EA200500819A1 - Способы стабилизации аторвастатина - Google Patents

Способы стабилизации аторвастатина

Info

Publication number
EA200500819A1
EA200500819A1 EA200500819A EA200500819A EA200500819A1 EA 200500819 A1 EA200500819 A1 EA 200500819A1 EA 200500819 A EA200500819 A EA 200500819A EA 200500819 A EA200500819 A EA 200500819A EA 200500819 A1 EA200500819 A1 EA 200500819A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kpa
stabilization
preferably less
partial pressure
gaseous mixture
Prior art date
Application number
EA200500819A
Other languages
English (en)
Other versions
EA007345B1 (ru
Inventor
Павел Себек
Алена Прокопова
Эдуард Свобода
Станислав Радл
Ян Стах
Мартин Свобода
Андрей Ковацик
Андриан Данко
Роман Петро
Мирослав Стризинек
Original Assignee
Зентива А. С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34117186&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500819(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CZ20032135A external-priority patent/CZ295027B6/cs
Priority claimed from CZ20040857A external-priority patent/CZ296181B6/cs
Application filed by Зентива А. С. filed Critical Зентива А. С.
Publication of EA200500819A1 publication Critical patent/EA200500819A1/ru
Publication of EA007345B1 publication Critical patent/EA007345B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Изобретение относится к способам стабилизации фармацевтически активного твердого вещества аторвастатина, одного или в смеси с другими твердыми веществами, помещенного в газовую смесь, в соответствии с которыми в этой окружающей газовой смеси поддерживают парциальное давление кислорода не более 2 кПа, предпочтительно меньше 1 кПа, более предпочтительно меньше 0,4 кПа. Соответствующее парциальное давление достигают либо с использованием абсорберов кислорода, либо упаковкой под давлением 0,3-10 кПа, либо упаковкой под легким избыточным давлением инертного газа, предпочтительно азота, который подают через насадки во впадины, возможно также и в пространство прессующего вальца сварной камеры.Отчет о международном поиске был опубликован 2005.10.20.
EA200500819A 2003-08-05 2004-08-05 Способы стабилизации аторвастатина EA007345B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20032135A CZ295027B6 (cs) 2003-08-05 2003-08-05 Způsob stabilizace farmaceutické kompozice
CZ20040857A CZ296181B6 (cs) 2004-08-03 2004-08-03 Zpusob stabilizace farmaceutické úcinné tuhé látky atorvastatinu
PCT/CZ2004/000045 WO2005011638A2 (en) 2003-08-05 2004-08-05 Methods for the stabilization of atorvastatin

Publications (2)

Publication Number Publication Date
EA200500819A1 true EA200500819A1 (ru) 2006-02-24
EA007345B1 EA007345B1 (ru) 2006-08-25

Family

ID=34117186

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500819A EA007345B1 (ru) 2003-08-05 2004-08-05 Способы стабилизации аторвастатина

Country Status (13)

Country Link
US (1) US20080171784A1 (ru)
EP (1) EP1653930B1 (ru)
AT (1) ATE381322T1 (ru)
CA (1) CA2535225A1 (ru)
DE (1) DE602004010817T2 (ru)
EA (1) EA007345B1 (ru)
ES (1) ES2298763T3 (ru)
HR (1) HRP20060089B1 (ru)
PL (2) PL1653930T3 (ru)
PT (1) PT1653930E (ru)
RS (1) RS20060081A (ru)
SK (1) SK50462005A3 (ru)
WO (1) WO2005011638A2 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2579997A1 (en) * 2004-09-28 2006-04-06 Teva Pharmaceutical Industries Ltd. Process for preparing forms of atorvastatin calcium substantially free of impurities
TWI318571B (en) * 2005-06-10 2009-12-21 Lilly Co Eli Formulation of a thienopyridine platelet aggregation inhibitor
EP1741427A1 (en) * 2005-07-06 2007-01-10 KRKA, D.D., Novo Mesto Pharmaceutical composition comprising simvastatin and ezetimibe
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
CZ300047B6 (cs) * 2007-03-02 2009-01-21 Zentiva, A. S. Farmaceutická kompozice s obsahem úcinné látky atorvastatinu
EP2127628A1 (en) 2008-05-27 2009-12-02 Ranbaxy Laboratories Limited Unit dose pack
TR200806300A2 (tr) * 2008-08-22 2010-03-22 B�Lg�� Mahmut Çözünürlük artırıcı farmasötlk formulasyon
EP2522348B1 (en) 2009-12-25 2016-05-25 Sawai Pharmaceutical Co., Ltd. Atorvastatin-containing coated preparation
US9717707B2 (en) 2011-12-08 2017-08-01 Hexal Ag Pharmaceutical statin composition
TWI636783B (zh) * 2012-04-18 2018-10-01 友霖生技醫藥股份有限公司 含匹伐他汀（ｐｉｔａｖａｓｔａｔｉｎ）穩定配方的醫藥組合物
PT2968729T (pt) 2013-03-14 2018-11-06 Fresenius Kabi Deutschland Gmbh Sistema de acondicionamento para fármacos sensíveis ao oxigénio
BR112015021586B1 (pt) 2013-03-14 2023-01-31 Fresenius Kabi Deutschland Gmbh Formulação de morfina farmacêutica injetável e kit
EP3184103A1 (en) 2015-12-21 2017-06-28 Hexal AG Pharmaceutical composition comprising atorvastatin or a salt thereof
EP3272336A1 (de) 2016-07-19 2018-01-24 Stada Arzneimittel Ag Atorvastatin-zusammensetzung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
JP3254219B2 (ja) * 1993-01-19 2002-02-04 ワーナー−ランバート・コンパニー 安定な経口用のｃｉ−９８１製剤およびその製法
CZ20024015A3 (cs) * 2000-06-09 2003-04-16 Lek Pharmaceutical D.D. Stabilní farmaceutický produkt a jeho formulace
EP1243524A3 (en) * 2001-03-16 2004-04-07 Pfizer Products Inc. Pharmaceutical kit for oxygen-sensitive drugs
EP1241110A1 (en) * 2001-03-16 2002-09-18 Pfizer Products Inc. Dispensing unit for oxygen-sensitive drugs
KR20040101229A (ko) * 2002-02-14 2004-12-02 랜박시 래보러터리스 리미티드 알칼리 금속 첨가에 의해 안정화된 아토르바스타틴 배합물
SI21302A (sl) * 2002-10-11 2004-04-30 LEK farmacevtska dru�ba d.d. Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino

Also Published As

Publication number Publication date
ATE381322T1 (de) 2008-01-15
HRP20060089B1 (en) 2008-05-31
WO2005011638A2 (en) 2005-02-10
EP1653930B1 (en) 2007-12-19
DE602004010817T2 (de) 2008-12-11
DE602004010817D1 (de) 2008-01-31
EP1653930A2 (en) 2006-05-10
PT1653930E (pt) 2008-03-12
HRP20060089A2 (en) 2006-05-31
SK50462005A3 (sk) 2005-09-08
PL379195A1 (pl) 2006-07-24
EA007345B1 (ru) 2006-08-25
WO2005011638A3 (en) 2005-10-20
US20080171784A1 (en) 2008-07-17
ES2298763T3 (es) 2008-05-16
CA2535225A1 (en) 2005-02-10
PL1653930T3 (pl) 2008-06-30
RS20060081A (en) 2008-06-05

Similar Documents

Publication Publication Date Title
HRP20060089B1 (en) Method for the stabilization of atorvastatin
CA2489956A1 (en) Generation of elevated pressure gas mixtures by adsorption and stripping
UA85715C2 (ru) упакованная изоляционная продукция и способ упаковки изоляционной продукции
AR022866A1 (es) Conjunto que comprende una bebida envasada lista para beber y dicha bebida envasada lista para beber.
IN2014DN07569A (ru)
RS20050273A (en) Stabilized pharmaceutical preparation comprising an amorphous active substance
MXPA03000001A (es) Nuevo metodo para obtener formulaciones acuosas con principios activos susceptibles a oxidacion y las soluciones acuosas obtenidas de este modo.
WO2005122774A3 (en) Packaging of meat prodcuts with modified atmospheres and/or enhancers
SG48702A1 (en) Method for manufacturing and storing stable bicarbonate solutions
WO2009041049A1 (ja) 殺菌方法および装置
MX295630B (es) Proceso de multi-microencapsulacion continuo para la mejora de la estabilidad y almacenamiento de ingredientes biologicamente activos.
PT1326630E (pt) Utilização de péptidos glp-2
DE602005026905D1 (de) Produktabgabesystem und dessen herstellungsverfahren
HRP20070487T3 (en) Preparing aldesleukin for pharmaceutical use
WO2007044835A3 (en) Apparatus, system, and method for storage of mushrooms
WO2003037388A3 (en) System and method for de-contaminating and/or sanitizing
MY141989A (en) Drug delivery assembly
EP1900641A3 (en) System for packaging minimally processed fresh vegetable products
WO2006121891A3 (en) Medical devices and methods of making the same
WO2002026059A3 (en) Method for preserving food products using biological modified atmosphere packaging
WO2008079947A3 (en) Gaseous sterilization of impermeable containers through use of porous material
CA2489738A1 (en) Modified atmosphere packaging for seafood
BR0114946A (pt) Processo e instalação e acondicionamento de produto lìquido em uma embalagem
ITMI20001797A0 (it) Procedimento e dispositivo per la produzione, mediante adsorbimento, di azoto a purezza prefissata e costante.
WO2005037653A9 (es) Procedimiento ecológico para la reducción del volumen de bloques de material elástico poroso y empacadura conjunta para su almacenaje y transporte

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title