EA200701911A1 - Химерные рекомбинантные антигены toxoplasma gondii - Google Patents

Химерные рекомбинантные антигены toxoplasma gondii

Info

Publication number
EA200701911A1
EA200701911A1 EA200701911A EA200701911A EA200701911A1 EA 200701911 A1 EA200701911 A1 EA 200701911A1 EA 200701911 A EA200701911 A EA 200701911A EA 200701911 A EA200701911 A EA 200701911A EA 200701911 A1 EA200701911 A1 EA 200701911A1
Authority
EA
Eurasian Patent Office
Prior art keywords
toxoplasma gondii
chemeric
recombinant antigens
antigens
recombinant
Prior art date
Application number
EA200701911A
Other languages
English (en)
Other versions
EA013349B1 (ru
Inventor
Никола Гаргано
Элиза Бегетто
Андреа Спадони
Original Assignee
Кентон Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кентон Срл filed Critical Кентон Срл
Publication of EA200701911A1 publication Critical patent/EA200701911A1/ru
Publication of EA013349B1 publication Critical patent/EA013349B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/45—Toxoplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение, описанное здесь, относится к способу комбинирования антигенных фрагментов белков Toxoplasma gondii в форме химерных слитых продуктов и их применению в качестве диагностических и иммуногенных веществ.
EA200701911A 2005-03-08 2006-02-27 Химерные рекомбинантные антигены toxoplasma gondii EA013349B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05005065 2005-03-08
PCT/EP2006/001760 WO2006094665A1 (en) 2005-03-08 2006-02-27 Chimeric recombinant antigens of toxoplasma gondii

Publications (2)

Publication Number Publication Date
EA200701911A1 true EA200701911A1 (ru) 2008-02-28
EA013349B1 EA013349B1 (ru) 2010-04-30

Family

ID=34934134

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701911A EA013349B1 (ru) 2005-03-08 2006-02-27 Химерные рекомбинантные антигены toxoplasma gondii

Country Status (22)

Country Link
US (3) US7790187B2 (ru)
EP (1) EP1856159B1 (ru)
JP (1) JP2008535481A (ru)
KR (1) KR20080003330A (ru)
CN (1) CN101137674A (ru)
AT (1) ATE463515T1 (ru)
AU (1) AU2006222315A1 (ru)
BR (1) BRPI0608342A2 (ru)
CA (1) CA2599620A1 (ru)
CY (1) CY1110157T1 (ru)
DE (1) DE602006013428D1 (ru)
DK (1) DK1856159T3 (ru)
EA (1) EA013349B1 (ru)
ES (1) ES2342971T3 (ru)
HR (1) HRP20100370T1 (ru)
IL (1) IL184845A (ru)
MX (1) MX2007009524A (ru)
PL (1) PL1856159T3 (ru)
PT (1) PT1856159E (ru)
RS (1) RS51327B (ru)
SI (1) SI1856159T1 (ru)
WO (1) WO2006094665A1 (ru)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009003497A1 (en) * 2007-06-29 2009-01-08 Prionics Ag Diagnostic composition and method for the detection of a trichinella infection
EP2654782A4 (en) * 2010-12-23 2015-03-25 Immport Therapeutics Inc PROCESSES AND COMPOSITIONS FROM PROTEIN ANTIGEN FOR THE DIAGNOSIS AND TREATMENT OF TOXOPLASMA GONDII INFECTIONS AND TOXOPLASMOSIS
CN102288768A (zh) * 2011-09-19 2011-12-21 厦门市湖里区妇幼保健院 弓形虫IgG抗体免疫印迹试剂盒及其制备方法
CN102492696B (zh) * 2011-12-13 2014-01-29 北京英诺特生物技术有限公司 一种重组弓形虫蛋白及其应用
CN103235119B (zh) * 2013-04-11 2015-09-16 南京农业大学 一种用于弓形虫感染的诊断抗原的应用
CN103251960B (zh) * 2013-05-27 2014-08-13 山东大学 用于预防人或动物慢性弓形虫病的dna疫苗
CN104152466A (zh) * 2014-04-04 2014-11-19 中国农业科学院兰州兽医研究所 一种用于弓形虫感染预防的疫苗和制备方法及其应用
WO2016046321A1 (en) * 2014-09-25 2016-03-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for treating cancer and infectious diseases
CN105759030B (zh) * 2016-03-15 2018-01-02 中国农业大学 一种检测弓形虫抗体的胶体金试纸条
CN106153894A (zh) * 2016-08-12 2016-11-23 江苏泽成生物技术有限公司 一种测定弓形虫IgM抗体的检测试剂盒及其检测方法
CN108265070B (zh) * 2016-12-30 2022-07-26 中国农业科学院上海兽医研究所 一种特异性的检测弓形虫的方法
CN107253983A (zh) * 2017-06-28 2017-10-17 潍坊汉唐生物工程有限公司 一种检测弓形虫抗体的重组蛋白组合物及其制备方法
CN108165569A (zh) * 2017-11-10 2018-06-15 江苏省血吸虫病防治研究所 一种快速检测弓形虫的重组蛋白及其制备方法和应用
US11911464B2 (en) 2018-09-14 2024-02-27 Prommune, Inc. Anti-parasitic immunological compositions
CN109369796A (zh) * 2018-09-27 2019-02-22 华中农业大学 一种检测羊弓形虫IgG抗体的酶联免疫方法
CN110540602B (zh) * 2019-08-28 2023-02-14 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 一种弓形虫表面抗原gra1和gra7重组蛋白胶体金试纸条
CN110818787B (zh) * 2019-12-04 2023-08-04 南京医科大学 一种增加Ly6C+巨噬细胞的抗原及其应用
CN111116726A (zh) * 2020-01-14 2020-05-08 中国农业科学院北京畜牧兽医研究所 用于检测弓形虫的重组蛋白及其编码基因

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2226468A1 (en) 1973-04-18 1974-11-15 Merieux Bd Toxoplasma antigens - as agents for detecting toxoplasmosis by direct agglutination
SU533376A1 (ru) 1973-08-31 1976-10-30 Научно-исследовательский ветеринарный институт Способ получени токсоплазменного антигена
JPS5444016A (en) 1977-09-13 1979-04-07 Nippon Touketsu Kansou Kenkiyu Latex coagulation and reaction reagent for detecting toxoplasma antibody and production thereof
DE3940598A1 (de) 1989-12-08 1991-06-13 Behringwerke Ag Toxoplasma gondii-antigene, ihre herstellung und ihre verwendung
FR2518407A1 (fr) 1981-12-17 1983-06-24 Merieux Inst Nouvel antigene pour la recherche de l'immunite toxoplasmique et son procede de preparation
US6265176B1 (en) * 1985-10-29 2001-07-24 Cordis Corporation Dot immunoassay on plastic sheets
IT1196817B (it) 1986-12-03 1988-11-25 Consiglio Nazionale Ricerche Procedimento per l'ottenimento di una preparazione di antigene toxoplasmico insolubile corredo diagnostico comprendente tale preparazione e saggio diagnostico che la utilizza
FR2618680B1 (fr) 1987-07-31 1990-05-11 Pasteur Institut Antigenes d'excretion-secretion specifiques de toxoplasma gondii, leurs produits d'expression, leur procede d'obtention et leurs applications diagnostiques et prophylactiques
FR2625099B1 (fr) 1987-12-24 1991-06-14 Transgene Sa Proteines et leur procede de preparation, sequences d'adn, anticorps et leur application, poxvirus, cellules transformees ou infectees et compositions pharmaceutiques utiles dans la prevention de la toxoplasmose
US4877726A (en) * 1988-03-02 1989-10-31 Research Institute Of Palo Alto Medical Foundation Method for the detection of acute-phase toxoplasma infection
DE68926658T2 (de) 1988-03-09 1996-11-28 Univ Leland Stanford Junior Diagnostische gene zum nachweis von toxoplasmose
FR2633309B1 (fr) 1988-06-24 1992-04-24 Pasteur Institut Sequence d'adn codant pour la proteine p30 de toxoplasma gondii, produits d'expression de cette sequence, leurs procedes d'obtention et leurs applications
JPH02261382A (ja) 1989-04-03 1990-10-24 Mochida Pharmaceut Co Ltd トキソプラズマ由来新規ｄｎａ配列およびそれによってコードされる蛋白質
US5215917A (en) * 1989-11-03 1993-06-01 Research Institute Of Palo Alto Medical Foundation Nucleotide sequence encoding the Toxoplasma gondii P22 gene
US5665542A (en) * 1989-11-03 1997-09-09 Research Institute Of Palo Alto Medical Foundation Toxoplasma gondii P28 gene and methods for its use
FR2664290B1 (fr) 1990-07-05 1993-01-29 Centre Nat Rech Scient Sondes genetiques specifiques de toxoplasma gondii, et leur utilisation pour la detection in vitro de toxoplasma gondii et pour le typage des souches toxoplasmiques.
US5578453A (en) 1990-08-10 1996-11-26 The Flinders University Of South Australia Cloning and expression of toxoplasma antigens and use of recombinant antigens
GB9027728D0 (en) 1990-12-20 1991-02-13 Smithkline Beecham Biolog Novel protein
FR2692282B1 (fr) * 1992-06-15 1995-07-13 Pasteur Institut Clonage du gene codant pour la proteine gp28.5 de t. gondii; fragments peptidiques issus de ladite proteine et leurs applications.
WO1994017813A1 (en) 1993-02-08 1994-08-18 Paravax, Inc. Defective sindbis virus vectors that express toxoplasma gondii p30 antigens
FR2702491B1 (fr) 1993-03-12 1995-04-28 Pasteur Institut Clonage de gènes codant pour des antigènes d'excrétion-sécrétion P21 et P32 de toxoplasme, préparations de tels antigènes, fragments de ceux-ci et leurs applications.
US5976553A (en) * 1993-11-04 1999-11-02 The Board Of Trustees Of The Leland Stanford Junior University Transfection and genetic manipulations in obligate intracellular parasites
FR2722508B1 (fr) 1994-07-13 1996-10-04 Transgene Sa Cassette d'expression d'une proteine p30 de toxoplasma gondii
EP0710724A2 (en) 1994-10-06 1996-05-08 Akzo Nobel N.V. Toxoplasma gondii antigens
FR2729960A1 (fr) 1995-01-30 1996-08-02 Bio Merieux Polypeptides mimotopes de toxoplasma gondii et applications
EP0877809A1 (en) 1996-01-26 1998-11-18 Innogenetics N.V. TOXOPLASMA GONDII ANTIGEN Tg20
SE505631C2 (sv) 1996-08-30 1997-09-22 Scania Cv Ab Buss med tvärställt bakre drivaggregat
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
JP3831754B2 (ja) 1997-10-23 2006-10-11 青才 文江 トキソプラズマ・ゴンディ抗原、これをコードする核酸並びに該抗原に対する抗体
JP3336275B2 (ja) 1997-10-23 2002-10-21 明彦 矢野 トキソプラズマ・ゴンディ抗原、該抗原に対する抗体及び該抗原又は抗体を用いた免疫測定方法
WO1999032633A1 (en) 1997-12-19 1999-07-01 Heska Corporation Toxoplasma gondii proteins, corresponding nucleic acid molecules, and uses thereof
US5962654A (en) * 1998-01-30 1999-10-05 International Business Machines Operation Alkoxyalkoxides and use to form films
UA73718C2 (en) 1998-05-01 2005-09-15 Schering Plough Ltd Therapeutic vector expressing foreign dna, coding cat's cd80, cat's cd86, cat's cd28 or cat's ctla-4 and use thereof
US6329157B1 (en) * 1998-05-28 2001-12-11 Abbott Laboratories Antigen cocktails and uses thereof
CA2333598C (en) 1998-05-28 2009-10-13 Abbott Laboratories Toxoplasma gondii antigens, p35, and uses thereof
AU4510299A (en) 1998-06-12 2000-01-05 Smithkline Beecham Biologicals (Sa) Recombinant production of toxoplasma sag1 antigen
JP4545869B2 (ja) 2000-02-23 2010-09-15 日本ケミファ株式会社 多孔性フィルタを用いる生理活性試料物質の測定方法
FR2805466A1 (fr) 2000-02-25 2001-08-31 Virsol Utilisation de la proteine mic3 de toxoplasma gondii ou d'un de ses derives en tant qu'agent immunogene ou en tant qu'antigene de vaccination
US7176286B2 (en) 2002-03-21 2007-02-13 Kenton S.R.L. Antigen fragments for the diagnosis of Toxoplasma gondii
US7094879B2 (en) 2002-10-02 2006-08-22 Abbott Laboratories Genetically engineered P30 antigen, improved antigen cocktail, and uses thereof
CN1194991C (zh) 2003-05-09 2005-03-30 李越希 重组弓形虫融合蛋白抗原及其制备方法、应用

