EA200970132A1 - Аналоги морфолинила и пирролидинила - Google Patents

Аналоги морфолинила и пирролидинила

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Publication number
EA200970132A1
EA200970132A1 EA200970132A EA200970132A EA200970132A1 EA 200970132 A1 EA200970132 A1 EA 200970132A1 EA 200970132 A EA200970132 A EA 200970132A EA 200970132 A EA200970132 A EA 200970132A EA 200970132 A1 EA200970132 A1 EA 200970132A1
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EA
Eurasian Patent Office
Prior art keywords
pyrrolidinyl
morphinol
analogues
urotensin
morpholinyl
Prior art date
Application number
EA200970132A
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English (en)
Other versions
EA017528B1 (ru
Inventor
Майкл Дж. Ниб
Кларк А. Сехон
Эндрю К. Вит
Криста Б. Гудман
Грен З. Ван
Original Assignee
Смитклайн Бичам Корпорейшн
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Publication date
Family has litigation
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Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA200970132A1 publication Critical patent/EA200970132A1/ru
Publication of EA017528B1 publication Critical patent/EA017528B1/ru

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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
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    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
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Abstract

Настоящее изобретение относится к морфолинилу и аналогам пирролидинила, содержащим их фармацевтическим композициям и их применению в качестве антагонистов уротензина II.
EA200970132A 2006-07-20 2007-07-20 Аналоги морфолинила и пирролидинила EA017528B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83217606P 2006-07-20 2006-07-20
US87020206P 2006-12-15 2006-12-15
PCT/US2007/073951 WO2008011551A1 (en) 2006-07-20 2007-07-20 Morpholinyl and pyrrolidinyl analogs

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002097A1 (es) * 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
WO2011061277A1 (en) 2009-11-20 2011-05-26 Glaxo Group Limited Amino aryl acetamides and their use in the treatment of malaria
EP2602248A1 (en) 2011-12-05 2013-06-12 University Of Leicester Novel pyrrole compounds
US9487510B2 (en) 2012-03-05 2016-11-08 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists
AR095883A1 (es) 2013-04-18 2015-11-18 Astellas Pharma Inc Compuestos de acetamida heterocíclica
GB201309960D0 (en) * 2013-06-04 2013-07-17 Univ Leicester Novel pyrrole derivatives
EP3013812B1 (en) 2013-06-28 2019-10-16 Nektar Therapeutics Kappa opioid agonists and uses thereof
FR3008619B1 (fr) * 2013-07-16 2018-04-20 Centre Hospitalier Universitaire De Rouen Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne
WO2015080388A1 (ko) * 2013-11-27 2015-06-04 한국화학연구원 벤조옥사지논 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 유로텐신-ii 수용체 과활성에 의한 질환의 예방 또는 치료용 약학적 조성물
KR101597205B1 (ko) * 2014-04-09 2016-02-25 한국화학연구원 벤조옥사졸론 또는 벤조싸이아졸론 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
AR105025A1 (es) 2015-06-19 2017-08-30 Astellas Pharma Inc Compuesto de imidazodiazepina
CN107652249B (zh) * 2017-09-26 2020-12-01 新昌县勤勉生物医药科技有限公司 一种1，4苯并噁嗪酮化合物的合成工艺
CN113876779B (zh) * 2021-10-29 2022-12-16 河南大学 一种utr拮抗剂gsk1562590的应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2075849T3 (es) 1988-03-16 1995-10-16 Smithkline Beecham Farma Derivados heterociclicos.
GB8824291D0 (en) 1988-10-17 1988-11-23 Zambeletti Spa L Novel use
WO1996016980A1 (en) * 1994-11-29 1996-06-06 Novartis Ag Morpholinoethylamide derivatives
US6274421B1 (en) 1998-01-09 2001-08-14 Sharp Laboratories Of America, Inc. Method of making metal gate sub-micron MOS transistor
EP1244452B1 (en) 1999-12-21 2003-09-17 SmithKline Beecham Corporation Carboxamide derivates of pyrrolidine and piperidine as urotensin-ii receptor antagonists
ATE279923T1 (de) 1999-12-21 2004-11-15 Smithkline Beecham Corp Urotensin-ii rezeptorantagonisten
US20040039017A1 (en) 2000-12-11 2004-02-26 Dashyant Dhanak Urotensin-II receptor antagonists
WO2002047456A2 (en) 2000-12-11 2002-06-20 Smithkline Beecham Corporation Urotensin-ii receptor antagonists
US6818655B2 (en) 2001-01-26 2004-11-16 Smithkline Beecham Corporation Urotensin-II receptor antagonists
IL157093A0 (en) * 2001-03-27 2004-02-08 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin ii receptor antagonists
EP1379237A2 (en) * 2001-03-29 2004-01-14 Smithkline Beecham Corporation Pyrrolidine sulfonamides
US20040138224A1 (en) * 2002-03-28 2004-07-15 Dashyant Dhanak Pyrrolidine sulfonamides
JP2004525156A (ja) 2001-03-29 2004-08-19 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
JP2004525155A (ja) 2001-03-29 2004-08-19 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
WO2002089785A1 (en) 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
US20050043536A1 (en) 2001-05-07 2005-02-24 Dashyant Dhanak Sulfonamides
US20040198979A1 (en) 2001-05-07 2004-10-07 Dashyant Dhanak Sulfonamides
AR033879A1 (es) 2001-05-07 2004-01-07 Smithkline Beecham Corp Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto
US20040152895A1 (en) 2002-05-07 2004-08-05 Dashyant Dhanak Sulfonamides
US20040142948A1 (en) 2002-05-07 2004-07-22 Dashyant Dhanak Sulfonamides
US20030100580A1 (en) 2002-06-13 2003-05-29 Dashyant Dhanak Urotensin-II receptor antagonists
TW560026B (en) * 2002-08-27 2003-11-01 Uni Tek System Inc Singulation method of the array-type work piece to be singulated having metal layer singulation street, and the array-type work piece to be singulated applying the method
WO2004043917A1 (en) 2002-11-06 2004-05-27 Smithkline Beecham Corporation Sulfonamides
WO2004043366A2 (en) 2002-11-06 2004-05-27 Smithkline Beecham Corporation Sulfonamides
AR041885A1 (es) 2002-11-06 2005-06-01 Smithkline Beecham Corp Compuesto de sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
AU2003295408A1 (en) 2002-11-06 2004-06-03 Smithkline Beecham Corporation Sulfonamides
AU2003291262A1 (en) 2002-11-06 2004-06-03 Smithkline Beecham Corporation Sulfonamides
WO2004073634A2 (en) * 2003-02-20 2004-09-02 Encysive Pharmaceuticals Inc. Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists
WO2004078114A2 (en) * 2003-02-28 2004-09-16 Encysive Pharmaceuticals Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.
TW200508221A (en) * 2003-06-13 2005-03-01 Astrazeneca Ab New azetidine compounds
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
US7404861B2 (en) * 2004-04-23 2008-07-29 Speedline Technologies, Inc. Imaging and inspection system for a dispenser and method for same
DE202004016797U1 (de) * 2004-10-30 2006-03-09 Müller, Jost, Dr. Dr. med. Vorrichtung für medizinische Infusionen
CL2007002097A1 (es) 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.

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KR20090031635A (ko) 2009-03-26
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US7749998B2 (en) 2010-07-06
AR061917A1 (es) 2008-10-01
AU2007275212B2 (en) 2012-07-05
TW200819132A (en) 2008-05-01
JP2009544623A (ja) 2009-12-17
US20090275571A1 (en) 2009-11-05
WO2008011551A1 (en) 2008-01-24
CL2007002097A1 (es) 2008-01-18
US7432258B2 (en) 2008-10-07
US20100256130A1 (en) 2010-10-07
CA2660320A1 (en) 2008-01-24
PE20080429A1 (es) 2008-06-05
CN101516378A (zh) 2009-08-26
CN101516378B (zh) 2011-06-15
EP2049118A1 (en) 2009-04-22
EA017528B1 (ru) 2013-01-30
AU2007275212A1 (en) 2008-01-24

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