UY29589A1 - Intermediarios útiles en la síntesis de moduladores de alquilquinolina y alquilquinazolina quinasa, y métodos de síntesis relacionados - Google Patents
Intermediarios útiles en la síntesis de moduladores de alquilquinolina y alquilquinazolina quinasa, y métodos de síntesis relacionadosInfo
- Publication number
- UY29589A1 UY29589A1 UY29589A UY29589A UY29589A1 UY 29589 A1 UY29589 A1 UY 29589A1 UY 29589 A UY29589 A UY 29589A UY 29589 A UY29589 A UY 29589A UY 29589 A1 UY29589 A1 UY 29589A1
- Authority
- UY
- Uruguay
- Prior art keywords
- synthesis
- alquilquinoline
- alquilquinazolina
- quinasa
- modulators
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención está dirigida a compuestos alquilquinolina y alquilquinazolina de Fórmula C: en la cual R1, R2, Rgg, y X son tal como se han definido aquí, al uso de dichos compuestos en la síntesis de los inhibidores de la proteína tirosinquinasa, particularmente los inhibidores de FLT3 y/o c-kit y/o TrkB.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68938405P | 2005-06-10 | 2005-06-10 | |
US73091905P | 2005-10-27 | 2005-10-27 | |
US78955106P | 2006-04-05 | 2006-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29589A1 true UY29589A1 (es) | 2006-10-02 |
Family
ID=37038264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29589A UY29589A1 (es) | 2005-06-10 | 2006-06-08 | Intermediarios útiles en la síntesis de moduladores de alquilquinolina y alquilquinazolina quinasa, y métodos de síntesis relacionados |
Country Status (20)
Country | Link |
---|---|
US (1) | US7825244B2 (es) |
EP (1) | EP1891040A1 (es) |
JP (1) | JP2008545787A (es) |
KR (1) | KR20080033234A (es) |
AR (1) | AR054387A1 (es) |
AU (1) | AU2006258056A1 (es) |
BR (1) | BRPI0612543A2 (es) |
CA (1) | CA2611219A1 (es) |
CR (1) | CR9651A (es) |
EA (1) | EA200800010A1 (es) |
EC (1) | ECSP077993A (es) |
GT (1) | GT200600250A (es) |
IL (1) | IL187688A0 (es) |
MX (1) | MX2007015739A (es) |
NI (1) | NI200700312A (es) |
NO (1) | NO20080160L (es) |
PA (1) | PA8679201A1 (es) |
TW (1) | TW200718694A (es) |
UY (1) | UY29589A1 (es) |
WO (1) | WO2006135646A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
US8880138B2 (en) * | 2005-09-30 | 2014-11-04 | Abbott Diabetes Care Inc. | Device for channeling fluid and methods of use |
ES2738573T3 (es) * | 2013-10-16 | 2020-01-23 | Fujifilm Corp | Sal de compuesto heterocíclico que contiene nitrógeno o cristal del mismo, composición farmacéutica e inhibidor de FLT3 |
US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
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US3517005A (en) | 1967-10-26 | 1970-06-23 | Pfizer & Co C | Certain 2- and 4-substituted quinazolines |
GB1460389A (en) | 1974-07-25 | 1977-01-06 | Pfizer Ltd | 4-substituted quinazoline cardiac stimulants |
JPS5976082A (ja) | 1982-10-23 | 1984-04-28 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
GB8320958D0 (en) | 1983-08-03 | 1983-09-07 | Pfizer Ltd | Quinazoline cardiac stimulants |
US5300515A (en) | 1991-01-31 | 1994-04-05 | Kyorin Pharmaceutical Co., Ltd. | Carbamic acid derivatives and method for preparing the same |
PT627940E (pt) | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
US5474765A (en) | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
GB2295387A (en) | 1994-11-23 | 1996-05-29 | Glaxo Inc | Quinazoline antagonists of alpha 1c adrenergic receptors |
CA2216943C (en) | 1995-04-19 | 2003-06-17 | Schneider (Usa) Inc. | Drug release coated stent |
WO1997028118A1 (en) | 1996-02-05 | 1997-08-07 | Hoechst Celanese Corporation | Process for preparing anthranilic acids |
US5948786A (en) | 1996-04-12 | 1999-09-07 | Sumitomo Pharmaceuticals Company, Limited | Piperidinylpyrimidine derivatives |
JP2001511764A (ja) | 1996-04-12 | 2001-08-14 | 住友製薬株式会社 | ピペリジニルピリミジン誘導体 |
CN1169795C (zh) | 1996-10-01 | 2004-10-06 | 协和发酵工业株式会社 | 环胺取代的含氮杂环化合物及其组合物 |
US5866562A (en) | 1996-10-25 | 1999-02-02 | Bayer Aktiengesellschaft | Ring-bridged bis-quinolines |
JP2002508366A (ja) | 1997-12-12 | 2002-03-19 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | キノリンピペラジンおよびキノリンピペリジン誘導体、それらの製造方法、ならびに複合的5−ht1a、5−ht1bおよび5−ht1d受容体アンタゴニストとしてのそれらの用途 |
DE19756388A1 (de) | 1997-12-18 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Substituierte 2-Aryl-4-amino-chinazoline |
GB9819382D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds I |
NZ514918A (en) | 1999-04-28 | 2003-11-28 | Univ Texas | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
SV2002000205A (es) | 1999-11-01 | 2002-06-07 | Lilly Co Eli | Compuestos farmaceuticos ref. x-01095 |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
EP1309567A2 (en) | 2000-08-18 | 2003-05-14 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic compounds |
WO2002016362A2 (en) | 2000-08-18 | 2002-02-28 | Cor Therapeutics, Inc. | Nitrogenous heterocyclic compounds |
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ES2249384T3 (es) | 2000-12-12 | 2006-04-01 | Neurogen Corporation | Espiro(isobenzofuran-1,4'-piperadin)-3-onas y 3h-espirobenzofuran-1,4-piperidinas. |
DE10109866A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
ATE402164T1 (de) | 2001-04-26 | 2008-08-15 | Eisai R&D Man Co Ltd | Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon |
AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
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EP1566379A4 (en) | 2002-10-29 | 2005-11-09 | Kirin Brewery | QUINOLINE AND QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FLT3 AND MEDICAL COMPOSITIONS CONTAINING SAME |
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CL2003002353A1 (es) | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
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TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
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SI1678166T1 (sl) | 2003-10-14 | 2009-10-31 | Univ Arizona State | Inhibitorji proteinske kinaze |
CN102786482A (zh) | 2003-11-21 | 2012-11-21 | 阿雷生物药品公司 | Akt蛋白激酶抑制剂 |
US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
-
2006
- 2006-06-06 US US11/422,352 patent/US7825244B2/en active Active
- 2006-06-07 EA EA200800010A patent/EA200800010A1/ru unknown
- 2006-06-07 KR KR1020087000200A patent/KR20080033234A/ko not_active Application Discontinuation
- 2006-06-07 BR BRPI0612543-3A patent/BRPI0612543A2/pt not_active IP Right Cessation
- 2006-06-07 MX MX2007015739A patent/MX2007015739A/es unknown
- 2006-06-07 EP EP06760725A patent/EP1891040A1/en not_active Withdrawn
- 2006-06-07 WO PCT/US2006/022171 patent/WO2006135646A1/en active Application Filing
- 2006-06-07 AU AU2006258056A patent/AU2006258056A1/en not_active Abandoned
- 2006-06-07 CA CA002611219A patent/CA2611219A1/en not_active Abandoned
- 2006-06-07 JP JP2008515888A patent/JP2008545787A/ja not_active Withdrawn
- 2006-06-08 GT GT200600250A patent/GT200600250A/es unknown
- 2006-06-08 UY UY29589A patent/UY29589A1/es unknown
- 2006-06-08 PA PA20068679201A patent/PA8679201A1/es unknown
- 2006-06-09 TW TW095120478A patent/TW200718694A/zh unknown
- 2006-06-09 AR ARP060102423A patent/AR054387A1/es not_active Application Discontinuation
-
2007
- 2007-11-27 IL IL187688A patent/IL187688A0/en unknown
- 2007-11-29 NI NI200700312A patent/NI200700312A/es unknown
- 2007-12-10 EC EC2007007993A patent/ECSP077993A/es unknown
-
2008
- 2008-01-09 CR CR9651A patent/CR9651A/es not_active Application Discontinuation
- 2008-01-09 NO NO20080160A patent/NO20080160L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20080033234A (ko) | 2008-04-16 |
NI200700312A (es) | 2009-02-19 |
JP2008545787A (ja) | 2008-12-18 |
TW200718694A (en) | 2007-05-16 |
CR9651A (es) | 2008-09-09 |
IL187688A0 (en) | 2008-08-07 |
BRPI0612543A2 (pt) | 2010-11-23 |
US7825244B2 (en) | 2010-11-02 |
AR054387A1 (es) | 2007-06-20 |
EP1891040A1 (en) | 2008-02-27 |
ECSP077993A (es) | 2008-01-23 |
GT200600250A (es) | 2007-03-14 |
EA200800010A1 (ru) | 2008-06-30 |
MX2007015739A (es) | 2008-04-29 |
US20070021436A1 (en) | 2007-01-25 |
NO20080160L (no) | 2008-01-09 |
AU2006258056A1 (en) | 2006-12-21 |
WO2006135646A1 (en) | 2006-12-21 |
CA2611219A1 (en) | 2006-12-21 |
PA8679201A1 (es) | 2007-01-17 |
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