Also Published As

Publication number Publication date
SI1856159T1 (sl) 2010-08-31
US7867503B2 (en) 2011-01-11
MX2007009524A (es) 2008-03-04
CY1110157T1 (el) 2015-01-14
PT1856159E (pt) 2010-06-22
EP1856159A1 (en) 2007-11-21
DK1856159T3 (da) 2010-07-05
CN101137674A (zh) 2008-03-05
EA013349B1 (ru) 2010-04-30
BRPI0608342A2 (pt) 2009-12-01
IL184845A (en) 2011-06-30
AU2006222315A1 (en) 2006-09-14
US20080280307A1 (en) 2008-11-13
DE602006013428D1 (de) 2010-05-20
ES2342971T3 (es) 2010-07-20
KR20080003330A (ko) 2008-01-07
IL184845A0 (en) 2007-12-03
US20090092630A1 (en) 2009-04-09
EP1856159B1 (en) 2010-04-07
ATE463515T1 (de) 2010-04-15
HRP20100370T1 (hr) 2010-08-31
US20110027810A1 (en) 2011-02-03
JP2008535481A (ja) 2008-09-04
PL1856159T3 (pl) 2010-09-30
WO2006094665A1 (en) 2006-09-14
RS51327B (en) 2011-02-28
CA2599620A1 (en) 2006-09-14
US7790187B2 (en) 2010-09-07

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU