EA200801013A1 - Производные замещённых соединений, содержащих конденсированные бензольные кольца, и их применение в качестве лигандов ванилоидных рецепторов - Google Patents
Производные замещённых соединений, содержащих конденсированные бензольные кольца, и их применение в качестве лигандов ванилоидных рецепторовInfo
- Publication number
- EA200801013A1 EA200801013A1 EA200801013A EA200801013A EA200801013A1 EA 200801013 A1 EA200801013 A1 EA 200801013A1 EA 200801013 A EA200801013 A EA 200801013A EA 200801013 A EA200801013 A EA 200801013A EA 200801013 A1 EA200801013 A1 EA 200801013A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- derivatives
- ligands
- receptors
- compounds containing
- rings
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 title 1
- 102000011040 TRPV Cation Channels Human genes 0.000 abstract 2
- 108010062740 TRPV Cation Channels Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
Настоящее изобретение относится к производным замещенных соединений, содержащих конденсированные бензольные кольца, при этом указанные производные можно использовать в качестве лигандов ванилоидных рецепторов, к способу лечения заболеваний, патологических состояний и/или нарушений, модулируемых ванилоидными рецепторами, с использованием указанных соединений, а также к способам получения указанных соединений.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1269MU2005 | 2005-10-07 | ||
US73066005P | 2005-10-26 | 2005-10-26 | |
IN996MU2006 | 2006-06-26 | ||
US80720506P | 2006-07-13 | 2006-07-13 | |
PCT/IB2006/002814 WO2007042906A1 (en) | 2005-10-07 | 2006-10-09 | Substituted benzofused derivatives and their use as vanilloid receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200801013A1 true EA200801013A1 (ru) | 2008-10-30 |
Family
ID=37603267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801013A EA200801013A1 (ru) | 2005-10-07 | 2006-10-09 | Производные замещённых соединений, содержащих конденсированные бензольные кольца, и их применение в качестве лигандов ванилоидных рецепторов |
Country Status (12)
Country | Link |
---|---|
US (4) | US7842703B2 (ru) |
EP (1) | EP1931681B1 (ru) |
JP (1) | JP2009511465A (ru) |
KR (1) | KR20080064972A (ru) |
AP (1) | AP2008004432A0 (ru) |
AR (1) | AR057543A1 (ru) |
CA (1) | CA2624307C (ru) |
EA (1) | EA200801013A1 (ru) |
IL (1) | IL190587A0 (ru) |
NO (1) | NO20082125L (ru) |
TW (1) | TW200801013A (ru) |
WO (1) | WO2007042906A1 (ru) |
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KR20080064972A (ko) * | 2005-10-07 | 2008-07-10 | 그렌마크 파머수티칼스 에스. 아. | 치환된 벤조융합 유도체 및 이의 바닐로이드 수용체리간드로서의 용도 |
CA2647256A1 (en) * | 2006-04-18 | 2007-10-25 | Abbott Laboratories | Antagonists of the vanilloid receptor subtype 1 (vr1) and uses thereof |
EP2032585B1 (de) | 2006-05-24 | 2014-07-23 | Boehringer Ingelheim International GmbH | Substituierte pteridine als therapeutika |
WO2008110863A1 (en) * | 2007-03-15 | 2008-09-18 | Glenmark Pharmaceuticals S.A. | Indazole derivatives and their use as vanilloid receptor ligands |
JP5512948B2 (ja) | 2007-10-16 | 2014-06-04 | 参天製薬株式会社 | Trpv1媒介性疾患治療剤 |
AU2008344922A1 (en) * | 2007-12-18 | 2012-01-19 | Glenmark Pharmaceuticals, S.A. | Chromane derivatives as TRPV3 modulators |
WO2009081219A1 (en) * | 2007-12-20 | 2009-07-02 | Glenmark Pharmaceuticals, S.A. | Quinazoline derivatives as vanilloid receptor modulators |
GEP20125574B (en) * | 2008-01-11 | 2012-07-10 | Glenmark Pharmaceuticals Sa | Fused pyrimidine derivatives as trpv3 modulators |
WO2009096701A2 (en) | 2008-01-28 | 2009-08-06 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
WO2009095726A1 (en) * | 2008-01-29 | 2009-08-06 | Glenmark Pharmaceuticals, S.A. | Acrylamide derivatives as vanilloid receptor 1 modulators |
JP2011529855A (ja) | 2008-06-17 | 2011-12-15 | グレンマーク ファーマシューティカルズ, エセ.アー. | Trpv3モジュレーターとしてのクロマン誘導体 |
