EA200700408A1 - Транспортный белок для доставки химических соединений в нервные клетки - Google Patents

Транспортный белок для доставки химических соединений в нервные клетки

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Publication number
EA200700408A1
EA200700408A1 EA200700408A EA200700408A EA200700408A1 EA 200700408 A1 EA200700408 A1 EA 200700408A1 EA 200700408 A EA200700408 A EA 200700408A EA 200700408 A EA200700408 A EA 200700408A EA 200700408 A1 EA200700408 A1 EA 200700408A1
Authority
EA
Eurasian Patent Office
Prior art keywords
transport protein
delivery
chemical compounds
nervous cells
protein
Prior art date
Application number
EA200700408A
Other languages
English (en)
Other versions
EA014526B1 (ru
Inventor
Андреас Руммель
Original Assignee
Токсоген Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Токсоген Гмбх filed Critical Токсоген Гмбх
Publication of EA200700408A1 publication Critical patent/EA200700408A1/ru
Publication of EA014526B1 publication Critical patent/EA014526B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к транспортному белку, который может быть получен посредством модификации тяжелой цепи нейротоксина, синтезируемого Clostridium botulinum, причем этот белок специфически связывается с нервными клетками с большим сродством, чем нативный нейротоксин. Также настоящее изобретение относится к способу получения транспортного белка, к нуклеиновой кислоте, кодирующей транспортный белок, к содержащим транспортный белок фармацевтическим и косметическим композициям и к их применению.
EA200700408A 2004-09-06 2005-09-06 Полипептид ботулинового нейротоксина в качестве транспортного белка и способы его применения EA014526B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004043009A DE102004043009A1 (de) 2004-09-06 2004-09-06 Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
PCT/EP2005/009554 WO2006027207A1 (de) 2004-09-06 2005-09-06 Transportprotein zum einbringen chemischer verbindungen in nervenzellen

Publications (2)

Publication Number Publication Date
EA200700408A1 true EA200700408A1 (ru) 2007-08-31
EA014526B1 EA014526B1 (ru) 2010-12-30

Family

ID=35583367

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700408A EA014526B1 (ru) 2004-09-06 2005-09-06 Полипептид ботулинового нейротоксина в качестве транспортного белка и способы его применения

Country Status (20)

Country Link
US (3) US8293230B2 (ru)
EP (1) EP1786832B1 (ru)
JP (2) JP5357425B2 (ru)
KR (3) KR101277280B1 (ru)
CN (1) CN101056888B (ru)
AU (1) AU2005281830B2 (ru)
BR (1) BRPI0514943A (ru)
CA (1) CA2578097C (ru)
DE (1) DE102004043009A1 (ru)
DK (1) DK1786832T3 (ru)
EA (1) EA014526B1 (ru)
ES (1) ES2390279T3 (ru)
HK (1) HK1100291A1 (ru)
IL (1) IL181481A (ru)
IN (1) IN2014DN01950A (ru)
MX (1) MX2007002737A (ru)
NO (1) NO340732B1 (ru)
UA (1) UA93359C2 (ru)
WO (1) WO2006027207A1 (ru)
ZA (1) ZA200701896B (ru)

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CA2578097C (en) 2014-05-20
HK1100291A1 (en) 2007-09-14
JP2008512089A (ja) 2008-04-24
KR20070059090A (ko) 2007-06-11
US9234011B2 (en) 2016-01-12
DK1786832T3 (da) 2012-10-22
UA93359C2 (ru) 2011-02-10
EP1786832B1 (de) 2012-07-18
ES2390279T3 (es) 2012-11-08
JP5833039B2 (ja) 2015-12-16
JP5357425B2 (ja) 2013-12-04
NO340732B1 (no) 2017-06-06
EA014526B1 (ru) 2010-12-30
JP2013139454A (ja) 2013-07-18
KR20130043251A (ko) 2013-04-29
US9422344B2 (en) 2016-08-23
NO20071825L (no) 2007-06-06
EP1786832A1 (de) 2007-05-23
DE102004043009A1 (de) 2006-03-23
BRPI0514943A (pt) 2008-07-01
CN101056888A (zh) 2007-10-17
KR20140063901A (ko) 2014-05-27
IL181481A (en) 2015-10-29
KR101277280B1 (ko) 2013-06-20
CN101056888B (zh) 2012-07-04
MX2007002737A (es) 2008-03-05
AU2005281830A1 (en) 2006-03-16
US20130116191A1 (en) 2013-05-09
US20150030584A1 (en) 2015-01-29
CA2578097A1 (en) 2006-03-16
WO2006027207A1 (de) 2006-03-16
US20070299008A1 (en) 2007-12-27
AU2005281830B2 (en) 2011-12-22
IN2014DN01950A (ru) 2015-07-10
ZA200701896B (en) 2009-05-27
US8293230B2 (en) 2012-10-23
KR101602128B1 (ko) 2016-03-10

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