EA200800010A1 - Промежуточные соединения, используемые в синтезе алкилхинолиновых и алкилхиназолиновых модуляторов киназ, и соответствующие способы синтеза - Google Patents

Промежуточные соединения, используемые в синтезе алкилхинолиновых и алкилхиназолиновых модуляторов киназ, и соответствующие способы синтеза

Info

Publication number
EA200800010A1
EA200800010A1 EA200800010A EA200800010A EA200800010A1 EA 200800010 A1 EA200800010 A1 EA 200800010A1 EA 200800010 A EA200800010 A EA 200800010A EA 200800010 A EA200800010 A EA 200800010A EA 200800010 A1 EA200800010 A1 EA 200800010A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
kinaz
alkylkhynolinum
alkylkhinazolin
modulators
Prior art date
Application number
EA200800010A
Other languages
English (en)
Inventor
Нанд Баиндур
Майкл Дэвид Гаул
Кевин Дуглас Кройттер
Гочжан Сюй
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200800010A1 publication Critical patent/EA200800010A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к алкилхинолинам и алкилхиназолинам формулы С, где R, R, Rи Х имеют значения, указанные в данном описании, применению таких соединений в синтезе ингибиторов протеинтирозинкиназ, в частности ингибиторов FLT3 и/или c-kit и/или TrkB.
EA200800010A 2005-06-10 2006-06-07 Промежуточные соединения, используемые в синтезе алкилхинолиновых и алкилхиназолиновых модуляторов киназ, и соответствующие способы синтеза EA200800010A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68938405P 2005-06-10 2005-06-10
US73091905P 2005-10-27 2005-10-27
US78955106P 2006-04-05 2006-04-05
PCT/US2006/022171 WO2006135646A1 (en) 2005-06-10 2006-06-07 Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

Publications (1)

Publication Number Publication Date
EA200800010A1 true EA200800010A1 (ru) 2008-06-30

Family

ID=37038264

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800010A EA200800010A1 (ru) 2005-06-10 2006-06-07 Промежуточные соединения, используемые в синтезе алкилхинолиновых и алкилхиназолиновых модуляторов киназ, и соответствующие способы синтеза

Country Status (20)

Country Link
US (1) US7825244B2 (ru)
EP (1) EP1891040A1 (ru)
JP (1) JP2008545787A (ru)
KR (1) KR20080033234A (ru)
AR (1) AR054387A1 (ru)
AU (1) AU2006258056A1 (ru)
BR (1) BRPI0612543A2 (ru)
CA (1) CA2611219A1 (ru)
CR (1) CR9651A (ru)
EA (1) EA200800010A1 (ru)
EC (1) ECSP077993A (ru)
GT (1) GT200600250A (ru)
IL (1) IL187688A0 (ru)
MX (1) MX2007015739A (ru)
NI (1) NI200700312A (ru)
NO (1) NO20080160L (ru)
PA (1) PA8679201A1 (ru)
TW (1) TW200718694A (ru)
UY (1) UY29589A1 (ru)
WO (1) WO2006135646A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2641106C2 (ru) * 2013-10-16 2018-01-16 Фуджифилм Корпорэйшн Соль азотсодержащего гетероциклического соединения или ее кристаллическая форма, фармацевтическая композиция и ингибитор flt3

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US7825244B2 (en) 2005-06-10 2010-11-02 Janssen Pharmaceutica Nv Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
US8071768B2 (en) 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
US8880138B2 (en) * 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2641106C2 (ru) * 2013-10-16 2018-01-16 Фуджифилм Корпорэйшн Соль азотсодержащего гетероциклического соединения или ее кристаллическая форма, фармацевтическая композиция и ингибитор flt3

Also Published As

Publication number Publication date
MX2007015739A (es) 2008-04-29
NO20080160L (no) 2008-01-09
GT200600250A (es) 2007-03-14
PA8679201A1 (es) 2007-01-17
ECSP077993A (es) 2008-01-23
UY29589A1 (es) 2006-10-02
WO2006135646A1 (en) 2006-12-21
KR20080033234A (ko) 2008-04-16
US20070021436A1 (en) 2007-01-25
BRPI0612543A2 (pt) 2010-11-23
JP2008545787A (ja) 2008-12-18
CA2611219A1 (en) 2006-12-21
NI200700312A (es) 2009-02-19
EP1891040A1 (en) 2008-02-27
TW200718694A (en) 2007-05-16
AR054387A1 (es) 2007-06-20
IL187688A0 (en) 2008-08-07
CR9651A (es) 2008-09-09
AU2006258056A1 (en) 2006-12-21
US7825244B2 (en) 2010-11-02

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