EA201170695A1 - Улучшенная стабильность таблеток карбоната кальция при растворении - Google Patents

Улучшенная стабильность таблеток карбоната кальция при растворении

Info

Publication number
EA201170695A1
EA201170695A1 EA201170695A EA201170695A EA201170695A1 EA 201170695 A1 EA201170695 A1 EA 201170695A1 EA 201170695 A EA201170695 A EA 201170695A EA 201170695 A EA201170695 A EA 201170695A EA 201170695 A1 EA201170695 A1 EA 201170695A1
Authority
EA
Eurasian Patent Office
Prior art keywords
calcium carbonate
composition
molds
improved stability
astringent
Prior art date
Application number
EA201170695A
Other languages
English (en)
Other versions
EA021707B1 (ru
Inventor
Педер Мор Олсен
Поул Эгон Бертельсен
Томас Тистед
Хенрик Раун Оге
Original Assignee
Никомед Фарма Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никомед Фарма Ас filed Critical Никомед Фарма Ас
Publication of EA201170695A1 publication Critical patent/EA201170695A1/ru
Publication of EA021707B1 publication Critical patent/EA021707B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Настоящее изобретение относится к способу получения таблетки, содержащей по меньшей мере 50% мас./мас. карбоната кальция, способ включает i) обеспечение композиции частиц, содержащей a) карбонат кальция, b) вяжущий сахарный спирт, выбираемый из сорбита или изомальта или их комбинации, с) не вяжущий сахарный спирт, выбираемый из маннита, мальтита или ксилита или их комбинации; и ii) прессование указанной композиции с использованием таблетировочной машины, снабженной по меньшей мере одной парой штампов и пресс-форм, где на пару штампов и пресс-форм перед заполнением пресс-форм указанной композицией частиц распыляют композицию, включающую смазывающее средство, выбираемое из стеарата магния, стеарата кальция или стеариновой кислоты или их комбинаций.
EA201170695A 2008-11-17 2009-11-17 Способ получения таблетки, содержащей по меньшей мере 50% мас./мас. карбоната кальция, и таблетка, полученная этим способом EA021707B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08169264 2008-11-17
PCT/EP2009/008157 WO2010054845A1 (en) 2008-11-17 2009-11-17 Improved dissolution stability of calcium carbonate tablets

Publications (2)

Publication Number Publication Date
EA201170695A1 true EA201170695A1 (ru) 2011-12-30
EA021707B1 EA021707B1 (ru) 2015-08-31

Family

ID=40456895

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170695A EA021707B1 (ru) 2008-11-17 2009-11-17 Способ получения таблетки, содержащей по меньшей мере 50% мас./мас. карбоната кальция, и таблетка, полученная этим способом

Country Status (23)

Country Link
US (2) US9101565B2 (ru)
EP (1) EP2358374B1 (ru)
JP (1) JP5523467B2 (ru)
KR (1) KR101807318B1 (ru)
CN (1) CN102215847B (ru)
AU (1) AU2009315917B2 (ru)
BR (1) BRPI0921599B8 (ru)
CA (1) CA2742449C (ru)
CY (1) CY1114885T1 (ru)
DK (1) DK2358374T3 (ru)
EA (1) EA021707B1 (ru)
ES (1) ES2437851T3 (ru)
HK (1) HK1162354A1 (ru)
HR (1) HRP20131084T1 (ru)
IL (1) IL212442A (ru)
MX (1) MX2011004744A (ru)
NZ (1) NZ592528A (ru)
PL (1) PL2358374T3 (ru)
PT (1) PT2358374E (ru)
SI (1) SI2358374T1 (ru)
SM (1) SMT201400014B (ru)
WO (1) WO2010054845A1 (ru)
ZA (1) ZA201103421B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2358374T3 (da) 2008-11-17 2013-11-11 Takeda Nycomed As Forbedret opløsningsstabilitet af calciumcarbonattabletter
JP5902677B2 (ja) 2010-06-01 2016-04-13 カーギル インコーポレイテッド エリトリトール及びイソマルトの口腔内崩壊性錠剤
EP3260114A1 (en) 2016-06-21 2017-12-27 Omya International AG Method for the production of a dosage form
CN107281216B (zh) * 2017-06-16 2020-05-05 北京济美堂医药研究有限公司 含钙化合物的药物制剂
CN110575440A (zh) * 2018-06-08 2019-12-17 北京新领先医药科技发展有限公司 一种碳酸钙药物组合物的制备方法
US20220249381A1 (en) 2019-07-05 2022-08-11 TECNIMEDE - Sociedade Técnico-medicinal, SA Compressed macitentan compositions, methods and uses thereof
JP2023054786A (ja) * 2021-10-04 2023-04-14 備前化成株式会社 食品錠剤の製造方法
WO2024028300A1 (en) * 2022-08-04 2024-02-08 Symrise Ag Process for the preparation of a powder or of a pastille

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US4115553A (en) * 1973-12-10 1978-09-19 Armour Pharmaceutical Company Antacid tablets
US5204115A (en) 1990-12-12 1993-04-20 Suomen Xyrofin Oy Directly compressible xylitol and method
JP2995226B2 (ja) 1992-03-03 1999-12-27 日本ワイスレダリー株式会社 カルシウム含有チユアブル錠
US5405623A (en) 1993-09-22 1995-04-11 Wm. Wrigley Jr. Company Chewing gum compositions and methods for manufacturing same
DE4427137B4 (de) 1993-10-07 2007-08-23 Degussa Gmbh Fällungskieselsäure
US6716454B2 (en) * 1994-09-23 2004-04-06 Laboratorie Innothera, Société Anonyme Therapeutic combination of vitamin and calcium in unitary galenic tablet form, a method of obtaining it, and the use thereof
FR2724844B1 (fr) 1994-09-23 1997-01-24 Innothera Lab Sa Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
US5846506A (en) 1994-10-07 1998-12-08 Degussa Aktiengesellschaft Precipitated silicas
DE19617487A1 (de) 1996-05-02 1997-11-06 Merck Patent Gmbh Geschmacksverbesserung von Arzneimittelwirkstoffen
EA001898B1 (ru) 1996-06-14 2001-10-22 Киова Хакко Когио Ко., Лтд. Быстроразлагаемая внутрибуккально таблетка
FR2762217B1 (fr) 1997-04-16 2000-09-29 Besins Iscovesco Lab Preparation solide vitamino-calcique, son procede d'obtention et son utilisation
ITFI970184A1 (it) 1997-07-30 1999-01-30 Menarini Farma Ind Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico
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JP2001316249A (ja) 2000-05-11 2001-11-13 Lion Corp 錠剤型医薬組成物
WO2002070013A1 (fr) 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co., Ltd. Utilisation d'une poudre sechee par atomisation contenant un alcool de sucre
WO2002069934A1 (fr) 2001-03-06 2002-09-12 Kyowa Hakko Kogyo Co., Ltd. Préparations se délitant rapidement dans la bouche
NZ530511A (en) * 2001-07-16 2005-06-24 Astrazeneca Ab A tablet for treating disorders of the gastrointestinal tract comprising a proton pump inhibitor and at least one antacid that has a barrier layer to cover an enteric coating film
ES2192136B1 (es) 2002-01-04 2005-03-16 Italfarmaco, S.A. Composiciones farmaceuticas para el tratamiento o prevencion de la osteoporosis.
DE20216314U1 (de) 2002-10-22 2003-12-04 Dhw Deutsche Hydrierwerke Gmbh Rodleben Sprühgetrockneter Xylitol und aus diesem hergestellte Komprimate
CN101001611B (zh) * 2004-05-24 2013-05-22 奈科明制药有限公司 包括含钙化合物和糖醇的微粒
AU2005249175B2 (en) * 2004-06-01 2008-05-08 Takeda As Chewable, suckable and swallowable tablet containing a calcium-containing compound as an active substance
CA2601755C (en) * 2005-02-03 2014-07-29 Nycomed Pharma As Melt granulation of a composition containing a calcium-containing compound
WO2007065440A1 (en) * 2005-12-07 2007-06-14 Nycomed Pharma As Pre-compacted calcium-containing compositions
UA95093C2 (ru) * 2005-12-07 2011-07-11 Нікомед Фарма Ас Способ получения кальциесодержащего соединения
JP5306229B2 (ja) 2007-01-16 2013-10-02 コーニンクレッカ フィリップス エヌ ヴェ 混合型の指向性端末の装置発見
DK2358374T3 (da) 2008-11-17 2013-11-11 Takeda Nycomed As Forbedret opløsningsstabilitet af calciumcarbonattabletter

Also Published As

Publication number Publication date
HRP20131084T1 (hr) 2013-12-20
US20160022732A1 (en) 2016-01-28
BRPI0921599B8 (pt) 2021-05-25
SI2358374T1 (sl) 2014-01-31
AU2009315917B2 (en) 2014-11-20
CA2742449A1 (en) 2010-05-20
PL2358374T3 (pl) 2014-03-31
US9999634B2 (en) 2018-06-19
SMT201400014B (it) 2014-03-07
ES2437851T3 (es) 2014-01-14
US20110287098A1 (en) 2011-11-24
NZ592528A (en) 2013-05-31
DK2358374T3 (da) 2013-11-11
EP2358374B1 (en) 2013-09-18
IL212442A (en) 2015-10-29
US9101565B2 (en) 2015-08-11
HK1162354A1 (en) 2012-08-31
BRPI0921599A2 (pt) 2016-02-10
MX2011004744A (es) 2011-05-30
CA2742449C (en) 2018-04-24
EA021707B1 (ru) 2015-08-31
CN102215847B (zh) 2014-07-16
JP2012508706A (ja) 2012-04-12
KR101807318B1 (ko) 2018-01-10
WO2010054845A1 (en) 2010-05-20
PT2358374E (pt) 2013-12-09
KR20110086592A (ko) 2011-07-28
CN102215847A (zh) 2011-10-12
ZA201103421B (en) 2012-10-31
AU2009315917A1 (en) 2010-05-20
BRPI0921599B1 (pt) 2020-08-18
IL212442A0 (en) 2011-06-30
JP5523467B2 (ja) 2014-06-18
CY1114885T1 (el) 2016-12-14
EP2358374A1 (en) 2011-08-24

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