EA200100106A1 - Замещенные фениламидины с антитромботическим действием - Google Patents

Замещенные фениламидины с антитромботическим действием

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Publication number
EA200100106A1
EA200100106A1 EA200100106A EA200100106A EA200100106A1 EA 200100106 A1 EA200100106 A1 EA 200100106A1 EA 200100106 A EA200100106 A EA 200100106A EA 200100106 A EA200100106 A EA 200100106A EA 200100106 A1 EA200100106 A1 EA 200100106A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
phenylamidines
describes
compounds
thrombotic action
Prior art date
Application number
EA200100106A
Other languages
English (en)
Inventor
Франк Химмельсбах
Бриан Гут
Ханс-Дитер Шуберт
Original Assignee
Бёрингер Ингельхайм Фарма Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Фарма Кг filed Critical Бёрингер Ингельхайм Фарма Кг
Publication of EA200100106A1 publication Critical patent/EA200100106A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В заявке описаны фениламидины общей формулыв которой Rи Rимеют значения, указанные в п.1, их таутомеры, стереоизомеры, включая их смеси, и соли, в частности их физиологически приемлемые соли с неорганическими или органическими кислотами или с основаниями. Предлагаемые соединения обладают ценными фармакологическими свойствами, преимущественно антитромботическим действием. В заявке описаны также лекарственные средства, содержащие эти соединения, их применение и способ их получения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100106A 1998-07-23 1999-07-20 Замещенные фениламидины с антитромботическим действием EA200100106A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833105A DE19833105A1 (de) 1998-07-23 1998-07-23 Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PCT/EP1999/005161 WO2000005207A1 (de) 1998-07-23 1999-07-20 Substituierte phenylamidine mit antithrombotischer wirkung

Publications (1)

Publication Number Publication Date
EA200100106A1 true EA200100106A1 (ru) 2001-08-27

Family

ID=7875009

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100106A EA200100106A1 (ru) 1998-07-23 1999-07-20 Замещенные фениламидины с антитромботическим действием

Country Status (30)

Country Link
EP (1) EP1102746B1 (ru)
JP (1) JP3629208B2 (ru)
KR (1) KR20010072046A (ru)
CN (1) CN1310708A (ru)
AR (1) AR019462A1 (ru)
AT (1) ATE240297T1 (ru)
AU (1) AU5285399A (ru)
BG (1) BG105159A (ru)
BR (1) BR9912321A (ru)
CA (1) CA2337413A1 (ru)
CO (1) CO5080745A1 (ru)
DE (2) DE19833105A1 (ru)
DK (1) DK1102746T3 (ru)
EA (1) EA200100106A1 (ru)
EE (1) EE200100048A (ru)
ES (1) ES2199587T3 (ru)
HK (1) HK1038750A1 (ru)
HU (1) HUP0103327A3 (ru)
ID (1) ID27205A (ru)
IL (1) IL140774A0 (ru)
NO (1) NO20010354L (ru)
PL (1) PL345624A1 (ru)
PT (1) PT1102746E (ru)
SK (1) SK1052001A3 (ru)
TR (1) TR200100182T2 (ru)
TW (1) TW460461B (ru)
UY (1) UY25621A1 (ru)
WO (1) WO2000005207A1 (ru)
YU (1) YU3701A (ru)
ZA (1) ZA200100363B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10002510A1 (de) 2000-01-21 2001-07-26 Boehringer Ingelheim Pharma Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US8399678B2 (en) * 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
EP2522662A1 (en) * 2011-05-11 2012-11-14 Medichem, S.A. Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers
CN105330568B (zh) * 2015-11-27 2017-05-10 山东省医学科学院药物研究所 一种对氨基苯甲脒盐酸盐的制备方法
CN105732433A (zh) * 2016-04-13 2016-07-06 山东新华制药股份有限公司 达比加群酯中间体缩合物的精制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016947A1 (fr) * 1994-12-01 1996-06-06 Toyama Chemical Co., Ltd. Nouveau derive de 2,3-dicetopiperazine ou sel de celui-ci
DE19515500A1 (de) * 1995-04-27 1996-10-31 Thomae Gmbh Dr K Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
NO20010354D0 (no) 2001-01-22
HUP0103327A3 (en) 2003-11-28
ATE240297T1 (de) 2003-05-15
EP1102746B1 (de) 2003-05-14
BR9912321A (pt) 2001-04-24
ID27205A (id) 2001-03-08
PL345624A1 (en) 2002-01-02
DE19833105A1 (de) 2000-01-27
YU3701A (sh) 2003-01-31
CO5080745A1 (es) 2001-09-25
AR019462A1 (es) 2002-02-20
HK1038750A1 (zh) 2002-03-28
JP3629208B2 (ja) 2005-03-16
BG105159A (bg) 2001-07-31
ZA200100363B (en) 2001-07-18
IL140774A0 (en) 2002-02-10
EP1102746A1 (de) 2001-05-30
CN1310708A (zh) 2001-08-29
PT1102746E (pt) 2003-10-31
UY25621A1 (es) 2001-12-28
TR200100182T2 (tr) 2001-07-23
ES2199587T3 (es) 2004-02-16
CA2337413A1 (en) 2000-02-03
WO2000005207A1 (de) 2000-02-03
HUP0103327A2 (hu) 2002-01-28
AU5285399A (en) 2000-02-14
SK1052001A3 (en) 2001-08-06
TW460461B (en) 2001-10-21
EE200100048A (et) 2002-06-17
DE59905568D1 (de) 2003-06-18
NO20010354L (no) 2001-01-22
KR20010072046A (ko) 2001-07-31
DK1102746T3 (da) 2003-09-08
JP2002521363A (ja) 2002-07-16

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