EA200701998A1 - Композиции для инъекций наночастиц иммунодепрессивных соединений - Google Patents
Композиции для инъекций наночастиц иммунодепрессивных соединенийInfo
- Publication number
- EA200701998A1 EA200701998A1 EA200701998A EA200701998A EA200701998A1 EA 200701998 A1 EA200701998 A1 EA 200701998A1 EA 200701998 A EA200701998 A EA 200701998A EA 200701998 A EA200701998 A EA 200701998A EA 200701998 A1 EA200701998 A1 EA 200701998A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- nanoparticles
- injection
- tacrolimus
- sirolimus
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение направлено на композицию наночастиц иммунодепрессанта для инъекций для образования подкожного и внутримышечного депо. Изобретение также направлено на композицию наночастиц такролимуса и/или сиролимуса для инъекций, которая исключает необходимость применения в качестве солюбилизатора полиоксил 60 гидрогенизированного касторового масла (НСО-60) и/или полисорбата 80. Данное изобретение дополнительно раскрывает способ получения композиции наночастиц такролимуса и/или сиролимуса для инъекций, а также направлено на способы лечения с применением инъекционных лекарственных форм, состоящих из наночастиц, включающих такролимус, сиролимус или их комбинацию для создания подкожного и внутримышечного депо, с целью профилактики отторжения органов и лечения псориаза и других иммунных заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66269205P | 2005-03-17 | 2005-03-17 | |
PCT/US2006/009510 WO2006101972A2 (en) | 2005-03-17 | 2006-03-16 | Injectable compositions of nanoparticulate immunosuppressive compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200701998A1 true EA200701998A1 (ru) | 2008-02-28 |
Family
ID=36954386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200701998A EA200701998A1 (ru) | 2005-03-17 | 2006-03-16 | Композиции для инъекций наночастиц иммунодепрессивных соединений |
Country Status (14)
Country | Link |
---|---|
US (1) | US20060210638A1 (ru) |
EP (1) | EP1868576A2 (ru) |
JP (1) | JP2008533165A (ru) |
KR (1) | KR20070121758A (ru) |
CN (1) | CN101175481A (ru) |
AU (1) | AU2006227623B2 (ru) |
BR (1) | BRPI0606282A2 (ru) |
CA (1) | CA2601312A1 (ru) |
EA (1) | EA200701998A1 (ru) |
IL (1) | IL185952A0 (ru) |
MX (1) | MX2007011494A (ru) |
NO (1) | NO20075295L (ru) |
WO (1) | WO2006101972A2 (ru) |
ZA (1) | ZA200708458B (ru) |
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ATE531368T1 (de) * | 2003-08-29 | 2011-11-15 | Veloxis Pharmaceuticals As | Tacrolimus enthaltende zusammensetzungen mit modifizierter freisetzung |
DE602004028023D1 (de) | 2003-08-29 | 2010-08-19 | Lifecycle Pharma As | Tacrolimus enthaltende feste dispersionen |
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2006
- 2006-03-16 EP EP06738555A patent/EP1868576A2/en not_active Withdrawn
- 2006-03-16 JP JP2008502039A patent/JP2008533165A/ja active Pending
- 2006-03-16 MX MX2007011494A patent/MX2007011494A/es not_active Application Discontinuation
- 2006-03-16 US US11/376,554 patent/US20060210638A1/en not_active Abandoned
- 2006-03-16 KR KR1020077023749A patent/KR20070121758A/ko not_active Application Discontinuation
- 2006-03-16 EA EA200701998A patent/EA200701998A1/ru unknown
- 2006-03-16 BR BRPI0606282-2A patent/BRPI0606282A2/pt not_active IP Right Cessation
- 2006-03-16 CA CA002601312A patent/CA2601312A1/en not_active Abandoned
- 2006-03-16 CN CNA2006800170788A patent/CN101175481A/zh active Pending
- 2006-03-16 WO PCT/US2006/009510 patent/WO2006101972A2/en active Application Filing
- 2006-03-16 AU AU2006227623A patent/AU2006227623B2/en not_active Ceased
-
2007
- 2007-09-16 IL IL185952A patent/IL185952A0/en unknown
- 2007-10-03 ZA ZA200708458A patent/ZA200708458B/xx unknown
- 2007-10-16 NO NO20075295A patent/NO20075295L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2006101972A3 (en) | 2006-12-07 |
CN101175481A (zh) | 2008-05-07 |
MX2007011494A (es) | 2007-12-06 |
KR20070121758A (ko) | 2007-12-27 |
EP1868576A2 (en) | 2007-12-26 |
WO2006101972A2 (en) | 2006-09-28 |
AU2006227623A1 (en) | 2006-09-28 |
AU2006227623B2 (en) | 2011-10-20 |
JP2008533165A (ja) | 2008-08-21 |
NO20075295L (no) | 2007-11-29 |
BRPI0606282A2 (pt) | 2009-06-09 |
ZA200708458B (en) | 2009-05-27 |
US20060210638A1 (en) | 2006-09-21 |
CA2601312A1 (en) | 2006-09-28 |
IL185952A0 (en) | 2008-01-06 |
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