EA201170284A1 - Синтез производных 3,4-диарил-4,5-дигидро-(1h)-пиразол-1-карбоксамидина - Google Patents

Синтез производных 3,4-диарил-4,5-дигидро-(1h)-пиразол-1-карбоксамидина

Info

Publication number
EA201170284A1
EA201170284A1 EA201170284A EA201170284A EA201170284A1 EA 201170284 A1 EA201170284 A1 EA 201170284A1 EA 201170284 A EA201170284 A EA 201170284A EA 201170284 A EA201170284 A EA 201170284A EA 201170284 A1 EA201170284 A1 EA 201170284A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
carboxamidine
diaryl
pyrazole
dihydro
Prior art date
Application number
EA201170284A
Other languages
English (en)
Inventor
Йозефус Х. М. Ланге
Ханс Й. Сандерс
Ерун Ван Ренен
Original Assignee
Эбботт Хелткэа Продактс Б.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эбботт Хелткэа Продактс Б.В. filed Critical Эбботт Хелткэа Продактс Б.В.
Publication of EA201170284A1 publication Critical patent/EA201170284A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новому химическому пути синтеза производных 3,4-диарил-4,5-дигидро-(1Н)-пиразол-1-карбоксамидина, известных как сильные антагонисты каннабиноидного рецептора CB, и к новым промежуточным продуктам для синтеза этих соединений. Этот путь синтеза дает значительно более высокие выходы, чем те способы, о которых сообщалось, без использования коррозионных реагентов. Способ включает получение соединения формулы (I), в которой символы имеют значения, приведенные в описании.
EA201170284A 2008-08-01 2009-07-30 Синтез производных 3,4-диарил-4,5-дигидро-(1h)-пиразол-1-карбоксамидина EA201170284A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8547508P 2008-08-01 2008-08-01
EP08161619 2008-08-01
PCT/EP2009/059844 WO2010012797A2 (en) 2008-08-01 2009-07-30 Synthesis of 3,4-diaryl-4,5-dihydro-(1h)-pyrazole-1- carboxamidine derivatives

Publications (1)

Publication Number Publication Date
EA201170284A1 true EA201170284A1 (ru) 2011-06-30

Family

ID=40380031

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170284A EA201170284A1 (ru) 2008-08-01 2009-07-30 Синтез производных 3,4-диарил-4,5-дигидро-(1h)-пиразол-1-карбоксамидина

Country Status (12)

Country Link
EP (1) EP2321280A2 (ru)
JP (1) JP2011529868A (ru)
KR (1) KR20110042095A (ru)
CN (1) CN102089284A (ru)
AR (1) AR072539A1 (ru)
AU (1) AU2009275838A1 (ru)
BR (1) BRPI0916692A2 (ru)
CA (1) CA2729969A1 (ru)
EA (1) EA201170284A1 (ru)
MX (1) MX2011001211A (ru)
TW (1) TW201010981A (ru)
WO (1) WO2010012797A2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079935A1 (es) 2010-01-29 2012-02-29 Abbott Healthcare Products Bv Sintesis de derivados de pirazolin carboxamidina sustituida
US20220227714A1 (en) * 2019-05-17 2022-07-21 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services A scalable synthesis of dual-target inhibitor of cannabinoid-1 receptor and inducible nitric oxide synthase
CN111686806B (zh) * 2020-05-29 2022-09-30 黑龙江大学 一种聚[2-(3-噻吩基)乙醇]/石墨相氮化碳复合可见光催化剂的制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011438A1 (en) * 1990-01-31 1991-08-08 E.I. Du Pont De Nemours And Company Arthropodicidal pyrazolines, pyrazolidines and hydrazines
DE4005114A1 (de) * 1990-02-17 1991-08-22 Bayer Ag Substituierte pyrazolinderivate
RU2245878C2 (ru) * 2000-03-23 2005-02-10 Солвей Фармасьютикалс Б.В. Производные 4,5-дигидро-1н-пиразола, обладающие cb1-антагонистической активностью
NZ528280A (en) * 2001-09-21 2005-11-25 Solvay Pharmaceuticals B 4,5-dihydro-1H-pyrazole derivatives having potent CB1-antagonistic activity

Also Published As

Publication number Publication date
EP2321280A2 (en) 2011-05-18
AU2009275838A1 (en) 2010-02-04
TW201010981A (en) 2010-03-16
CN102089284A (zh) 2011-06-08
AR072539A1 (es) 2010-09-01
MX2011001211A (es) 2011-03-29
CA2729969A1 (en) 2010-02-04
JP2011529868A (ja) 2011-12-15
WO2010012797A3 (en) 2010-04-22
KR20110042095A (ko) 2011-04-22
WO2010012797A2 (en) 2010-02-04
BRPI0916692A2 (pt) 2016-05-17

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