EA200900247A1 - Подкожные имплантаты, высвобождающие активный компонент в течение длительного времени - Google Patents

Подкожные имплантаты, высвобождающие активный компонент в течение длительного времени

Info

Publication number
EA200900247A1
EA200900247A1 EA200900247A EA200900247A EA200900247A1 EA 200900247 A1 EA200900247 A1 EA 200900247A1 EA 200900247 A EA200900247 A EA 200900247A EA 200900247 A EA200900247 A EA 200900247A EA 200900247 A1 EA200900247 A1 EA 200900247A1
Authority
EA
Eurasian Patent Office
Prior art keywords
subcutane
implants
long time
active component
component during
Prior art date
Application number
EA200900247A
Other languages
English (en)
Other versions
EA017292B1 (ru
Inventor
Патрис Морьяк
Пьер Марьон
Original Assignee
Медиоланум Фармасьютикалз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медиоланум Фармасьютикалз Лтд. filed Critical Медиоланум Фармасьютикалз Лтд.
Publication of EA200900247A1 publication Critical patent/EA200900247A1/ru
Publication of EA017292B1 publication Critical patent/EA017292B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Предложены подкожные имплантаты, полученные экструзией, содержащие (1) микрочастицы, включающие активный ингредиент, диспергированный в PLGA матриксе, и необязательно микрочастицы (2), включающие тот же самый активный ингредиент, или (2'), включающие другой активный ингредиент, предпочтительно принадлежащие к той же самой категории, как тот, который содержится в (1); все указанные микрочастицы (1) диспергированы в матриксе из PLGA (3), имеющем температуру стеклования ниже, чем температура стеклования PLGA, содержащегося в (1).
EA200900247A 2006-08-02 2007-08-01 Подкожные имплантаты, высвобождающие активный компонент в течение длительного времени EA017292B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001545A ITMI20061545A1 (it) 2006-08-02 2006-08-02 Particelle in grado di rilasciare il principio attivo per un periodo prolungato di tempo
PCT/EP2007/057969 WO2008015238A2 (en) 2006-08-02 2007-08-01 Subcutaneous implants releasing an active principle over an extended period of time

Publications (2)

Publication Number Publication Date
EA200900247A1 true EA200900247A1 (ru) 2009-06-30
EA017292B1 EA017292B1 (ru) 2012-11-30

Family

ID=37846057

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900247A EA017292B1 (ru) 2006-08-02 2007-08-01 Подкожные имплантаты, высвобождающие активный компонент в течение длительного времени

Country Status (18)

Country Link
US (1) US20100003298A1 (ru)
EP (1) EP2054037B1 (ru)
JP (1) JP2009545564A (ru)
KR (1) KR20090037946A (ru)
CN (1) CN101553212A (ru)
AT (1) ATE451913T1 (ru)
AU (1) AU2007280397A1 (ru)
BR (1) BRPI0714515A2 (ru)
CA (1) CA2659441A1 (ru)
DE (1) DE602007003854D1 (ru)
EA (1) EA017292B1 (ru)
ES (1) ES2337419T3 (ru)
HK (1) HK1129835A1 (ru)
IT (1) ITMI20061545A1 (ru)
MX (1) MX2009001232A (ru)
PL (1) PL2054037T3 (ru)
PT (1) PT2054037E (ru)
WO (1) WO2008015238A2 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2717459A1 (en) * 2008-03-20 2009-09-24 N.V. Organon Preparation of a pharmaceutical composition for increasing bone mineral density

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1311686C (en) * 1986-06-25 1992-12-22 John Weldon Shell Controlled release bioerodible drug delivery system
US5490962A (en) * 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
KR20060027353A (ko) * 2003-06-26 2006-03-27 메디올라늄 파마슈티컬즈 리미티드 활성 성분의 초기 방출이 제한되고 후속의 연장된 방출이선형적으로 변화하는 피하 삽입물
US20050266067A1 (en) * 2004-03-02 2005-12-01 Shiladitya Sengupta Nanocell drug delivery system

Also Published As

Publication number Publication date
EP2054037B1 (en) 2009-12-16
WO2008015238A3 (en) 2008-03-20
US20100003298A1 (en) 2010-01-07
EA017292B1 (ru) 2012-11-30
MX2009001232A (es) 2009-04-28
EP2054037A2 (en) 2009-05-06
WO2008015238A8 (en) 2008-06-05
AU2007280397A1 (en) 2008-02-07
ITMI20061545A1 (it) 2008-02-03
WO2008015238A2 (en) 2008-02-07
HK1129835A1 (en) 2009-12-11
CN101553212A (zh) 2009-10-07
ATE451913T1 (de) 2010-01-15
PT2054037E (pt) 2010-03-24
DE602007003854D1 (de) 2010-01-28
PL2054037T3 (pl) 2010-05-31
BRPI0714515A2 (pt) 2013-04-24
CA2659441A1 (en) 2008-02-07
JP2009545564A (ja) 2009-12-24
ES2337419T3 (es) 2010-04-23
KR20090037946A (ko) 2009-04-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU