UY29589A1 - USEFUL INTERMEDIARIES IN THE SYNTHESIS OF ALQUILQUINOLINE AND ALQUILQUINAZOLINA QUINASA MODULATORS, AND RELATED SYNTHESIS METHODS - Google Patents

USEFUL INTERMEDIARIES IN THE SYNTHESIS OF ALQUILQUINOLINE AND ALQUILQUINAZOLINA QUINASA MODULATORS, AND RELATED SYNTHESIS METHODS

Info

Publication number
UY29589A1
UY29589A1 UY29589A UY29589A UY29589A1 UY 29589 A1 UY29589 A1 UY 29589A1 UY 29589 A UY29589 A UY 29589A UY 29589 A UY29589 A UY 29589A UY 29589 A1 UY29589 A1 UY 29589A1
Authority
UY
Uruguay
Prior art keywords
synthesis
alquilquinoline
alquilquinazolina
quinasa
modulators
Prior art date
Application number
UY29589A
Other languages
Spanish (es)
Inventor
Michael David Gaul
Guozhang Xu
Nand Baindur
Kevin Douglas Kreutter
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of UY29589A1 publication Critical patent/UY29589A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención está dirigida a compuestos alquilquinolina y alquilquinazolina de Fórmula C: en la cual R1, R2, Rgg, y X son tal como se han definido aquí, al uso de dichos compuestos en la síntesis de los inhibidores de la proteína tirosinquinasa, particularmente los inhibidores de FLT3 y/o c-kit y/o TrkB.The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: in which R1, R2, Rgg, and X are as defined herein, the use of said compounds in the synthesis of protein tyrosine kinase inhibitors, particularly those FLT3 and / or c-kit and / or TrkB inhibitors.

UY29589A 2005-06-10 2006-06-08 USEFUL INTERMEDIARIES IN THE SYNTHESIS OF ALQUILQUINOLINE AND ALQUILQUINAZOLINA QUINASA MODULATORS, AND RELATED SYNTHESIS METHODS UY29589A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68938405P 2005-06-10 2005-06-10
US73091905P 2005-10-27 2005-10-27
US78955106P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
UY29589A1 true UY29589A1 (en) 2006-10-02

Family

ID=37038264

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29589A UY29589A1 (en) 2005-06-10 2006-06-08 USEFUL INTERMEDIARIES IN THE SYNTHESIS OF ALQUILQUINOLINE AND ALQUILQUINAZOLINA QUINASA MODULATORS, AND RELATED SYNTHESIS METHODS

Country Status (20)

Country Link
US (1) US7825244B2 (en)
EP (1) EP1891040A1 (en)
JP (1) JP2008545787A (en)
KR (1) KR20080033234A (en)
AR (1) AR054387A1 (en)
AU (1) AU2006258056A1 (en)
BR (1) BRPI0612543A2 (en)
CA (1) CA2611219A1 (en)
CR (1) CR9651A (en)
EA (1) EA200800010A1 (en)
EC (1) ECSP077993A (en)
GT (1) GT200600250A (en)
IL (1) IL187688A0 (en)
MX (1) MX2007015739A (en)
NI (1) NI200700312A (en)
NO (1) NO20080160L (en)
PA (1) PA8679201A1 (en)
TW (1) TW200718694A (en)
UY (1) UY29589A1 (en)
WO (1) WO2006135646A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7825244B2 (en) 2005-06-10 2010-11-02 Janssen Pharmaceutica Nv Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
US8071768B2 (en) 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
US8880138B2 (en) * 2005-09-30 2014-11-04 Abbott Diabetes Care Inc. Device for channeling fluid and methods of use
KR101744033B1 (en) * 2013-10-16 2017-06-07 후지필름 가부시키가이샤 Nitrogen-containing heterocyclic compound salt or crystal thereof, pharmaceutical composition, and flt3 inhibitor
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

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Also Published As

Publication number Publication date
AU2006258056A1 (en) 2006-12-21
TW200718694A (en) 2007-05-16
MX2007015739A (en) 2008-04-29
CA2611219A1 (en) 2006-12-21
US20070021436A1 (en) 2007-01-25
NI200700312A (en) 2009-02-19
AR054387A1 (en) 2007-06-20
PA8679201A1 (en) 2007-01-17
EP1891040A1 (en) 2008-02-27
BRPI0612543A2 (en) 2010-11-23
NO20080160L (en) 2008-01-09
WO2006135646A1 (en) 2006-12-21
IL187688A0 (en) 2008-08-07
KR20080033234A (en) 2008-04-16
EA200800010A1 (en) 2008-06-30
JP2008545787A (en) 2008-12-18
ECSP077993A (en) 2008-01-23
US7825244B2 (en) 2010-11-02
GT200600250A (en) 2007-03-14
CR9651A (en) 2008-09-09

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