EA200501667A1 - Рецепторный комплекс тканезащитных цитокинов, способы идентификации тканезащитных соединений и их применение - Google Patents
Рецепторный комплекс тканезащитных цитокинов, способы идентификации тканезащитных соединений и их применениеInfo
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- EA200501667A1 EA200501667A1 EA200501667A EA200501667A EA200501667A1 EA 200501667 A1 EA200501667 A1 EA 200501667A1 EA 200501667 A EA200501667 A EA 200501667A EA 200501667 A EA200501667 A EA 200501667A EA 200501667 A1 EA200501667 A1 EA 200501667A1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Настоящее изобретение связано со способами идентификации соединений, которые оказывают тканезащитную активность с помощью гетеромультимерного рецепторного комплекса, которым опосредована тканезащитная активность. Этот комплекс состоит по меньшей мере из одного EPO-R в составе этого комплекса и по меньшей мере из одного β-рецептора. Указанные соединения используются в анализах по идентификации тканезащитных соединений, включая, без ограничения, малые молекулы и биологически активные вещества. Соединения, идентифицированные с помощью указанных анализов, могут быть использованы для лечения или предупреждения различных заболеваний, нарушений или состояний центральной и периферической нервной систем, а также систем других эритропоэтин-чувствительных или возбудимых клеток, тканей и органов.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46589103P | 2003-04-25 | 2003-04-25 | |
US10/676,694 US7718363B2 (en) | 2003-04-25 | 2003-09-30 | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
PCT/US2004/013099 WO2004096148A2 (en) | 2003-04-25 | 2004-04-26 | Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501667A1 true EA200501667A1 (ru) | 2006-06-30 |
EA009745B1 EA009745B1 (ru) | 2008-04-28 |
Family
ID=33303293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501667A EA009745B1 (ru) | 2003-04-25 | 2004-04-26 | Рецепторный комплекс тканезащитных цитокинов, способы идентификации тканезащитных соединений и их применение |
Country Status (13)
Country | Link |
---|---|
US (2) | US7718363B2 (ru) |
EP (1) | EP1622570A4 (ru) |
JP (1) | JP2006524827A (ru) |
KR (1) | KR20050121270A (ru) |
AU (1) | AU2004233985A1 (ru) |
BR (1) | BRPI0409678A (ru) |
CA (1) | CA2523578A1 (ru) |
EA (1) | EA009745B1 (ru) |
IS (1) | IS8075A (ru) |
MX (1) | MXPA05011134A (ru) |
NO (1) | NO20055525L (ru) |
NZ (1) | NZ543192A (ru) |
WO (1) | WO2004096148A2 (ru) |
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-
2003
- 2003-09-30 US US10/676,694 patent/US7718363B2/en not_active Expired - Fee Related
-
2004
- 2004-04-26 EP EP04760431A patent/EP1622570A4/en not_active Withdrawn
- 2004-04-26 KR KR1020057020323A patent/KR20050121270A/ko not_active Application Discontinuation
- 2004-04-26 WO PCT/US2004/013099 patent/WO2004096148A2/en active Application Filing
- 2004-04-26 US US10/554,517 patent/US20090136519A1/en not_active Abandoned
- 2004-04-26 NZ NZ543192A patent/NZ543192A/en unknown
- 2004-04-26 EA EA200501667A patent/EA009745B1/ru not_active IP Right Cessation
- 2004-04-26 JP JP2006513398A patent/JP2006524827A/ja active Pending
- 2004-04-26 MX MXPA05011134A patent/MXPA05011134A/es not_active Application Discontinuation
- 2004-04-26 CA CA002523578A patent/CA2523578A1/en not_active Abandoned
- 2004-04-26 BR BRPI0409678-9A patent/BRPI0409678A/pt not_active IP Right Cessation
- 2004-04-26 AU AU2004233985A patent/AU2004233985A1/en not_active Abandoned
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2005
- 2005-10-14 IS IS8075A patent/IS8075A/is unknown
- 2005-11-23 NO NO20055525A patent/NO20055525L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2006524827A (ja) | 2006-11-02 |
WO2004096148A2 (en) | 2004-11-11 |
MXPA05011134A (es) | 2006-05-25 |
EP1622570A4 (en) | 2009-07-08 |
US20090136519A1 (en) | 2009-05-28 |
WO2004096148A3 (en) | 2006-03-02 |
EP1622570A2 (en) | 2006-02-08 |
US7718363B2 (en) | 2010-05-18 |
NO20055525L (no) | 2006-01-16 |
CA2523578A1 (en) | 2004-11-11 |
NZ543192A (en) | 2008-07-31 |
NO20055525D0 (no) | 2005-11-23 |
BRPI0409678A (pt) | 2006-05-02 |
IS8075A (is) | 2005-10-14 |
EA009745B1 (ru) | 2008-04-28 |
AU2004233985A1 (en) | 2004-11-11 |
KR20050121270A (ko) | 2005-12-26 |
US20040214236A1 (en) | 2004-10-28 |
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