UA85717C2 - Сыпучий материал, включающий кальций-содержащее соединение и сахарный спирт - Google Patents
Сыпучий материал, включающий кальций-содержащее соединение и сахарный спирт Download PDFInfo
- Publication number
- UA85717C2 UA85717C2 UAA200613746A UAA200613746A UA85717C2 UA 85717 C2 UA85717 C2 UA 85717C2 UA A200613746 A UAA200613746 A UA A200613746A UA A200613746 A UAA200613746 A UA A200613746A UA 85717 C2 UA85717 C2 UA 85717C2
- Authority
- UA
- Ukraine
- Prior art keywords
- calcium
- sugar alcohol
- pharmaceutically acceptable
- tablets
- sorbitol
- Prior art date
Links
- 239000011575 calcium Substances 0.000 title claims abstract description 195
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 195
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 193
- 150000005846 sugar alcohols Chemical class 0.000 title claims abstract description 125
- 150000001875 compounds Chemical class 0.000 title claims abstract description 99
- 239000011236 particulate material Substances 0.000 title abstract 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 118
- 239000000600 sorbitol Substances 0.000 claims abstract description 118
- 238000000034 method Methods 0.000 claims abstract description 78
- 238000009490 roller compaction Methods 0.000 claims abstract description 59
- 239000000905 isomalt Substances 0.000 claims abstract description 42
- 235000010439 isomalt Nutrition 0.000 claims abstract description 42
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000007909 solid dosage form Substances 0.000 claims abstract description 41
- 239000013543 active substance Substances 0.000 claims abstract description 30
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 20
- -1 e.g. Chemical class 0.000 claims abstract description 19
- 238000012545 processing Methods 0.000 claims abstract description 9
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims abstract description 5
- 230000001055 chewing effect Effects 0.000 claims abstract description 4
- 229960005069 calcium Drugs 0.000 claims description 192
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 140
- 239000002245 particle Substances 0.000 claims description 119
- 235000010356 sorbitol Nutrition 0.000 claims description 117
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 112
- 239000000463 material Substances 0.000 claims description 79
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 67
- 229960003563 calcium carbonate Drugs 0.000 claims description 67
- 229940088594 vitamin Drugs 0.000 claims description 64
- 229930003231 vitamin Natural products 0.000 claims description 64
- 235000013343 vitamin Nutrition 0.000 claims description 64
- 239000011782 vitamin Substances 0.000 claims description 64
- 239000000203 mixture Substances 0.000 claims description 60
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 60
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 42
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 claims description 37
- 238000004519 manufacturing process Methods 0.000 claims description 34
- 238000003825 pressing Methods 0.000 claims description 34
- 239000013078 crystal Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 28
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 24
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 24
- 239000000811 xylitol Substances 0.000 claims description 24
- 235000010447 xylitol Nutrition 0.000 claims description 24
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 24
- 229960002675 xylitol Drugs 0.000 claims description 24
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 17
- 229930195725 Mannitol Natural products 0.000 claims description 17
- 239000002775 capsule Substances 0.000 claims description 17
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 17
- 235000010449 maltitol Nutrition 0.000 claims description 17
- 239000000845 maltitol Substances 0.000 claims description 17
- 229940035436 maltitol Drugs 0.000 claims description 17
- 239000000594 mannitol Substances 0.000 claims description 17
- 235000010355 mannitol Nutrition 0.000 claims description 17
- 229960001855 mannitol Drugs 0.000 claims description 16
- 239000002552 dosage form Substances 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 12
- 239000013590 bulk material Substances 0.000 claims description 11
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 11
- 239000001506 calcium phosphate Substances 0.000 claims description 9
- 239000008101 lactose Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 8
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 claims description 8
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 7
- 108010011485 Aspartame Proteins 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 239000000605 aspartame Substances 0.000 claims description 7
- 235000010357 aspartame Nutrition 0.000 claims description 7
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 7
- 229960003438 aspartame Drugs 0.000 claims description 7
- 239000000832 lactitol Substances 0.000 claims description 7
- 235000010448 lactitol Nutrition 0.000 claims description 7
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 7
- 229960003451 lactitol Drugs 0.000 claims description 7
- 239000003765 sweetening agent Substances 0.000 claims description 7
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 6
- 229930091371 Fructose Natural products 0.000 claims description 6
- 239000005715 Fructose Substances 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 5
- 235000011010 calcium phosphates Nutrition 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 5
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 claims description 5
- 235000010755 mineral Nutrition 0.000 claims description 5
- 239000011707 mineral Substances 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 4
- 229960004998 acesulfame potassium Drugs 0.000 claims description 4
- 239000000619 acesulfame-K Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 4
- LMVUZKNUWBMHQY-FJOGWHKWSA-L calcium (Z)-but-2-enedioate 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Ca+2].[O-]C(=O)\C=C/C([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O LMVUZKNUWBMHQY-FJOGWHKWSA-L 0.000 claims description 4
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 4
- 239000001354 calcium citrate Substances 0.000 claims description 4
- 239000004227 calcium gluconate Substances 0.000 claims description 4
- 235000013927 calcium gluconate Nutrition 0.000 claims description 4
- 229960004494 calcium gluconate Drugs 0.000 claims description 4
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 4
- OFNJDDJDXNMTHZ-UHFFFAOYSA-L calcium;2-aminoacetate Chemical compound [Ca+2].NCC([O-])=O.NCC([O-])=O OFNJDDJDXNMTHZ-UHFFFAOYSA-L 0.000 claims description 4
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 4
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 4
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 4
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 4
- CVHZOJJKTDOEJC-UHFFFAOYSA-M 1,1-dioxo-1,2-benzothiazol-3-olate Chemical compound C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-M 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 3
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 claims description 3
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 3
- 229940043202 calcium cyclamate Drugs 0.000 claims description 3
- LNMAXKMUGYXKPJ-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one Chemical compound [Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 LNMAXKMUGYXKPJ-UHFFFAOYSA-L 0.000 claims description 3
- LFVPBERIVUNMGV-UHFFFAOYSA-N fasudil hydrochloride Chemical compound Cl.C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 LFVPBERIVUNMGV-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 3
- 229960000367 inositol Drugs 0.000 claims description 3
- HEKURBKACCBNEJ-UHFFFAOYSA-M potassium;1,1-dioxo-1,2-benzothiazol-2-id-3-one Chemical compound [K+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 HEKURBKACCBNEJ-UHFFFAOYSA-M 0.000 claims description 3
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 3
- 229960001462 sodium cyclamate Drugs 0.000 claims description 3
- 230000009747 swallowing Effects 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 229930003448 Vitamin K Natural products 0.000 claims description 2
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 2
- 239000001527 calcium lactate Substances 0.000 claims description 2
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- 235000011086 calcium lactate Nutrition 0.000 claims description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
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Landscapes
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- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Abstract
Данное изобретение относится к сыпучему материалу и твердой лекарственной форме, а именно таблеткам, которые включают кальций-содержащее соединение с регулярной формой частиц, например соль кальция, как терапевтически и/или профилактически активную субстанцию, и фармацевтически приемлемый сахарный спирт, например сорбит и/или изомальт, который имеет микроструктуру, что доказано с помощью СЭМ. Изобретение также относится к способу изготовления сыпучего материала и твердой лекарственной формы. Способ включает агломерацию кальций-содержащего соединения и фармацевтически приемлемого сахарного спирта с помощью роллерного уплотнения. Сыпучий материал, полученный путем роллерного уплотнения, является пригодным для использования в последующей обработке сыпучего материала с получением, например, таблеток, таких как жевательные таблетки.
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DKPA200400813 | 2004-05-24 |
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UA85717C2 true UA85717C2 (ru) | 2009-02-25 |
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UAA200613746A UA85717C2 (ru) | 2004-05-24 | 2005-05-24 | Сыпучий материал, включающий кальций-содержащее соединение и сахарный спирт |
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EP (1) | EP1753403B1 (ru) |
JP (1) | JP5112860B2 (ru) |
KR (1) | KR100898970B1 (ru) |
CN (2) | CN103550178B (ru) |
AU (1) | AU2005247060C1 (ru) |
BR (1) | BRPI0511520B8 (ru) |
CA (1) | CA2581703C (ru) |
EA (1) | EA011746B1 (ru) |
ES (1) | ES2523148T3 (ru) |
GE (1) | GEP20094681B (ru) |
HK (2) | HK1103009A1 (ru) |
IL (1) | IL179411A (ru) |
MX (1) | MXPA06013608A (ru) |
MY (1) | MY144631A (ru) |
NO (1) | NO339208B1 (ru) |
NZ (1) | NZ551536A (ru) |
TW (1) | TWI356712B (ru) |
UA (1) | UA85717C2 (ru) |
WO (1) | WO2005115342A1 (ru) |
ZA (1) | ZA200609724B (ru) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2324957T5 (es) * | 2005-03-04 | 2012-08-21 | Nycomed Pharma As | Proceso para la producción de composiciones de calcio en un lecho fluido continuo |
UA92052C2 (ru) | 2005-12-07 | 2010-09-27 | Нікомед Фарма Ас | Предварительно уплотненные кальциесодержащие композиции |
UA95093C2 (ru) | 2005-12-07 | 2011-07-11 | Нікомед Фарма Ас | Способ получения кальциесодержащего соединения |
CA2835910C (en) * | 2007-04-25 | 2016-06-28 | Warner Chilcott Company, Llc | Improved vitamin d content uniformity in pharmaceutical dosage forms |
US9386783B2 (en) * | 2007-07-31 | 2016-07-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products and process for obtaining them |
FR2929512B1 (fr) * | 2008-04-08 | 2010-12-31 | Roquette Freres | Composition pulverulente de maltitol cristallise de grande fluidite et non mottante |
DK2358374T3 (da) * | 2008-11-17 | 2013-11-11 | Takeda Nycomed As | Forbedret opløsningsstabilitet af calciumcarbonattabletter |
WO2011020527A1 (en) * | 2009-08-18 | 2011-02-24 | Cargill, Incorporated | Process for compressing isomalt |
WO2011085442A1 (en) | 2010-01-12 | 2011-07-21 | Mars, Incorporated | Multi-component pet food and method of manufacturing solid component |
CN102228178B (zh) * | 2011-06-18 | 2013-04-17 | 赤峰多维尔生物工程有限公司 | 钙铁锌硒颗粒 |
FR2991582B1 (fr) * | 2012-06-11 | 2014-06-13 | Isp Investments Inc | Extrait de fibres de coton et composition cosmetique et leur utilisation pour proteger, nourrir et hydrater la peau |
CN103349081B (zh) * | 2013-06-14 | 2016-01-20 | 芜湖市诺康生物科技有限公司 | 一种多味钙咀嚼片及其制作工艺 |
WO2015020191A1 (ja) * | 2013-08-09 | 2015-02-12 | 日東薬品工業株式会社 | カルシウム剤 |
US9514620B2 (en) * | 2013-09-06 | 2016-12-06 | Immersion Corporation | Spatialized haptic feedback based on dynamically scaled values |
CN103845357A (zh) * | 2013-12-09 | 2014-06-11 | 浙江佐力药业股份有限公司 | 一种用于儿童补钙的维d钙咀嚼片及其制备方法 |
EP3260114A1 (en) | 2016-06-21 | 2017-12-27 | Omya International AG | Method for the production of a dosage form |
IT201700099708A1 (it) * | 2017-09-06 | 2019-03-06 | Abiogen Pharma Spa | Composizione per l’integrazione di calcio |
EP3675656B1 (en) * | 2017-10-05 | 2021-11-10 | Purac Biochem B.V. | Lactate powder and method for the preparation thereof |
CN107960663A (zh) * | 2017-11-24 | 2018-04-27 | 南通励成生物工程有限公司 | 碳酸钙营养强化剂及制备方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS536229A (en) | 1976-07-08 | 1978-01-20 | Toyota Motor Co Ltd | Fixing jig |
EP0047734A1 (en) | 1980-03-10 | 1982-03-24 | Edward Mendell Co., Inc. | Pharmaceutical vehicle composition and process of producing same |
IE52274B1 (en) | 1980-12-12 | 1987-09-02 | Stauffer Chemical Co | A process of compacting fine particles of calcium phosphate and the compacts obtained thereby |
US4684534A (en) * | 1985-02-19 | 1987-08-04 | Dynagram Corporation Of America | Quick-liquifying, chewable tablet |
CA1279574C (en) * | 1985-04-17 | 1991-01-29 | Jeffrey L. Finnan | Process for lubricating water-soluble vitamin powders |
CA1325707C (en) | 1986-10-31 | 1994-01-04 | Chihang Raymond Chu | Granular tricalcium phosphate compositions suitable for direct compression tableting |
US5536526A (en) * | 1988-01-11 | 1996-07-16 | Cultor Ltd. | Xylitol-based binding and diluting agent and a process for the production thereof |
US5296236A (en) * | 1988-09-16 | 1994-03-22 | Recordati S.A., Chemical And Pharmaceutical Company | Controlled release therapeutic system for a liquid pharmaceutical formulations |
US5348745A (en) * | 1989-05-09 | 1994-09-20 | Miles Inc. | Aqueous granulation solution and a method of tablet granulation |
DE4006734C1 (ru) * | 1990-03-03 | 1991-07-25 | Benckiser-Knapsack Gmbh, 6802 Ladenburg, De | |
US5204115A (en) | 1990-12-12 | 1993-04-20 | Suomen Xyrofin Oy | Directly compressible xylitol and method |
JP2995226B2 (ja) | 1992-03-03 | 1999-12-27 | 日本ワイスレダリー株式会社 | カルシウム含有チユアブル錠 |
US5405623A (en) | 1993-09-22 | 1995-04-11 | Wm. Wrigley Jr. Company | Chewing gum compositions and methods for manufacturing same |
DE4427137B4 (de) | 1993-10-07 | 2007-08-23 | Degussa Gmbh | Fällungskieselsäure |
FR2717387B1 (fr) * | 1994-03-17 | 1996-10-18 | Hi Pharmtech | Procédé de fabrication de comprimés à croquer à base de troxérutine, de carbonate de calcium, de phosphate de calcium, d'aspartate d'arginine, de glutamate d'arginine d'amoxicilline. |
FR2717389B1 (fr) | 1994-03-18 | 1996-06-07 | Lvmh Rech | Utilisation du ginsénoside Ro ou d'un extrait végétal en contenant pour stimuler la synthèse du collagène. |
FR2724844B1 (fr) | 1994-09-23 | 1997-01-24 | Innothera Lab Sa | Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation |
DE19617487A1 (de) | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
US5853759A (en) * | 1996-05-17 | 1998-12-29 | Merck & Co.. Inc. | Effervescent alendronate formulation |
CN1154479C (zh) | 1996-06-14 | 2004-06-23 | 协和发酵工业株式会社 | 口腔内快速崩解片剂 |
SE9603667D0 (sv) * | 1996-10-08 | 1996-10-08 | Astra Ab | Pharmaceutical compositions |
FR2762217B1 (fr) | 1997-04-16 | 2000-09-29 | Besins Iscovesco Lab | Preparation solide vitamino-calcique, son procede d'obtention et son utilisation |
US5939091A (en) * | 1997-05-20 | 1999-08-17 | Warner Lambert Company | Method for making fast-melt tablets |
ITFI970184A1 (it) | 1997-07-30 | 1999-01-30 | Menarini Farma Ind | Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico |
CA2301282A1 (en) | 1997-08-20 | 1999-02-25 | Pradeepkumar P. Sanghvi | Process for improving flow and compression of tableting compositions |
PL197989B1 (pl) * | 1997-12-19 | 2008-05-30 | Smithkline Beecham Corp | Sposób wytwarzania szybko rozpraszających się tabletek do podawania doustnego, szybko rozpraszający się preparat farmaceutyczny w postaci tabletek i szybko rozpraszająca się, farmaceutycznie dopuszczalna, tabletka do podawania doustnego |
US6147251A (en) | 1998-11-06 | 2000-11-14 | Uniroyal Chemical Company, Inc. | Process for the preparation and uses of derivatives of esters of α-methylene-β-hydroxy acids |
GB9825033D0 (en) * | 1998-11-13 | 1999-01-13 | Nycomed Pharma As | Process |
DE19927537A1 (de) | 1999-06-16 | 2000-12-21 | Merck Patent Gmbh | Sprühtrocknungsanlage und Verfahren zu ihrer Verwendung |
GB0003782D0 (en) * | 2000-02-17 | 2000-04-05 | Dumex Ltd As | Process |
DE50011442D1 (de) | 2000-02-18 | 2005-12-01 | Glatt Ingtech Gmbh | Verfahren zur Herstellung von Vollwaschmitteln und Vollwaschmittelkomponenten |
AR028064A1 (es) | 2000-05-03 | 2003-04-23 | Omnia Fertilizer Ltd | Metodo para producir granulos de nitrato de calcio |
JP2001316249A (ja) * | 2000-05-11 | 2001-11-13 | Lion Corp | 錠剤型医薬組成物 |
WO2002007957A2 (en) * | 2000-07-24 | 2002-01-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Apparatus and method for predicting the suitability of a substance for dry granulation by roller compaction using small sample sizes |
US20040121006A1 (en) | 2001-03-06 | 2004-06-24 | Shoichi Narita | Utilization of spray-dried powder containing sugar alcohol |
US20040071772A1 (en) * | 2001-03-06 | 2004-04-15 | Shoichi Narita | Preparations quickly disintegrating in oral cavity |
JP2003016785A (ja) * | 2001-06-28 | 2003-01-17 | Sharp Corp | 半導体記憶装置およびそれを用いた情報機器 |
CA2465159A1 (en) * | 2001-11-02 | 2003-05-15 | Sandoz Inc. | Process for preparing quick dissolving, high loading ribavirin compositions |
ES2192136B1 (es) | 2002-01-04 | 2005-03-16 | Italfarmaco, S.A. | Composiciones farmaceuticas para el tratamiento o prevencion de la osteoporosis. |
US6881419B2 (en) * | 2002-04-09 | 2005-04-19 | William E. Lovett | Vitamin formulation for enhancing bone strength |
DE20216314U1 (de) | 2002-10-22 | 2003-12-04 | Dhw Deutsche Hydrierwerke Gmbh Rodleben | Sprühgetrockneter Xylitol und aus diesem hergestellte Komprimate |
US20040166162A1 (en) * | 2003-01-24 | 2004-08-26 | Robert Niecestro | Novel pharmaceutical formulation containing a proton pump inhibitor and an antacid |
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2005
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- 2005-05-24 EA EA200602175A patent/EA011746B1/ru not_active IP Right Cessation
- 2005-05-24 AU AU2005247060A patent/AU2005247060C1/en active Active
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