EA200501204A1 - Производные 3-(1-[3-(1,3-бензотиазол-6-ил)пропилкарбамоил]циклоалкил)пропановой кислоты в качестве ингибиторов нейтральной эндопептидазы (nep) - Google Patents

Производные 3-(1-[3-(1,3-бензотиазол-6-ил)пропилкарбамоил]циклоалкил)пропановой кислоты в качестве ингибиторов нейтральной эндопептидазы (nep)

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Publication number
EA200501204A1
EA200501204A1 EA200501204A EA200501204A EA200501204A1 EA 200501204 A1 EA200501204 A1 EA 200501204A1 EA 200501204 A EA200501204 A EA 200501204A EA 200501204 A EA200501204 A EA 200501204A EA 200501204 A1 EA200501204 A1 EA 200501204A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
nep
neutral endopeptidase
propylkarbamoil
benzotiazol
Prior art date
Application number
EA200501204A
Other languages
English (en)
Inventor
Дейвид Хепуэрт
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0305916A external-priority patent/GB0305916D0/en
Priority claimed from GB0329143A external-priority patent/GB0329143D0/en
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA200501204A1 publication Critical patent/EA200501204A1/ru

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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Abstract

Данное изобретение относится к ингибиторам фермента, представляющего собой нейтральную эндопептидазу (NEP), формулы (I), их применению, способам их получения, промежуточным соединениям, используемым в их получении, и композициям, содержащим указанные ингибиторы. Эти ингибиторы полезны в различных областях терапии, включая лечение мужской и женской сексуальной дисфункции, в частности женской сексуальной дисфункции (FSD), особенно когда FSD представляет собой расстройство полового возбуждения у женщины (FSAD).
EA200501204A 2003-03-14 2004-03-09 Производные 3-(1-[3-(1,3-бензотиазол-6-ил)пропилкарбамоил]циклоалкил)пропановой кислоты в качестве ингибиторов нейтральной эндопептидазы (nep) EA200501204A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0305916A GB0305916D0 (en) 2003-03-14 2003-03-14 New N-phenpropylcyclopentyl-substituted glutaramide derivatives as NEP inhibitors
GB0329143A GB0329143D0 (en) 2003-12-16 2003-12-16 Novel pharmaceuticals
PCT/IB2004/000822 WO2004080985A1 (en) 2003-03-14 2004-03-09 3-(1-[3-(1,3-benzothiazol-6-yl)propylcarbamoyl]cycloalkyl)propanoic acid derivatives as nep inhibitors

Publications (1)

Publication Number Publication Date
EA200501204A1 true EA200501204A1 (ru) 2006-06-30

Family

ID=32992599

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501204A EA200501204A1 (ru) 2003-03-14 2004-03-09 Производные 3-(1-[3-(1,3-бензотиазол-6-ил)пропилкарбамоил]циклоалкил)пропановой кислоты в качестве ингибиторов нейтральной эндопептидазы (nep)

Country Status (25)

Country Link
US (1) US20040180941A1 (ru)
EP (1) EP1606272A1 (ru)
JP (1) JP3923512B2 (ru)
KR (1) KR20050110003A (ru)
AP (1) AP2005003393A0 (ru)
AR (1) AR043551A1 (ru)
AU (1) AU2004220269A1 (ru)
BR (1) BRPI0408377A (ru)
CA (1) CA2519072A1 (ru)
CL (1) CL2004000512A1 (ru)
EA (1) EA200501204A1 (ru)
EC (1) ECSP056017A (ru)
HR (1) HRP20050797A2 (ru)
IS (1) IS8003A (ru)
MA (1) MA27720A1 (ru)
MX (1) MXPA05009788A (ru)
NL (1) NL1025709C2 (ru)
NO (1) NO20054169L (ru)
OA (1) OA13039A (ru)
PA (1) PA8597401A1 (ru)
PE (1) PE20050310A1 (ru)
TN (1) TNSN05227A1 (ru)
TW (1) TW200504038A (ru)
UY (1) UY28226A1 (ru)
WO (1) WO2004080985A1 (ru)

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US20130131007A1 (en) 2005-09-07 2013-05-23 Bebaas, Inc. Vitamin b12 compositions
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CN112997258A (zh) * 2018-06-14 2021-06-18 阿斯利康(英国)有限公司 用cGMP特异性磷酸二酯酶5抑制剂药物组合物治疗勃起功能障碍的方法
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NO20054169D0 (no) 2005-09-07
NL1025709A1 (nl) 2004-09-16
ECSP056017A (es) 2006-01-27
EP1606272A1 (en) 2005-12-21
KR20050110003A (ko) 2005-11-22
PE20050310A1 (es) 2005-05-04
MA27720A1 (fr) 2006-01-02
TW200504038A (en) 2005-02-01
HRP20050797A2 (en) 2006-02-28
IS8003A (is) 2005-08-29
PA8597401A1 (es) 2005-05-24
AR043551A1 (es) 2005-08-03
TNSN05227A1 (fr) 2007-06-11
NO20054169L (no) 2005-12-07
AP2005003393A0 (en) 2005-09-30
UY28226A1 (es) 2004-11-08
BRPI0408377A (pt) 2006-03-21
JP3923512B2 (ja) 2007-06-06
MXPA05009788A (es) 2005-10-26
US20040180941A1 (en) 2004-09-16
JP2006526572A (ja) 2006-11-24
AU2004220269A1 (en) 2004-09-23
NL1025709C2 (nl) 2005-03-14
CL2004000512A1 (es) 2005-01-21
OA13039A (en) 2006-11-10
WO2004080985A1 (en) 2004-09-23
CA2519072A1 (en) 2004-09-23

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