ATE525070T1 - Silbininkomponente zur behandlung von hepatitis - Google Patents

Silbininkomponente zur behandlung von hepatitis

Info

Publication number
ATE525070T1
ATE525070T1 AT08849759T AT08849759T ATE525070T1 AT E525070 T1 ATE525070 T1 AT E525070T1 AT 08849759 T AT08849759 T AT 08849759T AT 08849759 T AT08849759 T AT 08849759T AT E525070 T1 ATE525070 T1 AT E525070T1
Authority
AT
Austria
Prior art keywords
hepatitis
treatment
silbine
incomponent
ribavirin
Prior art date
Application number
AT08849759T
Other languages
English (en)
Inventor
Lucio Rovati
Amato Massimo D
Ulrich Mengs
Ralf-Torsten Pohl
Peter Ferenci
Original Assignee
Madaus Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Gmbh filed Critical Madaus Gmbh
Application granted granted Critical
Publication of ATE525070T1 publication Critical patent/ATE525070T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08849759T 2007-11-15 2008-11-14 Silbininkomponente zur behandlung von hepatitis ATE525070T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US98816807P 2007-11-15 2007-11-15
EP07022187 2007-11-15
EP08005459 2008-03-25
PCT/EP2008/009659 WO2009062737A1 (en) 2007-11-15 2008-11-14 Silibinin component for the treatment of hepatitis

Publications (1)

Publication Number Publication Date
ATE525070T1 true ATE525070T1 (de) 2011-10-15

Family

ID=40259958

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08849759T ATE525070T1 (de) 2007-11-15 2008-11-14 Silbininkomponente zur behandlung von hepatitis

Country Status (14)

Country Link
US (2) US20110182858A1 (de)
EP (2) EP2392326B9 (de)
JP (1) JP5349486B2 (de)
KR (1) KR101435242B1 (de)
CN (1) CN102300570B (de)
AT (1) ATE525070T1 (de)
AU (1) AU2008323156B2 (de)
CA (1) CA2703834C (de)
DK (1) DK2219642T3 (de)
ES (2) ES2662700T3 (de)
MX (1) MX2010005107A (de)
PL (2) PL2219642T3 (de)
PT (1) PT2219642E (de)
WO (1) WO2009062737A1 (de)

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Publication number Priority date Publication date Assignee Title
TWI529167B (zh) 2009-05-14 2016-04-11 歐羅梅德股份有限公司 用於治療病毒性肝炎之非晶型水飛薊賓
WO2011051742A1 (en) * 2009-10-28 2011-05-05 Modutech S.A. Preparation comprising amino acids and plants and its activity in the alcohol detoxification
SE1450130A1 (sv) 2011-10-21 2014-05-07 Abbvie Inc Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon
EP2583680A3 (de) 2011-10-21 2013-06-12 Abbvie Inc. Einzel- (PSI-7977) oder Kombinationsbehandlung in der Verwendung zur Behandlung von HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US20160324795A1 (en) * 2014-01-27 2016-11-10 Kaohsiung Medical University Silibinin nanoparticle and a method of treating hepatitis c thereof
EP3111484B1 (de) * 2014-02-26 2023-09-06 Commonwealth Scientific and Industrial Research Organisation Verfahren zur herstellung einer photoaktiven schicht einer photoaktiven perowskitvorrichtung
EP3203989B1 (de) 2014-10-09 2019-08-21 Distretto Tecnologico Sicilia Micro e Nano Sistemi S.C.A.R.L. Nanostrukturierte formulierungen zur verabreichung von silibinin und anderen wirkstoffen zur behandlung von augenerkrankungen
US20180280343A1 (en) * 2015-10-02 2018-10-04 Theresa PACHECO Topical silibinin formulations and uses therefor
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
JP6765273B2 (ja) * 2016-10-05 2020-10-07 株式会社ファンケル シリマリン粉砕物
CN111841501A (zh) * 2020-06-23 2020-10-30 五邑大学 一种治疗炎症性疾病的药物组合物及其应用
KR20230019398A (ko) * 2021-07-30 2023-02-08 경희대학교 산학협력단 항바이러스 조성물 및 이의 이용
CN117269374B (zh) * 2023-11-22 2024-01-16 汤臣倍健股份有限公司 一种水飞蓟提取物中人为掺假的鉴别方法
CN117919256B (zh) * 2024-03-25 2024-05-24 潍坊众邦制药有限公司 一种含有药用甾醇活性物质组合物在制备治疗肝炎的用途

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US4061765A (en) * 1973-01-19 1977-12-06 Dr. Madaus & Co. Polyhydroxyphenylchromanone salts and therapeutic composition
DE3442639A1 (de) * 1984-11-22 1986-05-22 Dr. Madaus & Co, 5000 Köln Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
DE3537656A1 (de) * 1984-11-22 1986-05-22 Dr. Madaus GmbH & Co, 5000 Köln Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin
IT1215291B (it) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
IT1241673B (it) 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
DE4401902C2 (de) * 1994-01-24 2000-02-03 Madaus Ag Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
US6555141B1 (en) * 1998-02-27 2003-04-29 Nutramax Laboratories, Inc. L-ergothioneine, Milk thistle, and S-adenosylmethionine for the prevention, treatment and repair of liver damage
WO1999055326A1 (en) * 1998-04-30 1999-11-04 Vit-Immune, L.C. Method of treatment of glutathione deficient mammals
CN1328463A (zh) * 1998-11-24 2001-12-26 霍利斯-伊登医药公司 17－酮甾类化合物及其衍生物、代谢产物和前体在治疗丙型肝炎病毒和其他披膜病毒中的应用
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CN100389767C (zh) * 2005-09-30 2008-05-28 天津药物研究院 一种含活性成分水飞蓟宾及其盐经注射给药的稳定的药物组合物
CN100534992C (zh) * 2005-12-26 2009-09-02 浙江海正药业股份有限公司 水飞蓟宾酯类衍生物及其制备方法和制备药物的用途
CN101244059B (zh) 2008-03-31 2010-11-17 广州佳科生物科技有限公司 一种复方水飞蓟宾注射剂及其制备方法和应用
CN101439018A (zh) 2008-11-11 2009-05-27 扬子江药业集团四川海蓉药业有限公司 一种静脉注射用水飞蓟宾类化合物乳剂及其制备方法

Also Published As

Publication number Publication date
JP5349486B2 (ja) 2013-11-20
PL2392326T3 (pl) 2018-07-31
AU2008323156B2 (en) 2012-05-31
US9248115B2 (en) 2016-02-02
ES2662700T9 (es) 2018-08-27
EP2392326B1 (de) 2018-01-24
AU2008323156A1 (en) 2009-05-22
EP2392326B9 (de) 2018-09-05
PT2219642E (pt) 2011-10-18
HK1142270A1 (en) 2010-12-03
US20130236420A1 (en) 2013-09-12
DK2219642T3 (da) 2011-12-05
ES2662700T3 (es) 2018-04-09
ES2374117T3 (es) 2012-02-13
WO2009062737A1 (en) 2009-05-22
CA2703834A1 (en) 2009-05-22
JP2011503133A (ja) 2011-01-27
CN102300570A (zh) 2011-12-28
MX2010005107A (es) 2010-05-27
US20110182858A1 (en) 2011-07-28
EP2219642B1 (de) 2011-09-21
KR101435242B1 (ko) 2014-08-29
PL2219642T3 (pl) 2012-02-29
CN102300570B (zh) 2015-01-14
EP2392326A1 (de) 2011-12-07
EP2219642A1 (de) 2010-08-25
KR20100094981A (ko) 2010-08-27
CA2703834C (en) 2014-05-20

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