A patent/BR112012004161B1/pt active IP Right Grant
- 2010-08-24 RU RU2012111227/04A patent/RU2567390C2/ru not_active IP Right Cessation
- 2010-08-24 EP EP10814260.5A patent/EP2470182B1/en active Active
- 2010-08-24 IN IN2370DEN2012 patent/IN2012DN02370A/en unknown
- 2010-08-24 ES ES10814260.5T patent/ES2475721T3/es active Active
- 2010-08-24 MX MX2012002335A patent/MX2012002335A/es active IP Right Grant
- 2010-08-24 CN CN2010800465155A patent/CN102711764A/zh active Pending
- 2010-08-24 CA CA2772080A patent/CA2772080C/en active Active
- 2010-08-24 SG SG2012012878A patent/SG178867A1/en unknown
- 2010-08-24 SI SI201030669T patent/SI2470182T1/sl unknown
-
2012
- 2012-02-23 IL IL218298A patent/IL218298A/en active IP Right Grant
- 2012-02-24 CL CL2012000493A patent/CL2012000493A1/es unknown
-
2013
- 2013-01-04 HK HK13100159.2A patent/HK1172844A1/xx unknown
-
2014
- 2014-06-30 HR HRP20140621AT patent/HRP20140621T1/hr unknown
-
2015
- 2015-12-09 US US14/964,397 patent/US9481649B2/en active Active
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