EA200500546A1 - Частицы, покрытые нуклеиновой кислотой - Google Patents

Частицы, покрытые нуклеиновой кислотой

Info

Publication number
EA200500546A1
EA200500546A1 EA200500546A EA200500546A EA200500546A1 EA 200500546 A1 EA200500546 A1 EA 200500546A1 EA 200500546 A EA200500546 A EA 200500546A EA 200500546 A EA200500546 A EA 200500546A EA 200500546 A1 EA200500546 A1 EA 200500546A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nucleic acid
particles
methods
particles coated
delivery
Prior art date
Application number
EA200500546A
Other languages
English (en)
Other versions
EA010881B1 (ru
Inventor
Крис Роберт Лайвли
Роберт Делонг
Original Assignee
Паудерджект Рисерч Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32043345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500546(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Паудерджект Рисерч Лимитед filed Critical Паудерджект Рисерч Лимитед
Publication of EA200500546A1 publication Critical patent/EA200500546A1/ru
Publication of EA010881B1 publication Critical patent/EA010881B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Plant Pathology (AREA)
  • Ceramic Engineering (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Предлагаются частицы, которые пригодны для доставки из устройства для опосредуемой частицами доставки. Частицы получают путем осаждения нуклеиновой кислоты на частицах-носителях из инертного металла в присутствии агента, конденсирующего нуклеиновую кислоту, и агента, хелатирующего ионы металла. Также описаны способы получения частиц и способы терапии с применением частиц, включая способы иммунизации нуклеиновой кислотой и генной терапии.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500546A 2002-09-27 2003-09-29 Частицы, покрытые нуклеиновой кислотой EA010881B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41409702P 2002-09-27 2002-09-27
PCT/GB2003/004202 WO2004028560A1 (en) 2002-09-27 2003-09-29 Nucleic acid coated particles

Publications (2)

Publication Number Publication Date
EA200500546A1 true EA200500546A1 (ru) 2005-10-27
EA010881B1 EA010881B1 (ru) 2008-12-30

Family

ID=32043345

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500546A EA010881B1 (ru) 2002-09-27 2003-09-29 Частицы, покрытые нуклеиновой кислотой

Country Status (17)

Country Link
US (1) US8349364B2 (ru)
EP (1) EP1545593A1 (ru)
JP (1) JP4791730B2 (ru)
KR (1) KR101152561B1 (ru)
CN (1) CN100542605C (ru)
AU (1) AU2003269213B2 (ru)
BR (1) BR0314751A (ru)
CA (1) CA2500215C (ru)
EA (1) EA010881B1 (ru)
GB (1) GB2410497B (ru)
HK (1) HK1073797A1 (ru)
IL (1) IL167635A (ru)
MX (1) MXPA05003222A (ru)
NZ (1) NZ539107A (ru)
PL (1) PL212483B1 (ru)
WO (1) WO2004028560A1 (ru)
ZA (1) ZA200503380B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2513747C (en) 2003-01-24 2017-03-07 University Of Utah Methods of predicting mortality risk by determining telomere length
JP4793956B2 (ja) * 2005-12-29 2011-10-12 ニチコン株式会社 アルミニウム電解コンデンサの駆動用電解液、およびこれを用いたアルミニウム電解コンデンサ
EP2379747B1 (en) 2008-12-22 2013-07-03 University of Utah Research Foundation Monochrome multiplex quantitative pcr
GB0918679D0 (en) 2009-10-23 2009-12-09 Iqur Ltd Influenza vaccine
GB0918782D0 (en) 2009-10-26 2009-12-09 St Georges Hosp Medical School A protein as an adjuvant for a vaccine
CA2914555A1 (en) 2013-06-06 2014-12-11 David J Rowlands Single domain antibody display
CN103736090B (zh) * 2014-01-27 2016-03-02 中国医学科学院医学生物学研究所 甲磺酸去铁胺佐剂及含甲磺酸去铁胺佐剂的疫苗
WO2016000792A1 (en) * 2014-07-04 2016-01-07 Biontech Ag Stabilised formulations of rna
US9944978B2 (en) 2014-12-30 2018-04-17 Telomere Diagnostics, Inc. Multiplex quantitative PCR
US11326164B2 (en) 2019-09-29 2022-05-10 Wjwu & Lynn Institute For Stem Cell Research Trimethylglycylglycerin compositions and their use in developing anti-cancer drugs and RNA vaccines

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5120657A (en) 1986-12-05 1992-06-09 Agracetus, Inc. Apparatus for genetic transformation
KR900007952B1 (ko) 1988-11-18 1990-10-23 주식회사 녹십자 신규의 한탄바이러스 rok84/105 균주 및 이를 이용한 한탄바이러스 백신의 제조방법
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5149655A (en) 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
CA2051092C (en) * 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
WO1992020809A1 (en) * 1991-05-15 1992-11-26 Agracetus, Inc. Method of creating a transformed rice plant
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
AU674815B2 (en) 1994-01-21 1997-01-09 Powderject Vaccines, Inc. Gas driven gene delivery instrument
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
AU3703895A (en) 1994-10-24 1996-05-15 Oxford Biosciences Limited Particle delivery
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
DE69732029T2 (de) 1996-04-26 2006-02-23 Merck & Co., Inc. Dna enthaltende impfstoffen
IN184589B (ru) 1996-10-16 2000-09-09 Alza Corp
CA2336992A1 (en) 1998-07-09 2000-01-20 Merck & Co., Inc. Polynucleotide vaccine formulations
PT1119630E (pt) * 1998-11-05 2006-05-31 Powderject Vaccines Inc Construcoes de acido nucleico para imunizacao genetica
WO2000072908A1 (en) * 1999-06-02 2000-12-07 Microheart, Inc. Devices and methods for delivering a drug
AU2001252390A1 (en) * 2000-05-01 2001-11-12 Powderject Vaccines, Inc. Nucleic acid immunization
EP1292285A4 (en) * 2000-06-02 2009-07-22 Eisai Corp North America SYSTEMS FOR DISPENSING BIOACTIVE AGENTS

Also Published As

Publication number Publication date
JP4791730B2 (ja) 2011-10-12
MXPA05003222A (es) 2005-07-26
CA2500215A1 (en) 2004-04-08
GB2410497A (en) 2005-08-03
IL167635A (en) 2011-07-31
EP1545593A1 (en) 2005-06-29
US20060153804A1 (en) 2006-07-13
PL375782A1 (en) 2005-12-12
GB0508549D0 (en) 2005-06-01
US8349364B2 (en) 2013-01-08
CN1694721A (zh) 2005-11-09
PL212483B1 (pl) 2012-10-31
KR101152561B1 (ko) 2012-06-01
BR0314751A (pt) 2005-07-26
GB2410497B (en) 2006-11-22
KR20050070008A (ko) 2005-07-05
HK1073797A1 (en) 2005-10-21
AU2003269213B2 (en) 2008-11-13
NZ539107A (en) 2008-11-28
JP2006503063A (ja) 2006-01-26
WO2004028560A1 (en) 2004-04-08
AU2003269213A1 (en) 2004-04-19
CA2500215C (en) 2012-02-28
EA010881B1 (ru) 2008-12-30
ZA200503380B (en) 2007-11-28
CN100542605C (zh) 2009-09-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU