EA200401235A1 - Способ получения модафинила - Google Patents

Способ получения модафинила

Info

Publication number
EA200401235A1
EA200401235A1 EA200401235A EA200401235A EA200401235A1 EA 200401235 A1 EA200401235 A1 EA 200401235A1 EA 200401235 A EA200401235 A EA 200401235A EA 200401235 A EA200401235 A EA 200401235A EA 200401235 A1 EA200401235 A1 EA 200401235A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
modafinil
diphenylmethyl
sulfenyl
sulfinyl
Prior art date
Application number
EA200401235A
Other languages
English (en)
Other versions
EA007327B1 (ru
Inventor
Грациано Кастальди
Витторио Луккини
Антонио Тарквини
Original Assignee
ДИФАРМА С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДИФАРМА С.п.А. filed Critical ДИФАРМА С.п.А.
Publication of EA200401235A1 publication Critical patent/EA200401235A1/ru
Publication of EA007327B1 publication Critical patent/EA007327B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)

Abstract

Способ получения 2-[(дифенилметил)сульфинил]ацетамида (1), включающий окисление 2-[(дифенилметил)сульфенил]ацетата натрия до соответствующего сульфоксида и перевод последнего в амид.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401235A 2002-05-10 2003-04-23 Способ получения модафинила EA007327B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000991A ITMI20020991A1 (it) 2002-05-10 2002-05-10 Procedimento per la sintesi del modafinil
PCT/EP2003/004229 WO2003095423A1 (en) 2002-05-10 2003-04-23 A process for the preparation of modafinil

Publications (2)

Publication Number Publication Date
EA200401235A1 true EA200401235A1 (ru) 2005-06-30
EA007327B1 EA007327B1 (ru) 2006-08-25

Family

ID=11449867

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401235A EA007327B1 (ru) 2002-05-10 2003-04-23 Способ получения модафинила

Country Status (17)

Country Link
US (1) US7057068B2 (ru)
EP (1) EP1503983B1 (ru)
JP (1) JP4351626B2 (ru)
KR (1) KR20040108789A (ru)
AT (1) ATE364593T1 (ru)
AU (1) AU2003227668A1 (ru)
CA (1) CA2485428A1 (ru)
DE (1) DE60314410T2 (ru)
DK (1) DK1503983T3 (ru)
EA (1) EA007327B1 (ru)
ES (1) ES2286429T3 (ru)
IL (1) IL165121A0 (ru)
IT (1) ITMI20020991A1 (ru)
MX (1) MXPA04011141A (ru)
PL (1) PL371679A1 (ru)
PT (1) PT1503983E (ru)
WO (1) WO2003095423A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1309547B1 (en) 2000-07-27 2007-01-17 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
ITMI20051971A1 (it) * 2005-10-18 2007-04-19 Dipharma Spa Procedimento per la preparazione di - modafinil
JP2009508880A (ja) * 2006-02-21 2009-03-05 テバ ファーマシューティカル インダストリーズ リミティド アルモダフィニルの新規な結晶形とその調製方法
WO2007103221A2 (en) * 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
EP2043623A4 (en) * 2006-07-12 2013-03-20 Elan Pharma Int Ltd NANOPARTICLE FORMULATIONS OF MODAFINIL
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
EP1911739A3 (en) 2007-11-05 2008-09-17 Dipharma Francis S.r.l. Crystalline form of (S)-2-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
CN114044730B (zh) * 2021-11-26 2024-04-23 台州学院 一种亚砜类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE221261C (ru)
DE2546319C2 (de) 1975-10-16 1986-02-27 Dr. Karl Thomae Gmbh, 7950 Biberach Cyclohexylphenyl-Derivate, Verfahren zu deren Herstellung und diese enthaltende Mittel
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
US4964893A (en) * 1986-04-17 1990-10-23 Monsanto Company Benzhydryl compounds as herbicide antidotes
EP1309547B1 (en) 2000-07-27 2007-01-17 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same

Also Published As

Publication number Publication date
ITMI20020991A0 (it) 2002-05-10
ES2286429T3 (es) 2007-12-01
EA007327B1 (ru) 2006-08-25
EP1503983B1 (en) 2007-06-13
IL165121A0 (en) 2005-12-18
ITMI20020991A1 (it) 2003-11-10
PL371679A1 (en) 2005-06-27
US20050154063A1 (en) 2005-07-14
DE60314410T2 (de) 2008-02-14
KR20040108789A (ko) 2004-12-24
US7057068B2 (en) 2006-06-06
JP4351626B2 (ja) 2009-10-28
MXPA04011141A (es) 2005-07-01
WO2003095423A1 (en) 2003-11-20
DK1503983T3 (da) 2007-09-10
DE60314410D1 (de) 2007-07-26
ATE364593T1 (de) 2007-07-15
AU2003227668A1 (en) 2003-11-11
EP1503983A1 (en) 2005-02-09
PT1503983E (pt) 2007-07-31
CA2485428A1 (en) 2003-11-20
JP2005525420A (ja) 2005-08-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU