EA200200470A1 - Новые производные тиазолидиндиона в качестве противодиабетических средств - Google Patents

Новые производные тиазолидиндиона в качестве противодиабетических средств

Info

Publication number
EA200200470A1
EA200200470A1 EA200200470A EA200200470A EA200200470A1 EA 200200470 A1 EA200200470 A1 EA 200200470A1 EA 200200470 A EA200200470 A EA 200200470A EA 200200470 A EA200200470 A EA 200200470A EA 200200470 A1 EA200200470 A1 EA 200200470A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tiazolidindion
diabetic
derivatives
new
compounds
Prior art date
Application number
EA200200470A
Other languages
English (en)
Other versions
EA004301B1 (ru
Inventor
Марисабель Моурелье Мансини
Хуан Карлос Дель Кастильо Нието
Элизабет Де Рамон Амат
Original Assignee
Вита-Инвест, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вита-Инвест, С.А. filed Critical Вита-Инвест, С.А.
Publication of EA200200470A1 publication Critical patent/EA200200470A1/ru
Publication of EA004301B1 publication Critical patent/EA004301B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Изобретение относится к соединениям общей формулы (I), к их возможным фармацевтически приемлемым солям и таутомерным формам. Изобретение также относится к способу получения данных соединений и их применению в качестве противодиабетических и гипогликемических средств как таковых или вместе с другими противодиабетическими агентами, как например, сульфонилмочевинами или бигуанидинами, а также их применению для лечения осложнений, связанных с резистентностью к инсулину, как например гипертензии, гиперурикемии или других сердечно-сосудистых, метаболических и эндокринных состояний или других нарушений, связанных с диабетом.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200470A 1999-11-18 2000-11-15 Новые производные тиазолидиндиона в качестве противодиабетических средств EA004301B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009902533A ES2156574B1 (es) 1999-11-18 1999-11-18 Nuevos derivados de tiazolidindiona como agentes antidiabeticos
PCT/ES2000/000432 WO2001036416A1 (es) 1999-11-18 2000-11-15 Nuevos derivados de tiazolidindiona como agentes antidiabeticos

Publications (2)

Publication Number Publication Date
EA200200470A1 true EA200200470A1 (ru) 2002-10-31
EA004301B1 EA004301B1 (ru) 2004-02-26

Family

ID=8310628

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200470A EA004301B1 (ru) 1999-11-18 2000-11-15 Новые производные тиазолидиндиона в качестве противодиабетических средств

Country Status (37)

