NO20091374L - Pyrrolotriazin kinase inhibitorer - Google Patents

Pyrrolotriazin kinase inhibitorer

Info

Publication number
NO20091374L
NO20091374L NO20091374A NO20091374A NO20091374L NO 20091374 L NO20091374 L NO 20091374L NO 20091374 A NO20091374 A NO 20091374A NO 20091374 A NO20091374 A NO 20091374A NO 20091374 L NO20091374 L NO 20091374L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
formula
pyrrolotriazine kinase
pyrrolotriazine
compounds
Prior art date
Application number
NO20091374A
Other languages
English (en)
Inventor
Ping Chen
Brian E Fink
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20091374L publication Critical patent/NO20091374L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

(I) Oppfinnelsen tilveiebringer forbindelser med formel (I) og farmasøytisk akseptable salter derav. Forbindelsene med formel (I) hemmer tyrosinkinase-aktivitet til Trk reseptorer så som TrkA, TrkB, TrkC eller Flt-3 og gjør dem derved anvendelige som anticancer-midler.
NO20091374A 2006-11-03 2009-04-03 Pyrrolotriazin kinase inhibitorer NO20091374L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86417506P 2006-11-03 2006-11-03
PCT/US2007/083436 WO2008057994A2 (en) 2006-11-03 2007-11-02 Pyrrolotriazine kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20091374L true NO20091374L (no) 2009-07-21

Family

ID=39365255

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091374A NO20091374L (no) 2006-11-03 2009-04-03 Pyrrolotriazin kinase inhibitorer

Country Status (6)

Country Link
US (1) US7982033B2 (no)
EP (1) EP2081936B1 (no)
JP (1) JP5180967B2 (no)
CN (1) CN101535312B (no)
NO (1) NO20091374L (no)
WO (1) WO2008057994A2 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2041138T3 (pl) * 2006-07-07 2014-11-28 Bristol Myers Squibb Co Pirolotriazyny jako inhibitory kinazy
US8268998B2 (en) * 2006-11-03 2012-09-18 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
HUE035029T2 (en) 2008-05-21 2018-03-28 Ariad Pharma Inc Kinase inhibitor phosphorus derivatives
WO2010042684A1 (en) * 2008-10-08 2010-04-15 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
JP5093527B2 (ja) * 2010-02-10 2012-12-12 日本電気株式会社 複合光導波路、波長可変フィルタ、波長可変レーザ、および光集積回路
MX2013002198A (es) * 2010-08-27 2013-03-18 Merck Patent Gmbh Derivados de triazolopirazina.
CN103848833B (zh) * 2012-11-28 2016-08-31 上海希迈医药科技有限公司 吡咯并三嗪类衍生物、其制备方法及其在医药上的应用
CA2924362C (en) * 2013-09-18 2018-12-18 Beijing Hanmi Pharmaceutical Co., Ltd. Compound inhibiting activities of btk and/or jak3 kinases
CN104974163B (zh) * 2014-04-14 2017-11-07 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
FR3025717A1 (fr) * 2014-09-16 2016-03-18 Univ Lille Sciences Tech Utilisation conjointe d'un inhibiteur de trka et d'un inhibiteur de epha2 pour une utilisation dans le traitement de cancers
WO2016190847A1 (en) * 2015-05-26 2016-12-01 Calitor Sciences, Llc Substituted heteroaryl compounds and methods of use
WO2017004134A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01011832A (es) * 1999-05-21 2002-06-21 Squibb Bristol Myers Co Inhibidores de cinasas, de pirrolotriazina.
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
JP2004522713A (ja) * 2000-11-17 2004-07-29 ブリストル−マイヤーズ　スクイブ　カンパニー ｐ３８キナーゼ関連疾患の処置方法およびキナーゼインヒビターとして有用なピロロトリアジン化合物
US6670357B2 (en) 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
DK1497019T3 (en) * 2002-04-23 2015-08-03 Bristol Myers Squibb Co PYRROLO-TRIAZINANILINE COMPOSITIONS USED AS KINase INHIBITORS
US6951859B2 (en) 2002-08-02 2005-10-04 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CA2425123C (en) * 2003-01-16 2010-09-21 Decoma International Inc. Lightweight composite tailgate
US7605160B2 (en) 2006-08-09 2009-10-20 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7531539B2 (en) 2006-08-09 2009-05-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CN101687874B (zh) 2007-04-18 2013-01-30 百时美施贵宝公司 吡咯并三嗪激酶抑制剂

Also Published As

Publication number Publication date
US20100081662A1 (en) 2010-04-01
WO2008057994A2 (en) 2008-05-15
US7982033B2 (en) 2011-07-19
CN101535312B (zh) 2013-04-24
EP2081936B1 (en) 2014-04-02
JP2010509348A (ja) 2010-03-25
JP5180967B2 (ja) 2013-04-10
CN101535312A (zh) 2009-09-16
EP2081936A2 (en) 2009-07-29
WO2008057994A3 (en) 2008-09-12

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