NO20055724L - Immunogene humane TNF alfa analoger med redusert cytotoksisiter og fremgangsmater for deres fremstilling - Google Patents
Immunogene humane TNF alfa analoger med redusert cytotoksisiter og fremgangsmater for deres fremstillingInfo
- Publication number
- NO20055724L NO20055724L NO20055724A NO20055724A NO20055724L NO 20055724 L NO20055724 L NO 20055724L NO 20055724 A NO20055724 A NO 20055724A NO 20055724 A NO20055724 A NO 20055724A NO 20055724 L NO20055724 L NO 20055724L
- Authority
- NO
- Norway
- Prior art keywords
- tnfα
- analog
- preparation
- methods
- tnf alpha
- Prior art date
Links
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 title abstract 3
- 102000057041 human TNF Human genes 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003013 cytotoxicity Effects 0.000 title 1
- 231100000135 cytotoxicity Toxicity 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000002222 downregulating effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102220033889 rs62643621 Human genes 0.000 abstract 1
- 239000013638 trimer Substances 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Foreliggende oppfinnelse fremskaffer en immonogenisk analog av human TNFa protein, hvor nevnte analog omfatter et immunogenisert monomert TNFa polypeptid eller TNFa di- eller trimer, og hvor analogen ytterhgere omfatter toksisitetsreduserende eller -fjernende mutasjoner valgt blant gruppen bestående av Y87S, D 143N eller A145R, hvor aminosyrenummereringen er fra den N-terminale valin i humant TNFa. Oppfinnelsen fremskaffer også nukleinsyrefragment som koder for analogen så vel som vektorer og transformerte celler som er nyttige i fremstillingen av analogen. Det blir også diskutert fremgangsmåter for nedregulering av TNFa i et individ med behov for dette.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46949103P | 2003-05-09 | 2003-05-09 | |
DKPA200300701 | 2003-05-09 | ||
PCT/DK2004/000329 WO2004099244A2 (en) | 2003-05-09 | 2004-05-06 | Immunogenic human tnf alpha analogues with reduced cytotoxicity and methods of their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20055724L true NO20055724L (no) | 2005-11-30 |
Family
ID=33436006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20055724A NO20055724L (no) | 2003-05-09 | 2005-11-30 | Immunogene humane TNF alfa analoger med redusert cytotoksisiter og fremgangsmater for deres fremstilling |
Country Status (11)
Country | Link |
---|---|
US (1) | US20060222624A1 (no) |
EP (1) | EP1625157A2 (no) |
JP (1) | JP2007523605A (no) |
KR (1) | KR20060015595A (no) |
AU (1) | AU2004235875A1 (no) |
CA (1) | CA2524623A1 (no) |
EA (1) | EA008254B1 (no) |
MX (1) | MXPA05011965A (no) |
NO (1) | NO20055724L (no) |
NZ (1) | NZ543976A (no) |
WO (1) | WO2004099244A2 (no) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004014983A1 (de) * | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung |
GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1054937A (en) | 1975-01-28 | 1979-05-22 | Gursaran P. Talwar | Antipregnancy vaccine |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4596792A (en) | 1981-09-04 | 1986-06-24 | The Regents Of The University Of California | Safe vaccine for hepatitis containing polymerized serum albumin |
JPS5938877A (ja) | 1982-08-30 | 1984-03-02 | Musashi Eng Kk | 紙葉判別方法 |
US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
US4599230A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
US4599231A (en) | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
US4608251A (en) | 1984-11-09 | 1986-08-26 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
US4601903A (en) | 1985-05-01 | 1986-07-22 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease |
AU5993186A (en) | 1985-06-04 | 1987-01-07 | Biotechnology Research Partners Limited | Autoantigen vaccines |
JPH02177896A (ja) * | 1988-12-28 | 1990-07-10 | Teijin Ltd | 新規生理活性ポリペプチド |
CN1615316A (zh) * | 2001-11-16 | 2005-05-11 | 法麦克萨有限公司 | 多聚体蛋白质的新免疫原性模拟物 |
US20030185845A1 (en) * | 2001-11-16 | 2003-10-02 | Steen Klysner | Novel immunogenic mimetics of multimer proteins |
-
2004
- 2004-05-06 EP EP04731308A patent/EP1625157A2/en not_active Withdrawn
- 2004-05-06 JP JP2006504380A patent/JP2007523605A/ja active Pending
- 2004-05-06 EA EA200501773A patent/EA008254B1/ru not_active IP Right Cessation
- 2004-05-06 CA CA002524623A patent/CA2524623A1/en not_active Abandoned
- 2004-05-06 MX MXPA05011965A patent/MXPA05011965A/es unknown
- 2004-05-06 WO PCT/DK2004/000329 patent/WO2004099244A2/en active Search and Examination
- 2004-05-06 NZ NZ543976A patent/NZ543976A/en unknown
- 2004-05-06 KR KR1020057021347A patent/KR20060015595A/ko not_active Application Discontinuation
- 2004-05-06 AU AU2004235875A patent/AU2004235875A1/en not_active Abandoned
-
2005
- 2005-11-09 US US11/270,276 patent/US20060222624A1/en not_active Abandoned
- 2005-11-30 NO NO20055724A patent/NO20055724L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA200501773A1 (ru) | 2006-06-30 |
JP2007523605A (ja) | 2007-08-23 |
CA2524623A1 (en) | 2004-11-18 |
EP1625157A2 (en) | 2006-02-15 |
KR20060015595A (ko) | 2006-02-17 |
AU2004235875A1 (en) | 2004-11-18 |
US20060222624A1 (en) | 2006-10-05 |
WO2004099244A3 (en) | 2004-12-29 |
WO2004099244A2 (en) | 2004-11-18 |
EA008254B1 (ru) | 2007-04-27 |
NZ543976A (en) | 2008-04-30 |
MXPA05011965A (es) | 2006-02-02 |
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