EA200300987A1 - Мутанты интерлейкина-18, их продуцирование и применение - Google Patents

Мутанты интерлейкина-18, их продуцирование и применение

Info

Publication number
EA200300987A1
EA200300987A1 EA200300987A EA200300987A EA200300987A1 EA 200300987 A1 EA200300987 A1 EA 200300987A1 EA 200300987 A EA200300987 A EA 200300987A EA 200300987 A EA200300987 A EA 200300987A EA 200300987 A1 EA200300987 A1 EA 200300987A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mutants
interleukin
production
application
molecule
Prior art date
Application number
EA200300987A
Other languages
English (en)
Other versions
EA005769B1 (ru
Inventor
Чарльз Динарелло
Соо-Хиун Ким
Original Assignee
Арес Трейдинг С. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Арес Трейдинг С. А. filed Critical Арес Трейдинг С. А.
Publication of EA200300987A1 publication Critical patent/EA200300987A1/ru
Publication of EA005769B1 publication Critical patent/EA005769B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к мутантам IL-18, которые обладают более низкой аффинностью к IL-18BP, чем молекула IL-18 дикого типа.
EA200300987A 2001-03-08 2002-03-08 Мутанты интерлейкина-18, их продуцирование и применение EA005769B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27432701P 2001-03-08 2001-03-08
PCT/IB2002/002344 WO2002101049A2 (en) 2001-03-08 2002-03-08 Interleukin-18 mutants, their production and use

Publications (2)

Publication Number Publication Date
EA200300987A1 true EA200300987A1 (ru) 2004-02-26
EA005769B1 EA005769B1 (ru) 2005-06-30

Family

ID=23047735

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300987A EA005769B1 (ru) 2001-03-08 2002-03-08 Мутанты интерлейкина-18, их продуцирование и применение

Country Status (19)

Country Link
US (2) US7524488B2 (ru)
EP (1) EP1392830B1 (ru)
JP (1) JP2004530432A (ru)
KR (1) KR100862136B1 (ru)
CN (1) CN100503829C (ru)
AT (1) ATE315647T1 (ru)
AU (1) AU2002324249B2 (ru)
BR (1) BRPI0207933B8 (ru)
CA (1) CA2438851C (ru)
DE (1) DE60208692T2 (ru)
DK (1) DK1392830T3 (ru)
EA (1) EA005769B1 (ru)
ES (1) ES2251610T3 (ru)
HK (1) HK1084151A1 (ru)
IL (2) IL157800A0 (ru)
MX (1) MXPA03008110A (ru)
SI (1) SI1392830T1 (ru)
UA (1) UA79235C2 (ru)
WO (1) WO2002101049A2 (ru)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
EP1925626A1 (en) * 2003-07-21 2008-05-28 Transgene S.A. Novel multifunctional cytokines
WO2005049649A1 (en) * 2003-11-05 2005-06-02 Ares Trading S.A. Process for the purification of il-18 binding protein
US7557084B2 (en) * 2004-03-31 2009-07-07 Regeneron Pharmaceuticals, Inc. IL-18 specific polypeptides and therapeutic uses thereof
ES2370417T3 (es) 2005-06-03 2011-12-15 Ares Trading S.A. Producción de una proteína de unión a il-18 recombinante.
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
CN101177454B (zh) * 2007-05-09 2010-09-22 郑骏年 Il-18突变体多肽及制备及用途
WO2012078936A2 (en) * 2010-12-10 2012-06-14 Glaxosmithkline Llc Methods to produce a purified peptide chain fraction
BR112020004389A2 (pt) * 2017-09-06 2020-09-08 Yale University composição, e, método para tratar ou prevenir uma doença ou distúrbio em um indivíduo em necessidade do mesmo.
JP2021170968A (ja) * 2020-04-22 2021-11-01 国立大学法人 長崎大学 マウスｉｌ−１８の製造方法及びそのための組換えｄｎａ
AU2021327861A1 (en) * 2020-08-19 2023-05-04 Bright Peak Therapeutics Ag Modified il-18 polypeptides and uses thereof
IL302517A (en) 2020-11-02 2023-07-01 Simcha Il 18 Inc Variants of interleukin-18 and methods of use
US20240150421A1 (en) * 2021-02-10 2024-05-09 Nagasaki University Novel human interleukin-18 variant and use thereof
US20230146665A1 (en) 2021-07-27 2023-05-11 Xencor, Inc. Il-18-fc fusion proteins
JP2023024168A (ja) 2021-08-06 2023-02-16 国立大学法人 長崎大学 がんの治療剤
WO2023056193A2 (en) * 2021-09-29 2023-04-06 Chimera Bioengineering, Inc. Il-18 variants and uses thereof
WO2023118497A1 (en) * 2021-12-22 2023-06-29 Pieris Pharmaceuticals Gmbh Novel il-18 variants
US20230357342A1 (en) * 2022-02-23 2023-11-09 Bright Peak Therapeutics Ag Modified il-18 polypeptides
WO2023161854A1 (en) * 2022-02-23 2023-08-31 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof
US20240116997A1 (en) 2022-02-23 2024-04-11 Bright Peak Therapeutics Ag Activatable il-18 polypeptides
WO2024044780A1 (en) * 2022-08-26 2024-02-29 Sutro Biopharma, Inc. Interleukin-18 variants and uses thereof
WO2024102693A2 (en) 2022-11-07 2024-05-16 Xencor, Inc. Il-18-fc fusion proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4024366B2 (ja) * 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド
TWI227136B (en) * 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
IL129427A0 (en) 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules

Also Published As

Publication number Publication date
HK1084151A1 (en) 2006-07-21
BRPI0207933B8 (pt) 2021-05-25
WO2002101049A2 (en) 2002-12-19
DE60208692D1 (de) 2006-04-06
DE60208692T2 (de) 2006-07-13
CA2438851A1 (en) 2002-12-19
IL157800A0 (en) 2004-03-28
WO2002101049A3 (en) 2003-12-18
US20090286855A1 (en) 2009-11-19
DK1392830T3 (da) 2006-05-08
KR100862136B1 (ko) 2008-10-09
EP1392830A2 (en) 2004-03-03
CN1764723A (zh) 2006-04-26
CA2438851C (en) 2011-07-26
MXPA03008110A (es) 2003-12-12
EA005769B1 (ru) 2005-06-30
KR20030088448A (ko) 2003-11-19
AU2002324249B2 (en) 2007-04-05
UA79235C2 (en) 2007-06-11
US7524488B2 (en) 2009-04-28
SI1392830T1 (sl) 2006-06-30
ES2251610T3 (es) 2006-05-01
BRPI0207933B1 (pt) 2020-11-24
BR0207933A (pt) 2004-03-02
US20020169291A1 (en) 2002-11-14
US7875709B2 (en) 2011-01-25
EP1392830B1 (en) 2006-01-11
IL157800A (en) 2009-08-03
CN100503829C (zh) 2009-06-24
ATE315647T1 (de) 2006-02-15
JP2004530432A (ja) 2004-10-07

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU