EA200602175A1 - Агломерация кальцийсодержащего соединения прессованием на валках - Google Patents

Агломерация кальцийсодержащего соединения прессованием на валках

Info

Publication number
EA200602175A1
EA200602175A1 EA200602175A EA200602175A EA200602175A1 EA 200602175 A1 EA200602175 A1 EA 200602175A1 EA 200602175 A EA200602175 A EA 200602175A EA 200602175 A EA200602175 A EA 200602175A EA 200602175 A1 EA200602175 A1 EA 200602175A1
Authority
EA
Eurasian Patent Office
Prior art keywords
rolls
pressing
granular material
containing compounds
calcium
Prior art date
Application number
EA200602175A
Other languages
English (en)
Other versions
EA011746B1 (ru
Inventor
Якоб Матизен
Карстен Мартини Нильсен
Педер Мор Олсен
Пауль Эгон Бертельсен
Original Assignee
Никомед Фарма Ас
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Никомед Фарма Ас filed Critical Никомед Фарма Ас
Publication of EA200602175A1 publication Critical patent/EA200602175A1/ru
Publication of EA011746B1 publication Critical patent/EA011746B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Настоящее изобретение относится к зернистому материалу и твердой лекарственной форме, в особенности, таблеткам, включающим кальцийсодержащее соединение правильной формы, такое как соль кальция, в качестве терапевтически и/или профилактически активного вещества и фармацевтически приемлемый сахарный спирт, такой как, например, сорбит и/или изомальтоза, который имеет микроструктуру, подтвержденную СЭМ. Данное изобретение также относится к способу получения зернистого материала и твердой лекарственной формы. Способ включает агломерацию кальцийсодержащего соединения и фармацевтически приемлемого сахарного спирта прессованием на валках. Зернистый материал, полученный прессованием на валках, подходит для использования в дальнейшей переработке зернистого материала, например, в таблетки, такие как жевательные таблетки.
EA200602175A 2004-05-24 2005-05-24 Агломерация кальцийсодержащего соединения прессованием на валках EA011746B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200400813 2004-05-24
PCT/DK2005/000338 WO2005115342A1 (en) 2004-05-24 2005-05-24 Particulate comprising a calcium-containing compound and a sugar alcohol

Publications (2)

Publication Number Publication Date
EA200602175A1 true EA200602175A1 (ru) 2007-06-29
EA011746B1 EA011746B1 (ru) 2009-06-30

Family

ID=34968446

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602175A EA011746B1 (ru) 2004-05-24 2005-05-24 Агломерация кальцийсодержащего соединения прессованием на валках

Country Status (21)

Country Link
US (2) US10258576B2 (ru)
EP (1) EP1753403B1 (ru)
JP (1) JP5112860B2 (ru)
KR (1) KR100898970B1 (ru)
CN (2) CN101001611B (ru)
AU (1) AU2005247060C1 (ru)
BR (1) BRPI0511520B8 (ru)
CA (1) CA2581703C (ru)
EA (1) EA011746B1 (ru)
ES (1) ES2523148T3 (ru)
GE (1) GEP20094681B (ru)
HK (2) HK1103009A1 (ru)
IL (1) IL179411A (ru)
MX (1) MXPA06013608A (ru)
MY (1) MY144631A (ru)
NO (1) NO339208B1 (ru)
NZ (1) NZ551536A (ru)
TW (1) TWI356712B (ru)
UA (1) UA85717C2 (ru)
WO (1) WO2005115342A1 (ru)
ZA (1) ZA200609724B (ru)

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Also Published As

Publication number Publication date
US10357460B2 (en) 2019-07-23
EP1753403B1 (en) 2014-08-13
GEP20094681B (en) 2009-05-10
BRPI0511520B8 (pt) 2021-05-25
US20130028973A1 (en) 2013-01-31
BRPI0511520A (pt) 2007-12-26
TWI356712B (en) 2012-01-21
CA2581703A1 (en) 2005-12-08
CN101001611A (zh) 2007-07-18
HK1103009A1 (en) 2007-12-14
JP5112860B2 (ja) 2013-01-09
NO339208B1 (no) 2016-11-14
NZ551536A (en) 2010-10-29
JP2008500290A (ja) 2008-01-10
BRPI0511520A8 (pt) 2017-12-19
ES2523148T3 (es) 2014-11-21
AU2005247060A1 (en) 2005-12-08
KR100898970B1 (ko) 2009-05-25
TW200609003A (en) 2006-03-16
CN103550178A (zh) 2014-02-05
MY144631A (en) 2011-10-14
CN101001611B (zh) 2013-05-22
CA2581703C (en) 2015-06-30
UA85717C2 (ru) 2009-02-25
IL179411A (en) 2012-01-31
IL179411A0 (en) 2007-05-15
ZA200609724B (en) 2009-05-27
BRPI0511520B1 (pt) 2018-09-25
NO20065988L (no) 2007-01-25
AU2005247060B2 (en) 2010-09-09
EA011746B1 (ru) 2009-06-30
US20080175904A1 (en) 2008-07-24
KR20070043714A (ko) 2007-04-25
CN103550178B (zh) 2016-03-30
WO2005115342A1 (en) 2005-12-08
MXPA06013608A (es) 2007-04-26
HK1191864A1 (zh) 2014-08-08
AU2005247060C1 (en) 2011-03-31
EP1753403A1 (en) 2007-02-21
US10258576B2 (en) 2019-04-16

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