EA200500006A1 - Лекарственное средство для лечения нейродегенеративных заболеваний - Google Patents

Лекарственное средство для лечения нейродегенеративных заболеваний

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Publication number
EA200500006A1
EA200500006A1 EA200500006A EA200500006A EA200500006A1 EA 200500006 A1 EA200500006 A1 EA 200500006A1 EA 200500006 A EA200500006 A EA 200500006A EA 200500006 A EA200500006 A EA 200500006A EA 200500006 A1 EA200500006 A1 EA 200500006A1
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EA
Eurasian Patent Office
Prior art keywords
group
formula
same meaning
conh
represented
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EA200500006A
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English (en)
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EA011707B1 (ru
Inventor
Сусуму Муто
Акико Итай
Original Assignee
Инститьют Оф Медисинал Молекьюлар Дизайн. Инк.
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Publication of EA200500006A1 publication Critical patent/EA200500006A1/ru
Publication of EA011707B1 publication Critical patent/EA011707B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Лекарственное средство для профилактики и/или терапевтического лечения нейродегенеративного заболевания, такого как болезнь Альцгеймера или тому подобное, которое содержит в качестве активного ингредиента вещество, выбранное из группы, состоящей из соединения, представленного общей формулой (I), и его фармакологически приемлемой соли, и его гидрата, и его сольватагде A представляет собой атом водорода или ацетильную группу, E представляет собой 2,5-дизамещенную или 3,5-дизамещенную фенильную группу или моноциклическую или конденсированную полициклическую гетероарильную группу, которая может быть замещенной, при условии, что исключено соединение, у которого указанная гетероарильная группа является (1) конденсированной полициклической гетероарильной группой, у которой кольцо, которое непосредственно связано с группой -CONH- в формуле (I), является бензольным кольцом, (2) незамещенной тиазол-2-ильной группой или (3) незамещенной бензотиазол-2-ильной группой, кольцо Z представляет собой арен, который может иметь один или несколько заместителей в дополнение к группе, представленной формулой -O-A, где A имеет такое же значение, как указано выше, и группе, представленной формулой -CONH-E, где E имеет такое же значение, как указано выше, или гетероарен, который может иметь один или несколько заместителей в дополнение к группе, представленной формулой -O-A, где A имеет такое же значение, как указано выше, и группе, представленной формулой -CONH-E, где E имеет такое же значение, как указано выше.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500006A 2002-06-11 2003-06-05 Лекарственное средство для лечения нейродегенеративных заболеваний EA011707B1 (ru)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263657B2 (en) * 2000-12-18 2012-09-11 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines
CA2470427C (en) 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
SI1466912T1 (sl) 2002-01-18 2013-08-30 Astellas Pharma Inc. Derivat 2-acilaminotiazola ali njegova sol
US7626042B2 (en) 2002-06-06 2009-12-01 Institute Of Medicinal Molecular Design, Inc. O-substituted hydroxyaryl derivatives
CA2488367A1 (en) 2002-06-06 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Antiallergic agents
CN100464742C (zh) * 2002-06-10 2009-03-04 株式会社医药分子设计研究所 NF-κB活化抑制剂
EP1542699A4 (en) 2002-07-15 2009-03-25 Myriad Genetics Inc COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
FR2849992B1 (fr) * 2003-01-17 2007-03-16 Inst Phytoceutic Composition pour une administration par voie orale contenant des capsaicinoides
EP1675812B1 (en) * 2003-10-14 2010-01-20 X-Ceptor Therapeutics, Inc. Bridged ring structures as pharmaceutical agents
EA013249B1 (ru) * 2003-12-26 2010-04-30 Киова Хакко Кирин Ко., Лтд. Производные тиазола
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
JP2011511077A (ja) * 2008-02-08 2011-04-07 ノースウエスタン ユニバーシティ 選択的ポリ−ｎ−置換グリシン抗生物質
US10640457B2 (en) 2009-12-10 2020-05-05 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
US9119878B2 (en) 2010-07-08 2015-09-01 Wellesley Pharmaceuticals, Llc Extended-release formulation for reducing the frequency of urination and method of use thereof
EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
US20140113898A1 (en) * 2010-11-08 2014-04-24 Zalicus Pharmaceuticals Ltd. Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers
US9969677B2 (en) 2010-12-22 2018-05-15 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase modulators and uses thereof
WO2013033037A2 (en) * 2011-08-26 2013-03-07 The Regents Of The University Of California Novel antiprion compounds
BR112014027983B1 (pt) 2012-05-08 2022-05-24 Aeromics, Inc Uso de inibidores de aquaporina seletivos
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
KR101717872B1 (ko) * 2013-03-12 2017-03-17 (주)바이오팜솔루션즈 소아 간질 및 간질-관련 증후군의 예방 또는 치료용 페닐카바메이트 화합물
US10596127B2 (en) 2013-03-14 2020-03-24 Wellesley Pharmaceuticals, Llc Composition for reducing the frequency of urination, method of making and use thereof
JP6083770B2 (ja) 2013-09-13 2017-02-22 板井　昭子 水溶液製剤及びその製造方法
AU2014346682B2 (en) 2013-11-06 2020-03-12 Aeromics, Inc. Novel formulations
JP2017538676A (ja) 2014-11-05 2017-12-28 ザ ユニバーシティ オブ カンザス ミトコンドリア透過性遷移孔（ｍｔＰＴＰ）の小分子阻害剤
US10980755B2 (en) * 2015-09-10 2021-04-20 The Regents Of The University Of California LRH-1 modulators
WO2019222393A1 (en) * 2018-05-15 2019-11-21 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Neuroprotective compositions and methods of using the same
WO2019241376A1 (en) * 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE615511A (ru) * 1961-03-25
NL292958A (ru) * 1962-05-29 1900-01-01
DE2120862A1 (de) * 1971-04-28 1972-11-09 Farbenfabriken Bayer Ag, 5090 Leverkusen 3,5-Disubstituierte 2-Acyloxybenzoesäureanilide, Verfahren zu ihrer Herstellung und ihre insektizide und akarizide Verwendung
US4358443A (en) * 1980-04-14 1982-11-09 The Research Foundation Of State University Of New York Method and composition for controlling the growth of microorganisms
JPS59118750A (ja) * 1982-12-27 1984-07-09 Eisai Co Ltd カルボン酸アミド化合物およびその誘導体
US4560549A (en) * 1983-08-24 1985-12-24 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4742083A (en) * 1983-08-24 1988-05-03 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4725590A (en) * 1983-08-24 1988-02-16 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
JPS6230780A (ja) * 1985-04-17 1987-02-09 Ss Pharmaceut Co Ltd １，７−ナフチリジン誘導体及びこれを含有する薬剤
US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
US4966906A (en) * 1987-11-27 1990-10-30 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-isoquinolinecarboxamides
US4952588A (en) * 1987-11-27 1990-08-28 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
US5192753A (en) * 1991-04-23 1993-03-09 Mcgeer Patrick L Anti-rheumatoid arthritic drugs in the treatment of dementia
US6159988A (en) * 1992-01-16 2000-12-12 Hoeschst Aktiengesellschaft Arylcycloalkyl derivatives, their production and their use
CZ285937B6 (cs) * 1992-01-16 1999-12-15 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití
WO1996017832A1 (en) * 1994-12-07 1996-06-13 Warner-Lambert Company Novel glutamate receptor antagonists: fused cycloalkylquinoxalinediones
US5935966A (en) * 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5852028A (en) * 1995-12-18 1998-12-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
US5811428A (en) * 1995-12-18 1998-09-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
ITMI962356A1 (it) * 1996-11-13 1998-05-13 Uni Degli Studi Di Brescia D I Uso di composti derivati da molecole ad attivita' antinfiammatoria di tipo non steroideo per la prevenzione e il trattamento di
US6117859A (en) * 1997-11-04 2000-09-12 The Research Foundation Of State University Of New York Method of relieving chronic inflammation by using 5-alkylsulfonylsalicylanilides
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
AU2662899A (en) * 1998-02-13 1999-08-30 Medinox, Inc. Methods for the controlled delivery of carbon disulfide for the treatment of inflammatory conditions
US20020002199A1 (en) * 1998-03-12 2002-01-03 Lone Jeppesen Modulators of protein tyrosine phosphatases (ptpases)
WO1999046244A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
US6262044B1 (en) * 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)
US20020019412A1 (en) * 1998-03-12 2002-02-14 Henrik Sune Andersen Modulators of protein tyrosine phosphatases (ptpases)
WO1999046236A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
WO1999046267A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
US6225329B1 (en) * 1998-03-12 2001-05-01 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPases)
ES2255251T3 (es) * 1998-03-20 2006-06-16 Daiichi Asubio Pharma Co., Ltd. Inhibidores de nf-kb que contienen derivados de benzoquinona.
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
SE9802549D0 (sv) * 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
ES2219033T3 (es) * 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
US6653309B1 (en) * 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
CA2381215A1 (en) * 1999-08-06 2001-02-15 Takeda Chemical Industries, Ltd. P38map kinase inhibitors
WO2001012588A1 (fr) * 1999-08-11 2001-02-22 Mercian Corporation Derives de salicylamide
US6787652B1 (en) * 1999-09-30 2004-09-07 Pfizer, Inc. 6-Azauracil derivatives as thyroid receptor ligands
US6706766B2 (en) * 1999-12-13 2004-03-16 President And Fellows Of Harvard College Small molecules used to increase cell death
US6414013B1 (en) * 2000-06-19 2002-07-02 Pharmacia & Upjohn S.P.A. Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
EP1182251A1 (en) * 2000-08-11 2002-02-27 Yissum Research Development Company of the Hebrew University of Jerusalem Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB
US8263657B2 (en) * 2000-12-18 2012-09-11 Institute Of Medicinal Molecular Design, Inc. Inhibitors against the production and release of inflammatory cytokines
KR20030064852A (ko) * 2000-12-22 2003-08-02 이시하라 산교 가부시끼가이샤 아닐린 유도체 또는 그의 염 및 이들을 함유하는사이토카인 생산 억제제
HUP0302479A2 (hu) * 2001-03-27 2003-11-28 Daiichi Suntory Biomedical Research Limited NF-kappa B gátló gyógyszerkészítmény, amely hatóanyagként helyettesített benzoesavszármazékot tartalmaz
WO2003103658A1 (ja) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 免疫関連プロテインキナーゼ阻害剤
EP1535610A4 (en) * 2002-06-10 2008-12-31 Inst Med Molecular Design Inc THERAPEUTIC CANCER

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TW200402290A (en) 2004-02-16
EP1555018A4 (en) 2009-01-07
CN1658858A (zh) 2005-08-24
WO2003103657A1 (ja) 2003-12-18
TWI280127B (en) 2007-05-01
JPWO2003103657A1 (ja) 2005-10-06
CA2488979A1 (en) 2003-12-18
EA011707B1 (ru) 2009-04-28
US20060035944A1 (en) 2006-02-16
CN100490793C (zh) 2009-05-27
EP1555018A1 (en) 2005-07-20
JP4635130B2 (ja) 2011-02-16
AU2003242124A1 (en) 2003-12-22

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