DK1102746T3 - Substituerede phenylamidiner med antitrombotisk virkning - Google Patents
Substituerede phenylamidiner med antitrombotisk virkningInfo
- Publication number
- DK1102746T3 DK1102746T3 DK99938296T DK99938296T DK1102746T3 DK 1102746 T3 DK1102746 T3 DK 1102746T3 DK 99938296 T DK99938296 T DK 99938296T DK 99938296 T DK99938296 T DK 99938296T DK 1102746 T3 DK1102746 T3 DK 1102746T3
- Authority
- DK
- Denmark
- Prior art keywords
- antithrombotic effect
- substituted phenylamidines
- phenylamidines
- substituted
- antithrombotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
- C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833105A DE19833105A1 (de) | 1998-07-23 | 1998-07-23 | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
PCT/EP1999/005161 WO2000005207A1 (de) | 1998-07-23 | 1999-07-20 | Substituierte phenylamidine mit antithrombotischer wirkung |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1102746T3 true DK1102746T3 (da) | 2003-09-08 |
Family
ID=7875009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99938296T DK1102746T3 (da) | 1998-07-23 | 1999-07-20 | Substituerede phenylamidiner med antitrombotisk virkning |
Country Status (30)
Country | Link |
---|---|
EP (1) | EP1102746B1 (da) |
JP (1) | JP3629208B2 (da) |
KR (1) | KR20010072046A (da) |
CN (1) | CN1310708A (da) |
AR (1) | AR019462A1 (da) |
AT (1) | ATE240297T1 (da) |
AU (1) | AU5285399A (da) |
BG (1) | BG105159A (da) |
BR (1) | BR9912321A (da) |
CA (1) | CA2337413A1 (da) |
CO (1) | CO5080745A1 (da) |
DE (2) | DE19833105A1 (da) |
DK (1) | DK1102746T3 (da) |
EA (1) | EA200100106A1 (da) |
EE (1) | EE200100048A (da) |
ES (1) | ES2199587T3 (da) |
HK (1) | HK1038750A1 (da) |
HU (1) | HUP0103327A3 (da) |
ID (1) | ID27205A (da) |
IL (1) | IL140774A0 (da) |
NO (1) | NO20010354D0 (da) |
PL (1) | PL345624A1 (da) |
PT (1) | PT1102746E (da) |
SK (1) | SK1052001A3 (da) |
TR (1) | TR200100182T2 (da) |
TW (1) | TW460461B (da) |
UY (1) | UY25621A1 (da) |
WO (1) | WO2000005207A1 (da) |
YU (1) | YU3701A (da) |
ZA (1) | ZA200100363B (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10002510A1 (de) * | 2000-01-21 | 2001-07-26 | Boehringer Ingelheim Pharma | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
EP2522662A1 (en) * | 2011-05-11 | 2012-11-14 | Medichem, S.A. | Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers |
CN105330568B (zh) * | 2015-11-27 | 2017-05-10 | 山东省医学科学院药物研究所 | 一种对氨基苯甲脒盐酸盐的制备方法 |
CN105732433A (zh) * | 2016-04-13 | 2016-07-06 | 山东新华制药股份有限公司 | 达比加群酯中间体缩合物的精制方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1170409A (zh) * | 1994-12-01 | 1998-01-14 | 富山化学工业株式会社 | 新的2,3-二氧代哌嗪衍生物及其盐 |
DE19515500A1 (de) * | 1995-04-27 | 1996-10-31 | Thomae Gmbh Dr K | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
-
1998
- 1998-07-23 DE DE19833105A patent/DE19833105A1/de not_active Withdrawn
-
1999
- 1999-07-19 CO CO99045660A patent/CO5080745A1/es unknown
- 1999-07-20 AU AU52853/99A patent/AU5285399A/en not_active Abandoned
- 1999-07-20 EE EEP200100048A patent/EE200100048A/xx unknown
- 1999-07-20 KR KR1020017001005A patent/KR20010072046A/ko not_active Application Discontinuation
- 1999-07-20 WO PCT/EP1999/005161 patent/WO2000005207A1/de not_active Application Discontinuation
- 1999-07-20 AT AT99938296T patent/ATE240297T1/de not_active IP Right Cessation
- 1999-07-20 PT PT99938296T patent/PT1102746E/pt unknown
- 1999-07-20 YU YU3701A patent/YU3701A/sh unknown
- 1999-07-20 CA CA002337413A patent/CA2337413A1/en not_active Abandoned
- 1999-07-20 DK DK99938296T patent/DK1102746T3/da active
- 1999-07-20 BR BR9912321-5A patent/BR9912321A/pt not_active IP Right Cessation
- 1999-07-20 PL PL99345624A patent/PL345624A1/xx not_active Application Discontinuation
- 1999-07-20 ES ES99938296T patent/ES2199587T3/es not_active Expired - Lifetime
- 1999-07-20 DE DE59905568T patent/DE59905568D1/de not_active Expired - Fee Related
- 1999-07-20 CN CN99808971A patent/CN1310708A/zh active Pending
- 1999-07-20 TR TR2001/00182T patent/TR200100182T2/xx unknown
- 1999-07-20 ID IDW20010171A patent/ID27205A/id unknown
- 1999-07-20 EP EP99938296A patent/EP1102746B1/de not_active Expired - Lifetime
- 1999-07-20 IL IL14077499A patent/IL140774A0/xx unknown
- 1999-07-20 HU HU0103327A patent/HUP0103327A3/hu unknown
- 1999-07-20 EA EA200100106A patent/EA200100106A1/ru unknown
- 1999-07-20 SK SK105-2001A patent/SK1052001A3/sk unknown
- 1999-07-20 JP JP2000561164A patent/JP3629208B2/ja not_active Expired - Fee Related
- 1999-07-21 TW TW088112395A patent/TW460461B/zh not_active IP Right Cessation
- 1999-07-22 UY UY25621A patent/UY25621A1/es not_active Application Discontinuation
- 1999-07-23 AR ARP990103627A patent/AR019462A1/es not_active Withdrawn
-
2001
- 2001-01-12 ZA ZA200100363A patent/ZA200100363B/en unknown
- 2001-01-16 BG BG105159A patent/BG105159A/bg active Pending
- 2001-01-22 NO NO20010354A patent/NO20010354D0/no unknown
-
2002
- 2002-01-17 HK HK02100364.6A patent/HK1038750A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
UY25621A1 (es) | 2001-12-28 |
ES2199587T3 (es) | 2004-02-16 |
KR20010072046A (ko) | 2001-07-31 |
IL140774A0 (en) | 2002-02-10 |
EP1102746A1 (de) | 2001-05-30 |
SK1052001A3 (en) | 2001-08-06 |
AR019462A1 (es) | 2002-02-20 |
ID27205A (id) | 2001-03-08 |
NO20010354L (no) | 2001-01-22 |
EA200100106A1 (ru) | 2001-08-27 |
DE19833105A1 (de) | 2000-01-27 |
NO20010354D0 (no) | 2001-01-22 |
TW460461B (en) | 2001-10-21 |
WO2000005207A1 (de) | 2000-02-03 |
CO5080745A1 (es) | 2001-09-25 |
EE200100048A (et) | 2002-06-17 |
CA2337413A1 (en) | 2000-02-03 |
CN1310708A (zh) | 2001-08-29 |
TR200100182T2 (tr) | 2001-07-23 |
BR9912321A (pt) | 2001-04-24 |
PL345624A1 (en) | 2002-01-02 |
JP2002521363A (ja) | 2002-07-16 |
ATE240297T1 (de) | 2003-05-15 |
PT1102746E (pt) | 2003-10-31 |
JP3629208B2 (ja) | 2005-03-16 |
HK1038750A1 (zh) | 2002-03-28 |
HUP0103327A3 (en) | 2003-11-28 |
ZA200100363B (en) | 2001-07-18 |
YU3701A (sh) | 2003-01-31 |
DE59905568D1 (de) | 2003-06-18 |
EP1102746B1 (de) | 2003-05-14 |
BG105159A (bg) | 2001-07-31 |
HUP0103327A2 (hu) | 2002-01-28 |
AU5285399A (en) | 2000-02-14 |
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