US8691855B2 (en) | 2008-07-02 | 2014-04-08 | Amorepacific Corporation | Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same |
WO2010023512A1 (en) * | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
MX2011004081A (es) * | 2008-10-17 | 2011-05-31 | Abbott Lab | Antagonistas trpv1. |
WO2010045402A1 (en) | 2008-10-17 | 2010-04-22 | Abbott Laboratories | Trpv1 antagonists |
US8318928B2 (en) | 2008-12-15 | 2012-11-27 | Glenmark Pharmaceuticals, S.A. | Fused imidazole carboxamides as TRPV3 modulators |
NZ595775A (en) | 2008-12-26 | 2013-07-26 | Glenmark Pharmaceuticals Sa | Fused imidazole derivatives as trpv3 antagonist |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体 |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
WO2012049555A1 (en) | 2010-10-13 | 2012-04-19 | Lupin Limited | Spirocyclic compounds as voltage-gated sodium channel modulators |
ES2673301T3 (es) * | 2010-11-03 | 2018-06-21 | University Of Hawaii | Métodos y composiciones para la prevención y el tratamiento de la hipertrofia cardíaca |
US8802711B2 (en) | 2011-03-25 | 2014-08-12 | Abbvie Inc. | TRPV1 antagonists |
US8969325B2 (en) | 2011-12-19 | 2015-03-03 | Abbvie Inc. | TRPV1 antagonists |
US8859584B2 (en) | 2011-12-19 | 2014-10-14 | Abbvie, Inc. | TRPV1 antagonists |
US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
WO2014203217A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
US9790231B2 (en) | 2013-06-24 | 2017-10-17 | Lupin Limited | Chromane and chromene derivatives and their use as CRAC modulators |
GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
JP6946412B2 (ja) | 2016-07-18 | 2021-10-06 | ヤンセン ファーマシューティカ エヌ.ベー. | タウpet画像化リガンド |
RU2755206C1 (ru) | 2020-05-20 | 2021-09-14 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б. Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Средство пролонгированного анальгетического действия и лекарственный препарат на его основе |
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-
2006
- 2006-10-09 KR KR1020087011019A patent/KR20080064972A/ko not_active Application Discontinuation
- 2006-10-09 EP EP06808980A patent/EP1931681B1/en active Active
- 2006-10-09 JP JP2008534106A patent/JP2009511465A/ja active Pending
- 2006-10-09 EA EA200801013A patent/EA200801013A1/ru unknown
- 2006-10-09 AR ARP060104442A patent/AR057543A1/es unknown
- 2006-10-09 US US12/067,879 patent/US7842703B2/en not_active Expired - Fee Related
- 2006-10-09 CA CA2624307A patent/CA2624307C/en not_active Expired - Fee Related
- 2006-10-09 AP AP2008004432A patent/AP2008004432A0/xx unknown
- 2006-10-09 WO PCT/IB2006/002814 patent/WO2007042906A1/en active Application Filing
- 2006-10-11 TW TW095137319A patent/TW200801013A/zh unknown
-
2008
- 2008-04-02 IL IL190587A patent/IL190587A0/en unknown
- 2008-05-06 NO NO20082125A patent/NO20082125L/no not_active Application Discontinuation
-
2010
- 2010-07-21 US US12/840,417 patent/US20110021549A1/en not_active Abandoned
-
2011
- 2011-07-01 US US13/174,993 patent/US20120041011A1/en not_active Abandoned
-
2012
- 2012-07-10 US US13/545,426 patent/US20120277259A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200801013A (en) | 2008-01-01 |
US20120277259A1 (en) | 2012-11-01 |
US20120041011A1 (en) | 2012-02-16 |
IL190587A0 (en) | 2008-11-03 |
JP2009511465A (ja) | 2009-03-19 |
CA2624307A1 (en) | 2007-04-19 |
AU2006300871A1 (en) | 2007-04-19 |
CA2624307C (en) | 2014-04-29 |
US20110021549A1 (en) | 2011-01-27 |
KR20080064972A (ko) | 2008-07-10 |
NO20082125L (no) | 2008-07-07 |
EP1931681A1 (en) | 2008-06-18 |
AR057543A1 (es) | 2007-12-05 |
EP1931681B1 (en) | 2012-11-14 |
US20080269253A1 (en) | 2008-10-30 |
WO2007042906A1 (en) | 2007-04-19 |
AP2008004432A0 (en) | 2008-04-30 |
US7842703B2 (en) | 2010-11-30 |
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