EA201190191A1 - Изотиазоло-пиримидинедионовые производные в качестве модуляторов trpa1 - Google Patents

Изотиазоло-пиримидинедионовые производные в качестве модуляторов trpa1

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Publication number
EA201190191A1
EA201190191A1 EA201190191A EA201190191A EA201190191A1 EA 201190191 A1 EA201190191 A1 EA 201190191A1 EA 201190191 A EA201190191 A EA 201190191A EA 201190191 A EA201190191 A EA 201190191A EA 201190191 A1 EA201190191 A1 EA 201190191A1
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Eurasian Patent Office
Prior art keywords
trpa1
isothiazolo
pyrimidinedione
modulators
pyrimidinedione derivatives
Prior art date
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EA201190191A
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English (en)
Inventor
Сукеерти Кумар
Абрахам Томас
Санджей Маргал
Неелима Кхайраткар-Джоши
Индранил Мухопадхяй
Original Assignee
Гленмарк Фармасьютикалс, С.А.
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Publication date
Application filed by Гленмарк Фармасьютикалс, С.А. filed Critical Гленмарк Фармасьютикалс, С.А.
Publication of EA201190191A1 publication Critical patent/EA201190191A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Данное изобретение касается новых производных изотиазол[3,4-d]пиримидиндиона и изотиазол[5,4-d]пиримидиндиона в качестве модуляторов TRPA (рецептор транзиторного потенциала, подсемейство А). В частности, описанные здесь соединения полезны для лечения или профилактики заболеваний, состояний и/или расстройств, модулируемых TRPA1 (рецептор транзиторного потенциала, подсемейство А, 1 член). Описываются также способы получения описываемых здесь соединений, используемые в их синтезе промежуточные соединения, фармацевтические композиции на их основе и способы лечения заболеваний, состояний и/или расстройств, модулируемых TRPA1.
EA201190191A 2009-03-23 2010-03-22 Изотиазоло-пиримидинедионовые производные в качестве модуляторов trpa1 EA201190191A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN665MU2009 2009-03-23
US17135509P 2009-04-21 2009-04-21
PCT/IB2010/000834 WO2010109328A1 (en) 2009-03-23 2010-03-22 Isothiazolo-pyrimidinedione derivatives as trpa1 modulators

Publications (1)

Publication Number Publication Date
EA201190191A1 true EA201190191A1 (ru) 2012-11-30

Family

ID=42236291

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190191A EA201190191A1 (ru) 2009-03-23 2010-03-22 Изотиазоло-пиримидинедионовые производные в качестве модуляторов trpa1

Country Status (23)

Country Link
US (1) US8575178B2 (ru)
EP (1) EP2411397B1 (ru)
JP (1) JP2012521405A (ru)
KR (1) KR20120001746A (ru)
CN (1) CN102395592A (ru)
AP (1) AP2011005888A0 (ru)
AU (1) AU2010227224A1 (ru)
BR (1) BRPI1009372A2 (ru)
CA (1) CA2756534A1 (ru)
DK (1) DK2411397T3 (ru)
EA (1) EA201190191A1 (ru)
ES (1) ES2424340T3 (ru)
HK (1) HK1166081A1 (ru)
IL (1) IL215179A0 (ru)
MX (1) MX2011009821A (ru)
PE (1) PE20120764A1 (ru)
PL (1) PL2411397T3 (ru)
PT (1) PT2411397E (ru)
SG (2) SG184766A1 (ru)
SI (1) SI2411397T1 (ru)
UA (1) UA107342C2 (ru)
WO (1) WO2010109328A1 (ru)
ZA (1) ZA201107646B (ru)

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PT2411395E (pt) 2009-03-23 2013-06-06 Glenmark Pharmaceuticals Sa Derivados de furopirimidinadiona como moduladores de trpa1
ES2456515T3 (es) 2009-03-23 2014-04-22 Glenmark Pharmaceuticals S.A. Derivados de pirimidindiona fusionados como moduladores de TRPA1
AP3391A (en) 2010-12-20 2015-08-31 Glenmark Pharmaceuticals Sa 2-Amino-4-arylthiazole compounds as TROA1 antagonists
EP2520566A1 (en) 2011-05-06 2012-11-07 Orion Corporation New Pharmaceutical Compounds
CA2836856A1 (en) 2011-06-13 2012-12-20 Glenmark Pharmaceuticals, S.A. Treatment of respiratory disorders using trpa1 antagonists
WO2012176105A1 (en) 2011-06-22 2012-12-27 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
JP2014517062A (ja) 2011-06-22 2014-07-17 グレンマーク ファーマシューティカルズ， エセ．アー． ＴＲＰＡ１アンタゴニスト及びβ２アゴニストを含む医薬組成物
CA2841417A1 (en) 2011-07-25 2013-01-31 Glenmark Pharmaceuticals Sa Pharmaceutical composition comprising a trpa1 antagonist and a steroid
TWI640519B (zh) * 2011-11-29 2018-11-11 泰緯生命科技股份有限公司 Ｈｅｃ１活性調控因子及其調節方法
EP2787991A1 (en) 2011-12-05 2014-10-15 Glenmark Pharmaceuticals S.A. Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
CA2873570C (en) 2012-06-08 2016-11-01 Glenmark Pharmaceuticals S.A. Amides of 2-amino-4-arylthiazole compounds and their salts as trpa1 modulators
WO2014053694A1 (en) 2012-10-01 2014-04-10 Orion Corporation N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
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CN114656480B (zh) * 2022-04-27 2024-01-26 成都施贝康生物医药科技有限公司 噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途

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Publication number Publication date
BRPI1009372A2 (pt) 2016-05-31
US8575178B2 (en) 2013-11-05
SI2411397T1 (sl) 2013-07-31
PL2411397T3 (pl) 2013-10-31
US20120010223A1 (en) 2012-01-12
PT2411397E (pt) 2013-06-06
CN102395592A (zh) 2012-03-28
ES2424340T3 (es) 2013-10-01
PE20120764A1 (es) 2012-06-27
SG174403A1 (en) 2011-10-28
IL215179A0 (en) 2011-12-29
JP2012521405A (ja) 2012-09-13
AU2010227224A2 (en) 2011-10-27
WO2010109328A1 (en) 2010-09-30
SG184766A1 (en) 2012-10-30
MX2011009821A (es) 2012-01-25
CA2756534A1 (en) 2010-09-30
ZA201107646B (en) 2012-06-25
DK2411397T3 (da) 2013-08-05
AU2010227224A1 (en) 2011-09-29
KR20120001746A (ko) 2012-01-04
AP2011005888A0 (en) 2011-10-31
HK1166081A1 (en) 2012-10-19
EP2411397B1 (en) 2013-05-29
EP2411397A1 (en) 2012-02-01
UA107342C2 (en) 2014-12-25

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