EA201071178A1 - Усовершенствованные способы гашения нежелательных побочных реакций при патогенной инактивации эритроцитов - Google Patents
Усовершенствованные способы гашения нежелательных побочных реакций при патогенной инактивации эритроцитовInfo
- Publication number
- EA201071178A1 EA201071178A1 EA201071178A EA201071178A EA201071178A1 EA 201071178 A1 EA201071178 A1 EA 201071178A1 EA 201071178 A EA201071178 A EA 201071178A EA 201071178 A EA201071178 A EA 201071178A EA 201071178 A1 EA201071178 A1 EA 201071178A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- red blood
- improved methods
- subject
- adverse reactions
- undesirable adverse
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N2300/00—Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
Abstract
Настоящее изобретение предлагает усовершенствованные способы обработки композиций эритроцитов с помощью патоген-инактивирующего соединения при условиях, которые обеспечивают соответствующую инактивацию патогена при сохранении жизнеспособности клеток. Кроме того, предлагаются способы снижения степени дегидратации эритроцитов, а также подвергнутые обработке композиции эритроцитов.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4366608P | 2008-04-09 | 2008-04-09 | |
US8703408P | 2008-08-07 | 2008-08-07 | |
PCT/US2009/040032 WO2009126786A2 (en) | 2008-04-09 | 2009-04-09 | Improved quenching methods for red blood cell pathogen inactivation |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201071178A1 true EA201071178A1 (ru) | 2011-06-30 |
EA023596B1 EA023596B1 (ru) | 2016-06-30 |
Family
ID=41162599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201071178A EA023596B1 (ru) | 2008-04-09 | 2009-04-09 | Способы обработки композиции эритроцитов для инактивации патогена |
Country Status (16)
Country | Link |
---|---|
US (3) | US8900805B2 (ru) |
EP (2) | EP2285210B1 (ru) |
JP (2) | JP5916383B2 (ru) |
KR (2) | KR101742533B1 (ru) |
CN (1) | CN102046006B (ru) |
AU (1) | AU2009233807B2 (ru) |
BR (1) | BRPI0911176B8 (ru) |
CA (1) | CA2720824C (ru) |
EA (1) | EA023596B1 (ru) |
ES (1) | ES2636563T3 (ru) |
HK (1) | HK1157140A1 (ru) |
IL (1) | IL208431A (ru) |
MX (1) | MX2010011018A (ru) |
SG (2) | SG10201605663UA (ru) |
WO (1) | WO2009126786A2 (ru) |
ZA (1) | ZA201006936B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102046006B (zh) | 2008-04-09 | 2014-09-24 | 塞鲁斯公司 | 用于红细胞病原体灭活的改进猝灭方法 |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
EP3194576B1 (en) | 2014-07-23 | 2020-11-18 | Cerus Corporation | Methods for preparing platelet products |
CA2978940C (en) | 2015-03-10 | 2023-10-17 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
KR102661405B1 (ko) | 2015-04-23 | 2024-04-25 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 용기 |
BR122021024410B1 (pt) | 2015-05-18 | 2022-05-03 | Hemanext Inc | Métodos para gerenciar um banco de sangue e para prover fornecimento de produtos de sangue total armazenados para medicina de transfusão |
EP3313418B1 (en) | 2015-06-26 | 2024-03-13 | Cerus Corporation | Cryoprecipitate compositions and methods of preparation thereof |
EP3364986B1 (en) | 2015-10-23 | 2023-12-13 | Cerus Corporation | Pathogen-inactivated cryo-poor plasma and methods of use thereof |
KR20190017747A (ko) * | 2016-05-27 | 2019-02-20 | 뉴 헬스 사이언시즈 인코포레이티드 | 혐기성 혈액 저장 및 병원체 불활성화 방법 |
IT201600079328A1 (it) * | 2016-07-28 | 2018-01-28 | Altergon Sa | Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione |
US20190369087A1 (en) * | 2016-12-23 | 2019-12-05 | Cerus Corporation | Systems and methods for testing and screening using compound bound substrates |
EP3562493A1 (en) | 2016-12-31 | 2019-11-06 | Cerus Corporation | Compositions and methods for preparation of red blood cells |
US11235090B2 (en) | 2017-03-03 | 2022-02-01 | Cerus Corporation | Kits and methods for preparing pathogen-inactivated platelet compositions |
CN116571191A (zh) | 2017-12-29 | 2023-08-11 | 塞鲁斯公司 | 用于处理生物流体的系统和方法 |
WO2020023881A1 (en) * | 2018-07-27 | 2020-01-30 | Zata Pharmaceuticals, Inc. | Method for pathogens, microorganisms, and parasites inactivation |
IL281504B1 (en) | 2018-09-20 | 2024-04-01 | Cerus Corp | Methods and kits for preparing pathogen-neutralized whole blood |
CA3143732A1 (en) | 2019-06-28 | 2020-12-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2402665A (en) | 1942-11-12 | 1946-06-25 | Du Pont | Chemical process |
IT1093275B (it) | 1978-01-26 | 1985-07-19 | Snam Progetti | Composizione adatta alla purificazione del sangue e suoi impieghi |
US4337269A (en) | 1979-07-23 | 1982-06-29 | Sutton Laboratories, Inc. | Preservative compositions |
US4748120A (en) | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
US4727027A (en) | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
US5281579A (en) | 1984-03-23 | 1994-01-25 | Baxter International Inc. | Purified virus-free hemoglobin solutions and method for making same |
US4971760A (en) | 1986-03-10 | 1990-11-20 | University Of Southern California | Novel method for disinfecting red blood cells, blood platelets, blood plasma, and optical corneas and sclerae |
US4944920A (en) | 1986-08-01 | 1990-07-31 | University Of Southern California | Novel method to treat blood |
US4920143A (en) | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US5094960A (en) | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
US5055485A (en) | 1988-12-02 | 1991-10-08 | New York Blood Center, Inc. | Inactivation of viruses in cell- and protein-containing compositions using aryl diol epoxides |
US5587490A (en) | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
US5418130A (en) | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
US5232844A (en) | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
US5658722A (en) | 1990-05-15 | 1997-08-19 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using UVA1 irradiation |
US5120649A (en) | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
US5753258A (en) | 1990-10-19 | 1998-05-19 | University Of Florida | Artificial viral envelopes |
GB9218581D0 (en) | 1992-09-02 | 1992-10-14 | Pall Corp | Removal of unwanted fluids from processed blood products |
KR960703167A (ko) | 1993-06-23 | 1996-06-19 | 존 더블유. 아담슨 | 혈액내 바이러스 불활성화 시스템(system for viral inactivation of blood) |
US5591350A (en) | 1994-04-15 | 1997-01-07 | Pall Corporation | Iodine disinfection method using a gaseous iodine treated porous medium |
SE9402472L (sv) | 1994-07-13 | 1996-01-14 | Forskarpatent I Linkoeping Ab | Modifierade ytor |
US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
US5660731A (en) | 1994-11-08 | 1997-08-26 | Pall Corporation | Filter for separating photoactive agent |
US5691132A (en) | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
US5637451A (en) | 1995-03-29 | 1997-06-10 | New York Blood Center, Inc. | Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells |
US6177441B1 (en) | 1995-06-05 | 2001-01-23 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
WO1996040857A1 (en) | 1995-06-07 | 1996-12-19 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
AU722811B2 (en) | 1995-06-07 | 2000-08-10 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
US20020192632A1 (en) | 1995-06-07 | 2002-12-19 | Hei Derek J. | Method and devices for the removal of psoralens from blood products |
AU703108B2 (en) | 1995-06-07 | 1999-03-18 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants |
US6544727B1 (en) | 1995-06-07 | 2003-04-08 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
CA2198085A1 (en) | 1995-06-29 | 1997-01-23 | Hemasure, Inc. | Inactivation of pathogens using hydroxymethylamines |
US6136586A (en) | 1995-08-29 | 2000-10-24 | Vi Technologies, Inc. | Methods for the selective modification of viral nucleic acids |
US6114108A (en) | 1995-08-29 | 2000-09-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of viral nucleic acids |
DE69627202T2 (de) | 1995-11-06 | 2003-11-13 | New York Blood Ct Inc | Behandlung von roten blutzellen zur inaktivierung von virien durch verwendung von pathalocyanine und rotlicht |
WO1997018844A1 (en) | 1995-11-21 | 1997-05-29 | Pall Corporation | Inactivation method and system in biological fluids |
US20010009756A1 (en) | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
CN101676268B (zh) | 1997-01-06 | 2013-09-25 | 塞鲁斯公司 | 用于病原体灭活的脆性化合物 |
US20010018179A1 (en) | 1998-01-06 | 2001-08-30 | Derek J. Hei | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
US6093725A (en) | 1997-01-06 | 2000-07-25 | Cerus Corporation | Frangible compounds for pathogen inactivation |
US6514987B1 (en) | 1997-01-06 | 2003-02-04 | Cerus Corporation | Frangible compounds for pathogen inactivation |
US6093564A (en) | 1997-10-03 | 2000-07-25 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
WO1999034839A1 (en) | 1998-01-06 | 1999-07-15 | Cerus Corporation | Methods for quenching pathogen inactivators in biological materials |
US20030073650A1 (en) * | 1998-07-21 | 2003-04-17 | Heather Reddy | Method and apparatus for inactivation of biological contaminants using photosensitizers |
US6150109A (en) | 1999-01-25 | 2000-11-21 | V. I. TECHNOLOGIES, Inc. | Lipophilic quenching of viral inactivating agents |
US6288122B1 (en) | 1999-02-23 | 2001-09-11 | Icagen, Inc. | Gardos channel antagonists |
EP1284743A2 (en) | 2000-05-31 | 2003-02-26 | Cerus Corporation | Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity |
TW590780B (en) | 2000-06-02 | 2004-06-11 | Gambro Inc | Additive solutions containing riboflavin |
EP1365750A2 (en) * | 2000-12-21 | 2003-12-03 | Cerus Corporation | Methods for inactivation of pathogens in biological materials |
CN103961731B (zh) * | 2004-10-29 | 2017-01-18 | 塞鲁斯公司 | 用于红细胞灭活过程的改进的猝灭方法 |
CN102046006B (zh) | 2008-04-09 | 2014-09-24 | 塞鲁斯公司 | 用于红细胞病原体灭活的改进猝灭方法 |
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2009
- 2009-04-09 CN CN200980119812.5A patent/CN102046006B/zh active Active
- 2009-04-09 JP JP2011504170A patent/JP5916383B2/ja active Active
- 2009-04-09 EA EA201071178A patent/EA023596B1/ru not_active IP Right Cessation
- 2009-04-09 SG SG10201605663UA patent/SG10201605663UA/en unknown
- 2009-04-09 KR KR1020107024925A patent/KR101742533B1/ko active IP Right Grant
- 2009-04-09 EP EP09730332.5A patent/EP2285210B1/en active Active
- 2009-04-09 ES ES09730332.5T patent/ES2636563T3/es active Active
- 2009-04-09 WO PCT/US2009/040032 patent/WO2009126786A2/en active Application Filing
- 2009-04-09 SG SG2013025275A patent/SG189745A1/en unknown
- 2009-04-09 EP EP17162270.7A patent/EP3257375A1/en not_active Ceased
- 2009-04-09 KR KR1020177008174A patent/KR101896430B1/ko active IP Right Grant
- 2009-04-09 CA CA2720824A patent/CA2720824C/en active Active
- 2009-04-09 AU AU2009233807A patent/AU2009233807B2/en active Active
- 2009-04-09 MX MX2010011018A patent/MX2010011018A/es active IP Right Grant
- 2009-04-09 BR BRPI0911176A patent/BRPI0911176B8/pt active IP Right Grant
- 2009-04-09 US US12/936,763 patent/US8900805B2/en active Active
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2010
- 2010-09-29 ZA ZA2010/06936A patent/ZA201006936B/en unknown
- 2010-10-03 IL IL208431A patent/IL208431A/en active IP Right Grant
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2011
- 2011-10-27 HK HK11111595.3A patent/HK1157140A1/xx unknown
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2014
- 2014-09-16 JP JP2014187495A patent/JP2014231528A/ja active Pending
- 2014-10-31 US US14/530,415 patent/US9713627B2/en active Active
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2017
- 2017-06-20 US US15/628,510 patent/US10357516B2/en active Active
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