Country Link
US (1) US7001910B1 (ru)
EP (1) EP1231211B1 (ru)
JP (1) JP2003514817A (ru)
KR (1) KR100518110B1 (ru)
CN (1) CN1159314C (ru)
AP (1) AP1330A (ru)
AR (1) AR031080A1 (ru)
AT (1) ATE241622T1 (ru)
AU (1) AU770045B2 (ru)
BG (1) BG106699A (ru)
BR (1) BR0015613A (ru)
CA (1) CA2391913A1 (ru)
CO (1) CO5261560A1 (ru)
CR (1) CR6640A (ru)
CZ (1) CZ20021654A3 (ru)
DE (1) DE60003072T2 (ru)
DK (1) DK1231211T3 (ru)
EA (1) EA004301B1 (ru)
EE (1) EE200200254A (ru)
ES (2) ES2156574B1 (ru)
GE (1) GEP20043240B (ru)
HR (1) HRP20020426A2 (ru)
HU (1) HUP0203478A2 (ru)
IL (1) IL149634A0 (ru)
IS (1) IS2014B (ru)
MA (1) MA26844A1 (ru)
MX (1) MXPA02005011A (ru)
NO (2) NO20022336L (ru)
NZ (1) NZ519264A (ru)
OA (1) OA12089A (ru)
PE (1) PE20010858A1 (ru)
PL (1) PL354877A1 (ru)
PT (1) PT1231211E (ru)
SK (1) SK6752002A3 (ru)
WO (1) WO2001036416A1 (ru)
YU (1) YU40202A (ru)
ZA (1) ZA200203906B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2174748B1 (es) * 2001-01-31 2003-09-16 Vita Lab Nueva sal de tiazolidindiona y sus polimorfos como agentes antidiabeticos y procedimiento para la obtencion de los mismos.
KR100450700B1 (ko) * 2002-03-22 2004-10-01 주식회사종근당 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물
US7713983B2 (en) 2003-03-03 2010-05-11 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
CL2004000409A1 (es) 2003-03-03 2005-01-07 Vertex Pharma Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
US20050014732A1 (en) * 2003-03-14 2005-01-20 Pharmacia Corporation Combination of an aldosterone receptor antagonist and an anti-diabetic agent
US7928107B2 (en) 2004-09-02 2011-04-19 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
US8283354B2 (en) 2004-09-02 2012-10-09 Vertex Pharmaceuticals Incorporated Quinazolines useful as modulators of ion channels
CZ297347B6 (cs) * 2004-09-21 2006-11-15 Zentiva, A. S. Zpusob prípravy rosiglitazonu
JP5546372B2 (ja) * 2010-06-30 2014-07-09 積水メディカル株式会社 ベンジルヒダントイン化合物の製造法
WO2016184895A1 (en) 2015-05-18 2016-11-24 Institut National De La Sante Et De La Recherche Medicale (Inserm) Means for detecting or measuring a biological activity of a botulinum toxin
US10689374B1 (en) 2019-07-12 2020-06-23 United Arab Emirates University Pyrimidine-thiazolidinone derivatives
US10702525B1 (en) 2019-09-04 2020-07-07 United Arab Emirates University Pyrimidine derivatives as anti-diabetic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240698A1 (es) * 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
ES2137915T3 (es) * 1987-09-04 2000-01-01 Beecham Group Plc Derivados de tiazolidindiona sustituida.
GB9023583D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
PT1231211E (pt) 2003-09-30
IS2014B (is) 2005-06-15
CN1402724A (zh) 2003-03-12
ATE241622T1 (de) 2003-06-15
CZ20021654A3 (cs) 2002-09-11
BR0015613A (pt) 2002-07-23
OA12089A (en) 2006-05-04
MA26844A1 (fr) 2004-12-20
KR100518110B1 (ko) 2005-10-04
MXPA02005011A (es) 2003-10-14
SK6752002A3 (en) 2002-09-10
WO2001036416A1 (es) 2001-05-25
NO20022379D0 (no) 2002-05-16
ES2156574A1 (es) 2001-06-16
ES2156574B1 (es) 2002-02-01
BG106699A (bg) 2003-02-28
YU40202A (sh) 2006-01-16
AR031080A1 (es) 2003-09-10
HRP20020426A2 (en) 2004-02-29
ZA200203906B (en) 2004-03-26
DE60003072T2 (de) 2004-04-01
AU770045B2 (en) 2004-02-12
EP1231211A1 (en) 2002-08-14
KR20020079737A (ko) 2002-10-19
GEP20043240B (en) 2004-05-25
EA004301B1 (ru) 2004-02-26
IS6386A (is) 2002-05-15
AP1330A (en) 2004-11-25
DK1231211T3 (da) 2003-10-27
AU1281501A (en) 2001-05-30
US7001910B1 (en) 2006-02-21
CO5261560A1 (es) 2003-03-31
PL354877A1 (en) 2004-03-08
NZ519264A (en) 2003-10-31
DE60003072D1 (de) 2003-07-03
CR6640A (es) 2004-03-05
JP2003514817A (ja) 2003-04-22
EE200200254A (et) 2003-06-16
CA2391913A1 (en) 2001-05-25
HUP0203478A2 (hu) 2003-02-28
ES2199878T3 (es) 2004-03-01
IL149634A0 (en) 2002-11-10
NO20022336D0 (no) 2002-05-15
NO20022336L (no) 2002-07-09
CN1159314C (zh) 2004-07-28
AP2002002512A0 (en) 2002-06-30
EP1231211B1 (en) 2003-05-28
PE20010858A1 (es) 2001-08-22

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Legal Events

Date Code Title Description
PD1A Registration of transfer to a eurasian application by order of succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU