EA201171451A1 - Генетические маркеры, ассоциированные с ответом на интерферон-альфа - Google Patents

Генетические маркеры, ассоциированные с ответом на интерферон-альфа

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Publication number
EA201171451A1
EA201171451A1 EA201171451A EA201171451A EA201171451A1 EA 201171451 A1 EA201171451 A1 EA 201171451A1 EA 201171451 A EA201171451 A EA 201171451A EA 201171451 A EA201171451 A EA 201171451A EA 201171451 A1 EA201171451 A1 EA 201171451A1
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EA
Eurasian Patent Office
Prior art keywords
ifn
response
genetic markers
interferon
alpha
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EA201171451A
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English (en)
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EA020795B1 (ru
Inventor
Артур Бертелсен
Жак Фелле
Дунлян Гэ
Дэвид Б. Голдстейн
Джон Г. Макхатчисон
Николас Дж. Мерголо
Пин Цю
Роберт Орвилл II Рэлстон
Кевин Шианна
Джейсон С. Саймон
Александер Дж. Томпсон
Томас Урбан
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Шеринг Корпорейшн
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Application filed by Шеринг Корпорейшн filed Critical Шеринг Корпорейшн
Publication of EA201171451A1 publication Critical patent/EA201171451A1/ru
Publication of EA020795B1 publication Critical patent/EA020795B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
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  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Immunology (AREA)
  • Biotechnology (AREA)
  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Mathematical Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Computational Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Mathematical Optimization (AREA)
  • Pure & Applied Mathematics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)

Abstract

Настоящее изобретение предоставляет генетические маркеры, расположенные на хромосоме 19 человека, которые ассоциированы с положительным ответом на интерферон-альфа (IFN-α). Указанные маркеры ответа на IFN-α являются полезными, помимо прочего, для выявления пациентов, на которых, по всей вероятности, окажет благоприятное действие лечение фармацевтическими композициями и лекарственными продуктами IFN-α, в способах лечения пациентов, имеющих заболевание, поддающееся лечению IFN-α, и в способах выбора наиболее подходящей терапии для таких пациентов.
EA201171451A 2009-05-21 2010-05-21 Генетические маркеры, ассоциированные с ответом на интерферон-альфа EA020795B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18032009P 2009-05-21 2009-05-21
US22316909P 2009-07-06 2009-07-06
US23254709P 2009-08-10 2009-08-10
PCT/US2010/035782 WO2010135649A1 (en) 2009-05-21 2010-05-21 Genetic markers associated with interferon-alpha response

Publications (2)

Publication Number Publication Date
EA201171451A1 true EA201171451A1 (ru) 2012-06-29
EA020795B1 EA020795B1 (ru) 2015-01-30

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Country Status (11)

Country Link
US (2) US8535887B2 (ru)
EP (1) EP2432898B1 (ru)
JP (3) JP5469744B2 (ru)
KR (1) KR20140014375A (ru)
CN (1) CN102459647B (ru)
AU (1) AU2010249379B2 (ru)
CA (1) CA2761125A1 (ru)
EA (1) EA020795B1 (ru)
MX (1) MX2011012311A (ru)
UA (1) UA106756C2 (ru)
WO (1) WO2010135649A1 (ru)

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JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
RU2641609C1 (ru) * 2017-04-10 2018-01-18 Елена Валериевна Мелехина Способ определения показаний к проведению противогерпетической терапии при инфекции ВГЧ-6 у детей с острыми респираторными заболеваниями
CN108220424A (zh) * 2018-02-05 2018-06-29 广州和康医疗技术有限公司 一种检测il28基因位点的方法及试剂盒
CN109504763B (zh) * 2018-12-17 2020-09-04 北京三元基因药业股份有限公司 用于预测α干扰素治疗乙肝患者疗效的分子标记
CN113088572A (zh) * 2021-05-25 2021-07-09 杭州方略生物科技有限公司 一种乙肝用药检测固相pcr试剂盒

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Also Published As

Publication number Publication date
CA2761125A1 (en) 2010-11-25
CN102459647B (zh) 2015-05-06
JP5469744B2 (ja) 2014-04-16
US8535887B2 (en) 2013-09-17
UA106756C2 (ru) 2014-10-10
MX2011012311A (es) 2011-12-14
US20130251677A1 (en) 2013-09-26
JP2012236844A (ja) 2012-12-06
AU2010249379A1 (en) 2011-12-08
JP2012527482A (ja) 2012-11-08
KR20140014375A (ko) 2014-02-06
EA020795B1 (ru) 2015-01-30
CN102459647A (zh) 2012-05-16
AU2010249379B2 (en) 2013-09-26
JP2014076051A (ja) 2014-05-01
EP2432898A1 (en) 2012-03-28
US20100297080A1 (en) 2010-11-25
EP2432898B1 (en) 2014-11-26
WO2010135649A1 (en) 2010-11-25

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