EA200401209A1 - Способ получения стерильной суспензии частиц кортикостероида для введения путем ингаляции - Google Patents

Способ получения стерильной суспензии частиц кортикостероида для введения путем ингаляции

Info

Publication number
EA200401209A1
EA200401209A1 EA200401209A EA200401209A EA200401209A1 EA 200401209 A1 EA200401209 A1 EA 200401209A1 EA 200401209 A EA200401209 A EA 200401209A EA 200401209 A EA200401209 A EA 200401209A EA 200401209 A1 EA200401209 A1 EA 200401209A1
Authority
EA
Eurasian Patent Office
Prior art keywords
corticosteroid
inhalation
particles
introduction
sterile suspension
Prior art date
Application number
EA200401209A
Other languages
English (en)
Other versions
EA007629B1 (ru
Inventor
Барбара Самбуко
Даниэле Пирротта
Original Assignee
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. filed Critical КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.
Publication of EA200401209A1 publication Critical patent/EA200401209A1/ru
Publication of EA007629B1 publication Critical patent/EA007629B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Описан способ получения водных суспензий стерильных тонкоизмельчённых частиц лекарства, в особенности кортикостероида, для введения путем ингаляции, который позволяет получать гомогенные дисперсии частиц, отличающихся оптимальным размером и распределением по размерам. Способ осуществляют, используя турбоэмульсификатор, снабжённый мощной турбиной и связанный с загрузочной воронкой.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401209A 2002-04-17 2003-04-15 Способ получения стерильной суспензии частиц кортикостероида для введения путем ингаляции EA007629B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002MI000808A ITMI20020808A1 (it) 2002-04-17 2002-04-17 Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione
PCT/EP2003/003916 WO2003086347A1 (en) 2002-04-17 2003-04-15 Process for preparation of a sterile suspension of corticosteroid particles for the administration by inhalation

Publications (2)

Publication Number Publication Date
EA200401209A1 true EA200401209A1 (ru) 2005-10-27
EA007629B1 EA007629B1 (ru) 2006-12-29

Family

ID=11449718

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401209A EA007629B1 (ru) 2002-04-17 2003-04-15 Способ получения стерильной суспензии частиц кортикостероида для введения путем ингаляции

Country Status (25)

Country Link
US (1) US7541021B2 (ru)
EP (1) EP1494647B1 (ru)
CN (1) CN1292733C (ru)
AR (1) AR039317A1 (ru)
AT (1) ATE338539T1 (ru)
AU (1) AU2003227627A1 (ru)
BR (1) BRPI0304821B8 (ru)
CA (1) CA2481520C (ru)
CY (1) CY1105800T1 (ru)
DE (1) DE60308164T2 (ru)
DK (1) DK1494647T3 (ru)
EA (1) EA007629B1 (ru)
ES (1) ES2272987T3 (ru)
HK (1) HK1079986B (ru)
HR (1) HRP20040964A2 (ru)
IT (1) ITMI20020808A1 (ru)
MA (1) MA27194A1 (ru)
MX (1) MXPA04010117A (ru)
PE (1) PE20030948A1 (ru)
PL (1) PL207863B1 (ru)
PT (1) PT1494647E (ru)
SI (1) SI1494647T1 (ru)
UA (1) UA79453C2 (ru)
WO (1) WO2003086347A1 (ru)
ZA (1) ZA200408319B (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4755495B2 (ja) * 2002-12-12 2011-08-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 組合せ医薬品
PT1670482E (pt) * 2003-09-16 2014-03-12 Takeda Gmbh Utilização de ciclesonida para o tratamento de doenças respiratórias
JP4836797B2 (ja) 2003-10-23 2011-12-14 大塚製薬株式会社 放出制御性無菌注射アリピプラゾール製剤および方法
PE20050941A1 (es) * 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
US20070020299A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US20070020298A1 (en) * 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid
AU2005235384B2 (en) * 2004-04-20 2010-09-09 Covis Pharma B.V. Use of ciclesonide for the treatment of respiratory diseases in a smoking patient
GB0425266D0 (en) 2004-11-16 2004-12-15 Norton Healthcare Ltd Pharmaceutical manufacturing process
ES2388287T3 (es) 2005-01-20 2012-10-11 Eratech S.R.L. Procedimiento para la preparación de suspensiones concentradas de fármacos y kit correspondiente
JP2009508859A (ja) * 2005-09-15 2009-03-05 エラン ファーマ インターナショナル リミテッド ナノ粒子アリピプラゾール製剤
US20070099883A1 (en) * 2005-10-07 2007-05-03 Cheryl Lynn Calis Anhydrous mometasone furoate formulation
WO2007095341A2 (en) * 2006-02-15 2007-08-23 Tika Läkemedel Ab Sterilization of corticosteroids with reduced mass loss
EP2170348B1 (en) * 2007-06-22 2016-08-10 Dompé farmaceutici s.p.a. Effervescent tablets for inhalatory use
DK2170279T3 (en) * 2007-07-31 2018-03-12 Otsuka Pharma Co Ltd PROCEDURES FOR PREPARING AN ARIPIPRAZOL SUSPENSION AND A FREEZER DRIED FORMULATION
CN102475708A (zh) * 2010-11-23 2012-05-30 天津金耀集团有限公司 丙酸氟替卡松和含辅料的水构成的治疗皮肤病的分离式水混悬剂药物
CN102657659A (zh) * 2010-11-23 2012-09-12 天津金耀集团有限公司 皮肤用含有辅料的丙酸氟替卡松与含有辅料的水的透皮吸收药物
RU2611665C2 (ru) 2011-05-03 2017-02-28 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Улучшенный состав суспензии кортикостероида для ингаляционного введения
CN103505412A (zh) * 2012-06-26 2014-01-15 上海臣邦医药科技有限公司 一种吸入用丙酸氟替卡松混悬液的制备方法
WO2022098321A1 (en) * 2020-11-09 2022-05-12 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of sterilised suspensions for the administration by inhalation
WO2022231533A1 (en) * 2021-04-29 2022-11-03 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of sterilized suspensions for the inhalation by nebulization
WO2022231531A1 (en) * 2021-04-29 2022-11-03 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of sterilized suspensions for the inhalation by nebulization
WO2023022672A2 (en) * 2021-08-18 2023-02-23 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Process for the preparation of homogeneous suspensions for the inhalation by nebulization

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1303692B1 (it) 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
ITMI20022674A1 (it) * 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.

Also Published As

Publication number Publication date
WO2003086347A1 (en) 2003-10-23
ES2272987T3 (es) 2007-05-01
AR039317A1 (es) 2005-02-16
DE60308164D1 (de) 2006-10-19
PL373331A1 (en) 2005-08-22
US7541021B2 (en) 2009-06-02
PT1494647E (pt) 2007-01-31
HRP20040964A2 (en) 2005-02-28
US20050175546A1 (en) 2005-08-11
PL207863B1 (pl) 2011-02-28
BRPI0304821B1 (pt) 2018-11-06
CN1292733C (zh) 2007-01-03
CY1105800T1 (el) 2011-02-02
HK1079986B (zh) 2007-05-11
DK1494647T3 (da) 2007-01-15
UA79453C2 (en) 2007-06-25
MXPA04010117A (es) 2004-12-13
SI1494647T1 (sl) 2007-02-28
EP1494647B1 (en) 2006-09-06
DE60308164T2 (de) 2007-08-09
ITMI20020808A1 (it) 2003-10-17
ITMI20020808A0 (it) 2002-04-17
ATE338539T1 (de) 2006-09-15
ZA200408319B (en) 2006-03-29
HK1079986A1 (en) 2006-04-21
CN1652748A (zh) 2005-08-10
EA007629B1 (ru) 2006-12-29
CA2481520C (en) 2011-02-22
EP1494647A1 (en) 2005-01-12
BRPI0304821B8 (pt) 2021-05-25
PE20030948A1 (es) 2004-01-19
AU2003227627A1 (en) 2003-10-27
BR0304821A (pt) 2004-06-15
CA2481520A1 (en) 2003-10-23
MA27194A1 (fr) 2005-01-03

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