EA200501773A1 - Детоксифицированный tnf и способ получения - Google Patents

Детоксифицированный tnf и способ получения

Info

Publication number
EA200501773A1
EA200501773A1 EA200501773A EA200501773A EA200501773A1 EA 200501773 A1 EA200501773 A1 EA 200501773A1 EA 200501773 A EA200501773 A EA 200501773A EA 200501773 A EA200501773 A EA 200501773A EA 200501773 A1 EA200501773 A1 EA 200501773A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tnfα
analogue
analog
immunogenic
provides
Prior art date
Application number
EA200501773A
Other languages
English (en)
Other versions
EA008254B1 (ru
Inventor
Томас Братт
Стеен Клюснер
Финн Нильсен
Серен Моуритсен
Бьерн Вольдборг
Original Assignee
Фармекса А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармекса А/С filed Critical Фармекса А/С
Publication of EA200501773A1 publication Critical patent/EA200501773A1/ru
Publication of EA008254B1 publication Critical patent/EA008254B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Данное изобретение обеспечивает иммуногенный аналог белка TNFα человека, где указанный аналог содержит иммуногенный мономерный полипептид TNFα или ди- или тример TNFα и где этот аналог дополнительно содержит уменьшающую или устраняющую токсичность мутацию, выбранную из группы, состоящей из Y87S, D143N или A145R, причем нумерация аминокислот устанавливается от N-концевого валина в TNFα человека. Данное изобретение обеспечивает также фрагмент нуклеиновой кислоты, кодирующий этот аналог, а также векторы и трансформированные клетки, применимые в получении этого аналога. Описаны также способы понижающей регуляции TNFα у субъекта, нуждающегося в этом.
EA200501773A 2003-05-09 2004-05-06 Детоксифицированный tnf и способ получения EA008254B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46949103P 2003-05-09 2003-05-09
DKPA200300701 2003-05-09
PCT/DK2004/000329 WO2004099244A2 (en) 2003-05-09 2004-05-06 Immunogenic human tnf alpha analogues with reduced cytotoxicity and methods of their preparation

Publications (2)

Publication Number Publication Date
EA200501773A1 true EA200501773A1 (ru) 2006-06-30
EA008254B1 EA008254B1 (ru) 2007-04-27

Family

ID=33436006

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501773A EA008254B1 (ru) 2003-05-09 2004-05-06 Детоксифицированный tnf и способ получения

Country Status (11)

Country Link
US (1) US20060222624A1 (ru)
EP (1) EP1625157A2 (ru)
JP (1) JP2007523605A (ru)
KR (1) KR20060015595A (ru)
AU (1) AU2004235875A1 (ru)
CA (1) CA2524623A1 (ru)
EA (1) EA008254B1 (ru)
MX (1) MXPA05011965A (ru)
NO (1) NO20055724L (ru)
NZ (1) NZ543976A (ru)
WO (1) WO2004099244A2 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004014983A1 (de) * 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1054937A (en) 1975-01-28 1979-05-22 Gursaran P. Talwar Antipregnancy vaccine
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4596792A (en) 1981-09-04 1986-06-24 The Regents Of The University Of California Safe vaccine for hepatitis containing polymerized serum albumin
JPS5938877A (ja) 1982-08-30 1984-03-02 Musashi Eng Kk 紙葉判別方法
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
EP0224574A4 (en) 1985-06-04 1988-04-26 Biotech Res Partners Ltd SELF-ANTIGEN VACCINES.
JPH02177896A (ja) * 1988-12-28 1990-07-10 Teijin Ltd 新規生理活性ポリペプチド
KR20050044857A (ko) 2001-11-16 2005-05-13 파멕사 에이/에스 무차별 ｔ 세포 에피토프 삽입물을 갖는 멀티머 단백질의면역원성 모방체
US20030185845A1 (en) * 2001-11-16 2003-10-02 Steen Klysner Novel immunogenic mimetics of multimer proteins

Also Published As

Publication number Publication date
AU2004235875A1 (en) 2004-11-18
NZ543976A (en) 2008-04-30
EA008254B1 (ru) 2007-04-27
KR20060015595A (ko) 2006-02-17
CA2524623A1 (en) 2004-11-18
WO2004099244A3 (en) 2004-12-29
EP1625157A2 (en) 2006-02-15
WO2004099244A2 (en) 2004-11-18
MXPA05011965A (es) 2006-02-02
NO20055724L (no) 2005-11-30
US20060222624A1 (en) 2006-10-05
JP2007523605A (ja) 2007-08-23

Similar Documents

Publication Publication Date Title
EA199900355A1 (ru) Теломераза обратная тринскриптаза
WO2000075350A3 (en) Nucleic acid sequences encoding proteins involved in fatty acid beta-oxidation and methods of use
EP1801219A3 (en) Neisserial antigenic peptides
ATE429448T1 (de) Peptidzusammensetzung als immunogen zur allergiebehandlung.
HUP0301356A2 (hu) Új, DPPIV-gyel rokon szerin proteáz gének
DE69534374D1 (de) Methoden und zubehör zur immunisierung von wirtsorganismen durch verabreichung nackter polynucleotide , welche für antigene peptide codieren
BG100771A (en) Hematopoeic protein and ways and methods for its preparation
HUP0101734A2 (hu) Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk
ATE397061T1 (de) Verfahren zur herstellung von proteinen
NO960309L (no) Agonister og antagonister for humaninterleukin-10
WO2002008277A3 (en) Nucleic acids, vectors, host cells, polypeptides, and uses thereof
ATE477272T1 (de) Verwendung von stefin a als gerüstprotein
ATE534909T1 (de) Verfahren zur proteomischen profilierung mithilfe nichtnatürlicher aminosäuren
EA200600738A1 (ru) Способ
DE602004027362D1 (de) Zusammensetzungen und verfahren mit dem respiratory syncytial virus untergruppe b stamm 9320
EA200501773A1 (ru) Детоксифицированный tnf и способ получения
EP1829552A3 (en) Chlamydia PMP proteins, gene sequences and uses thereof
WO2002004630A3 (en) Methods for recombinatorial nucleic acid synthesis
WO2003106650A3 (en) NUCLEIC ACIDS ENCODING CHD5, POLYPEPTIDES, ANTIBODIES AND METHODS OF USE THEREOF
DE60134408D1 (de) Für akzessorische hiv proteine kodierende dna impfstoffe
EP2261332A3 (en) Libraries of recombinant chimeric proteins
WO2002012475A3 (en) C1q-related factor, homologous polypeptides and therapeutic uses thereof
WO2002070667A3 (en) High level insect expression of rage proteins
DK0811068T3 (da) Humane DNase I varianter
ATE439368T1 (de) Schnellreifende fluoreszierende proteine und verfahren zu deren anwendung

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM