HUP0103327A2 - Trombózis-ellenes hatású szubsztituált fenil-amidinek - Google Patents
Trombózis-ellenes hatású szubsztituált fenil-amidinekInfo
- Publication number
- HUP0103327A2 HUP0103327A2 HU0103327A HUP0103327A HUP0103327A2 HU P0103327 A2 HUP0103327 A2 HU P0103327A2 HU 0103327 A HU0103327 A HU 0103327A HU P0103327 A HUP0103327 A HU P0103327A HU P0103327 A2 HUP0103327 A2 HU P0103327A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- cycloalkyl
- alkyl
- compounds
- Prior art date
Links
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 230000008619 cell matrix interaction Effects 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
- C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgyát az általános képletű fenil-amidinek - ahol R6alkoxi-karbonilcsoport vagy fenil-alkoxi-karbonilcsoport, R7hidrogénatom, alkil-, cikloalkil-, fenil-alkilcsoport vagy R8-CO-OCHR9általános képletű csoport, amelyben R8 alkil-, alkoxi-, cikloalkil-vagy cikloalkoxicsoport, R9 hidrogénatom vagy alkilcsoport - éstautomereik, sztereoizomereik és szervetlen vagy szerves savakkal vagybázisokkal alkotott, fiziológiailag elfogadható sóik, legalább egyilyen vegyületet vagy több inert hordozóval és/vagy hígítószerrelegyütt tartalmazó gyógyszerek, ilyen vegyületek alkalmazása olyanbetegségek leküzdésére vagy megelőzésére alkalmas gyógyszerelőállítására, amelyeknél kisebb vagy nagyobb sejtaggregátumokkeletkeznek vagy sejt-mátrix-kölcsönhatások szerepet játszanak,valamint az (I) általános képletű vegyületek előállítására szolgálóeljárás képezik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833105A DE19833105A1 (de) | 1998-07-23 | 1998-07-23 | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| PCT/EP1999/005161 WO2000005207A1 (de) | 1998-07-23 | 1999-07-20 | Substituierte phenylamidine mit antithrombotischer wirkung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0103327A2 true HUP0103327A2 (hu) | 2002-01-28 |
| HUP0103327A3 HUP0103327A3 (en) | 2003-11-28 |
Family
ID=7875009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103327A HUP0103327A3 (en) | 1998-07-23 | 1999-07-20 | Substituted phenylamidines with antithrombotic action |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1102746B1 (hu) |
| JP (1) | JP3629208B2 (hu) |
| KR (1) | KR20010072046A (hu) |
| CN (1) | CN1310708A (hu) |
| AR (1) | AR019462A1 (hu) |
| AT (1) | ATE240297T1 (hu) |
| AU (1) | AU5285399A (hu) |
| BG (1) | BG105159A (hu) |
| BR (1) | BR9912321A (hu) |
| CA (1) | CA2337413A1 (hu) |
| CO (1) | CO5080745A1 (hu) |
| DE (2) | DE19833105A1 (hu) |
| DK (1) | DK1102746T3 (hu) |
| EA (1) | EA200100106A1 (hu) |
| EE (1) | EE200100048A (hu) |
| ES (1) | ES2199587T3 (hu) |
| HK (1) | HK1038750A1 (hu) |
| HU (1) | HUP0103327A3 (hu) |
| ID (1) | ID27205A (hu) |
| IL (1) | IL140774A0 (hu) |
| NO (1) | NO20010354D0 (hu) |
| PL (1) | PL345624A1 (hu) |
| PT (1) | PT1102746E (hu) |
| SK (1) | SK1052001A3 (hu) |
| TR (1) | TR200100182T2 (hu) |
| TW (1) | TW460461B (hu) |
| UY (1) | UY25621A1 (hu) |
| WO (1) | WO2000005207A1 (hu) |
| YU (1) | YU3701A (hu) |
| ZA (1) | ZA200100363B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10002510A1 (de) | 2000-01-21 | 2001-07-26 | Boehringer Ingelheim Pharma | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
| EP2522662A1 (en) * | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
| CN105330568B (zh) * | 2015-11-27 | 2017-05-10 | 山东省医学科学院药物研究所 | 一种对氨基苯甲脒盐酸盐的制备方法 |
| CN105732433A (zh) * | 2016-04-13 | 2016-07-06 | 山东新华制药股份有限公司 | 达比加群酯中间体缩合物的精制方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU691361B2 (en) * | 1994-12-01 | 1998-05-14 | Toyama Chemical Co. Ltd. | Novel 2,3-diketopiperazine derivative or salt thereof |
| DE19515500A1 (de) * | 1995-04-27 | 1996-10-31 | Thomae Gmbh Dr K | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
-
1998
- 1998-07-23 DE DE19833105A patent/DE19833105A1/de not_active Withdrawn
-
1999
- 1999-07-19 CO CO99045660A patent/CO5080745A1/es unknown
- 1999-07-20 DK DK99938296T patent/DK1102746T3/da active
- 1999-07-20 ID IDW20010171A patent/ID27205A/id unknown
- 1999-07-20 EP EP99938296A patent/EP1102746B1/de not_active Expired - Lifetime
- 1999-07-20 BR BR9912321-5A patent/BR9912321A/pt not_active IP Right Cessation
- 1999-07-20 SK SK105-2001A patent/SK1052001A3/sk unknown
- 1999-07-20 CN CN99808971A patent/CN1310708A/zh active Pending
- 1999-07-20 PT PT99938296T patent/PT1102746E/pt unknown
- 1999-07-20 TR TR2001/00182T patent/TR200100182T2/xx unknown
- 1999-07-20 KR KR1020017001005A patent/KR20010072046A/ko not_active Application Discontinuation
- 1999-07-20 WO PCT/EP1999/005161 patent/WO2000005207A1/de not_active Application Discontinuation
- 1999-07-20 EE EEP200100048A patent/EE200100048A/xx unknown
- 1999-07-20 AU AU52853/99A patent/AU5285399A/en not_active Abandoned
- 1999-07-20 DE DE59905568T patent/DE59905568D1/de not_active Expired - Fee Related
- 1999-07-20 YU YU3701A patent/YU3701A/sh unknown
- 1999-07-20 HU HU0103327A patent/HUP0103327A3/hu unknown
- 1999-07-20 AT AT99938296T patent/ATE240297T1/de not_active IP Right Cessation
- 1999-07-20 ES ES99938296T patent/ES2199587T3/es not_active Expired - Lifetime
- 1999-07-20 PL PL99345624A patent/PL345624A1/xx not_active Application Discontinuation
- 1999-07-20 JP JP2000561164A patent/JP3629208B2/ja not_active Expired - Fee Related
- 1999-07-20 CA CA002337413A patent/CA2337413A1/en not_active Abandoned
- 1999-07-20 IL IL14077499A patent/IL140774A0/xx unknown
- 1999-07-20 EA EA200100106A patent/EA200100106A1/ru unknown
- 1999-07-21 TW TW088112395A patent/TW460461B/zh not_active IP Right Cessation
- 1999-07-22 UY UY25621A patent/UY25621A1/es not_active Application Discontinuation
- 1999-07-23 AR ARP990103627A patent/AR019462A1/es not_active Withdrawn
-
2001
- 2001-01-12 ZA ZA200100363A patent/ZA200100363B/en unknown
- 2001-01-16 BG BG105159A patent/BG105159A/bg active Pending
- 2001-01-22 NO NO20010354A patent/NO20010354D0/no unknown
-
2002
- 2002-01-17 HK HK02100364.6A patent/HK1038750A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL140774A0 (en) | 2002-02-10 |
| DE59905568D1 (de) | 2003-06-18 |
| DK1102746T3 (da) | 2003-09-08 |
| PL345624A1 (en) | 2002-01-02 |
| ZA200100363B (en) | 2001-07-18 |
| CO5080745A1 (es) | 2001-09-25 |
| WO2000005207A1 (de) | 2000-02-03 |
| CA2337413A1 (en) | 2000-02-03 |
| ATE240297T1 (de) | 2003-05-15 |
| ES2199587T3 (es) | 2004-02-16 |
| BG105159A (bg) | 2001-07-31 |
| AU5285399A (en) | 2000-02-14 |
| BR9912321A (pt) | 2001-04-24 |
| JP3629208B2 (ja) | 2005-03-16 |
| JP2002521363A (ja) | 2002-07-16 |
| CN1310708A (zh) | 2001-08-29 |
| EP1102746A1 (de) | 2001-05-30 |
| AR019462A1 (es) | 2002-02-20 |
| EP1102746B1 (de) | 2003-05-14 |
| TR200100182T2 (tr) | 2001-07-23 |
| SK1052001A3 (en) | 2001-08-06 |
| EE200100048A (et) | 2002-06-17 |
| NO20010354L (no) | 2001-01-22 |
| YU3701A (sh) | 2003-01-31 |
| ID27205A (id) | 2001-03-08 |
| HUP0103327A3 (en) | 2003-11-28 |
| KR20010072046A (ko) | 2001-07-31 |
| NO20010354D0 (no) | 2001-01-22 |
| DE19833105A1 (de) | 2000-01-27 |
| HK1038750A1 (zh) | 2002-03-28 |
| UY25621A1 (es) | 2001-12-28 |
| TW460461B (en) | 2001-10-21 |
| PT1102746E (pt) | 2003-10-31 |
| EA200100106A1 (ru) | 2001-08-27 |
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