EA201070058A1 - Способы лечения опосредованных серотонином заболеваний и расстройств - Google Patents

Способы лечения опосредованных серотонином заболеваний и расстройств

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Publication number
EA201070058A1
EA201070058A1 EA201070058A EA201070058A EA201070058A1 EA 201070058 A1 EA201070058 A1 EA 201070058A1 EA 201070058 A EA201070058 A EA 201070058A EA 201070058 A EA201070058 A EA 201070058A EA 201070058 A1 EA201070058 A1 EA 201070058A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disorders
diseases
treatment
methods
serotonin
Prior art date
Application number
EA201070058A
Other languages
English (en)
Inventor
Филип Мэнтон Браун
Цинюнь Лю
Брайан Замбрович
Original Assignee
Лексикон Фармасьютикалз, Инк.
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Application filed by Лексикон Фармасьютикалз, Инк. filed Critical Лексикон Фармасьютикалз, Инк.
Publication of EA201070058A1 publication Critical patent/EA201070058A1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P9/12—Antihypertensives

Abstract

Раскрыты соединения, ингибирующие триптофангидроксилазу (ТРН), которые можно применять для лечения опосредованных серотонином заболеваний и расстройств, таких как, например, сердечно-сосудистые или легочные заболевания или расстройства.
EA201070058A 2007-06-26 2008-06-24 Способы лечения опосредованных серотонином заболеваний и расстройств EA201070058A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94624607P 2007-06-26 2007-06-26
PCT/US2008/067980 WO2009002964A1 (en) 2007-06-26 2008-06-24 Methods of treating serotonin-mediated diseases and disorders

Publications (1)

Publication Number Publication Date
EA201070058A1 true EA201070058A1 (ru) 2010-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070058A EA201070058A1 (ru) 2007-06-26 2008-06-24 Способы лечения опосредованных серотонином заболеваний и расстройств

Country Status (12)

Country Link
US (2) US20090005381A1 (ru)
EP (1) EP2170306A1 (ru)
JP (1) JP2010531888A (ru)
KR (1) KR20100037047A (ru)
CN (1) CN101784269A (ru)
AU (1) AU2008268494A1 (ru)
BR (1) BRPI0813212A2 (ru)
CA (1) CA2691003A1 (ru)
EA (1) EA201070058A1 (ru)
IL (1) IL202611A0 (ru)
MX (1) MX2009013990A (ru)
WO (1) WO2009002964A1 (ru)

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KR20100037047A (ko) 2010-04-08
EP2170306A1 (en) 2010-04-07
BRPI0813212A2 (pt) 2014-12-23
CA2691003A1 (en) 2008-12-31
CN101784269A (zh) 2010-07-21
JP2010531888A (ja) 2010-09-30
AU2008268494A1 (en) 2008-12-31
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