EA200500974A1 - Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала - Google Patents
Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного каналаInfo
- Publication number
- EA200500974A1 EA200500974A1 EA200500974A EA200500974A EA200500974A1 EA 200500974 A1 EA200500974 A1 EA 200500974A1 EA 200500974 A EA200500974 A EA 200500974A EA 200500974 A EA200500974 A EA 200500974A EA 200500974 A1 EA200500974 A1 EA 200500974A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ion channel
- polypeptide
- antigensorating
- antibody
- potential
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 101000962322 Homo sapiens Sodium leak channel NALCN Proteins 0.000 abstract 3
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 102100039242 Sodium leak channel NALCN Human genes 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к антителу или антигенсвязывающему домену, специфически связывающимся с полипептидом потенциалзависимого воротного ионного канала, к их применению для диагностики шизофрении или биполярного расстройства, к набору антисмысловых последовательностей, ингибирующих экспрессию ионного канала, к соединению, которое активирует или ингибирует экспрессию или активность ионного канала указанного полипептида, к фармацевтической композиции, содержащей антитело или антигенсвязывающий фрагмент, набор антисмысловых последовательностей или такое соединение и к диагностическому набору для диагностики шизофрении или биполярного расстройства.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25131700P | 2000-12-05 | 2000-12-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500974A1 true EA200500974A1 (ru) | 2006-02-24 |
EA008252B1 EA008252B1 (ru) | 2007-04-27 |
Family
ID=22951418
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500974A EA008252B1 (ru) | 2000-12-05 | 2001-12-04 | Антитело или антигенсвязывающий домен, специфически связывающиеся с полипептидом потенциалзависимого воротного ионного канала |
EA200300642A EA006367B1 (ru) | 2000-12-05 | 2001-12-04 | Связанные с шизофренией ген и белок потенциалзависимого воротного ионного канала |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300642A EA006367B1 (ru) | 2000-12-05 | 2001-12-04 | Связанные с шизофренией ген и белок потенциалзависимого воротного ионного канала |
Country Status (16)
Country | Link |
---|---|
US (2) | US20040091497A1 (ru) |
EP (1) | EP1339840B1 (ru) |
JP (1) | JP2004525614A (ru) |
KR (1) | KR20030074643A (ru) |
CN (1) | CN1777676A (ru) |
AT (1) | ATE339500T1 (ru) |
AU (2) | AU3357302A (ru) |
BR (1) | BR0115937A (ru) |
CA (1) | CA2430712A1 (ru) |
DE (1) | DE60123109T2 (ru) |
EA (2) | EA008252B1 (ru) |
ES (1) | ES2271092T3 (ru) |
IL (1) | IL156073A0 (ru) |
MX (1) | MXPA03005069A (ru) |
UA (1) | UA79927C2 (ru) |
WO (1) | WO2002046404A2 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020042100A1 (en) * | 2000-07-03 | 2002-04-11 | Chunhua Yan | Isolated human ion channel proteins, nucleic acid molecules encoding human ion channel proteins, and uses thereof |
WO2002101035A1 (fr) * | 2001-05-10 | 2002-12-19 | Mochida Pharmaceutical Co., Ltd. | Proteine du canal cation dependant du potentiel |
US7634363B2 (en) | 2005-12-07 | 2009-12-15 | Affymetrix, Inc. | Methods for high throughput genotyping |
GB2449819A (en) * | 2006-02-28 | 2008-12-03 | Univ California | Genes differentially expressed in bipolar disorder and/or schizophrenia |
FR2906532B1 (fr) * | 2006-09-28 | 2008-12-12 | Biomerieux Sa | Nouvel oligonucleotide marque |
EP3207051A4 (en) * | 2014-10-13 | 2018-02-28 | Dow AgroSciences LLC | Copi coatomer alpha subunit nucleic acid molecules that confer resistance to coleopteran and hemipteran pests |
KR20210087830A (ko) * | 2020-01-03 | 2021-07-13 | 삼성전자주식회사 | 기판 적층 구조를 포함하는 전자 장치 |
CN114982679B (zh) * | 2022-07-22 | 2023-08-01 | 中国水产科学研究院长江水产研究所 | 一种黄鳝家系建立及优良家系选育方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008001A (en) * | 1993-11-05 | 1999-12-28 | Yeda Research And Development Co. Ltd. | Diagnosis of the susceptibility of contracting schizophrenia |
CA2298474A1 (en) * | 1997-07-22 | 1999-02-04 | Millenium Pharmaceuticals, Inc. | Methods and compositions for the diagnosis and treatment of neuropsychiatric disorders |
AU760309B2 (en) * | 1997-12-03 | 2003-05-15 | Merck & Co., Inc. | Low-voltage activated calcium channel compositions and methods |
WO1999057316A1 (en) * | 1998-04-30 | 1999-11-11 | Institut Pasteur | A highly conserved polynucleotide sequence linked to a genetic predisposition to schizophrenia, a method of diagnosis, and applications thereof |
JP2002518010A (ja) * | 1998-06-16 | 2002-06-25 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 94個のヒト分泌タンパク質 |
WO2000022122A2 (en) * | 1998-10-13 | 2000-04-20 | Genset | Genes, proteins and biallelic markers related to central nervous system disease |
WO2000058510A2 (en) * | 1999-03-30 | 2000-10-05 | Genset | Schizophrenia associated genes, proteins and biallelic markers |
EP1280902A2 (en) * | 2000-04-29 | 2003-02-05 | Millennium Pharmaceuticals, Inc. | 23949 and 32391, human ion channels and uses thereof |
CA2415808A1 (en) * | 2000-07-07 | 2002-01-17 | Incyte Genomics, Inc. | Transporters and ion channels |
-
2001
- 2001-04-12 UA UA2003076265A patent/UA79927C2/uk unknown
- 2001-12-04 EA EA200500974A patent/EA008252B1/ru not_active IP Right Cessation
- 2001-12-04 AU AU3357302A patent/AU3357302A/xx active Pending
- 2001-12-04 CN CNA018224997A patent/CN1777676A/zh active Pending
- 2001-12-04 CA CA002430712A patent/CA2430712A1/en not_active Abandoned
- 2001-12-04 MX MXPA03005069A patent/MXPA03005069A/es active IP Right Grant
- 2001-12-04 ES ES01984902T patent/ES2271092T3/es not_active Expired - Lifetime
- 2001-12-04 EP EP01984902A patent/EP1339840B1/en not_active Expired - Lifetime
- 2001-12-04 AT AT01984902T patent/ATE339500T1/de not_active IP Right Cessation
- 2001-12-04 KR KR10-2003-7007511A patent/KR20030074643A/ko active IP Right Grant
- 2001-12-04 AU AU2002233573A patent/AU2002233573B2/en not_active Ceased
- 2001-12-04 DE DE60123109T patent/DE60123109T2/de not_active Expired - Fee Related
- 2001-12-04 IL IL15607301A patent/IL156073A0/xx unknown
- 2001-12-04 JP JP2002548121A patent/JP2004525614A/ja active Pending
- 2001-12-04 WO PCT/IB2001/002798 patent/WO2002046404A2/en active IP Right Grant
- 2001-12-04 EA EA200300642A patent/EA006367B1/ru not_active IP Right Cessation
- 2001-12-04 BR BR0115937-2A patent/BR0115937A/pt not_active IP Right Cessation
- 2001-12-04 US US10/433,580 patent/US20040091497A1/en not_active Abandoned
-
2008
- 2008-03-18 US US12/050,492 patent/US20080184381A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA03005069A (es) | 2003-09-05 |
EA008252B1 (ru) | 2007-04-27 |
WO2002046404A3 (en) | 2002-12-12 |
CA2430712A1 (en) | 2002-06-13 |
ATE339500T1 (de) | 2006-10-15 |
US20080184381A1 (en) | 2008-07-31 |
EA200300642A1 (ru) | 2003-12-25 |
CN1777676A (zh) | 2006-05-24 |
UA79927C2 (en) | 2007-08-10 |
US20040091497A1 (en) | 2004-05-13 |
WO2002046404A9 (en) | 2002-08-15 |
AU3357302A (en) | 2002-06-18 |
WO2002046404A2 (en) | 2002-06-13 |
DE60123109D1 (de) | 2006-10-26 |
IL156073A0 (en) | 2003-12-23 |
KR20030074643A (ko) | 2003-09-19 |
ES2271092T3 (es) | 2007-04-16 |
EP1339840B1 (en) | 2006-09-13 |
EP1339840A2 (en) | 2003-09-03 |
AU2002233573B2 (en) | 2007-03-01 |
BR0115937A (pt) | 2003-09-30 |
JP2004525614A (ja) | 2004-08-26 |
DE60123109T2 (de) | 2007-05-16 |
EA006367B1 (ru) | 2005-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |