CO5080745A1 - Fenilamidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparacion - Google Patents

Fenilamidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparacion

Info

Publication number
CO5080745A1
CO5080745A1 CO99045660A CO99045660A CO5080745A1 CO 5080745 A1 CO5080745 A1 CO 5080745A1 CO 99045660 A CO99045660 A CO 99045660A CO 99045660 A CO99045660 A CO 99045660A CO 5080745 A1 CO5080745 A1 CO 5080745A1
Authority
CO
Colombia
Prior art keywords
phenylamidines
compounds
replaced
procedure
preparation
Prior art date
Application number
CO99045660A
Other languages
English (en)
Inventor
Frank Himmelsbach
Guth Braian
Hans-Dieter Schubert
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of CO5080745A1 publication Critical patent/CO5080745A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
    • C07C211/50—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Fenilamidinas de la fórmula general<EMI FILE="99045660_1" ID="1" IMF=JPEG >en la que R6 significa un grupo alquiloxi C1-18 -carbonilo o fenil-alquiloxi C1-4 -carboniloR7 significa un átomo de hidrógeno, un grupo alquilo C1-18 , cicloalquilo C4-7, fenil-alquilo C1-4 o R8 -CO-OCHR9 , en la que R8 significa un grupo alquilo C1-4, alcoxi C1-4, cicloalquilo C3-7 o cicloalcoxi C4-7 y R9 significa un átomo de hidrógeno o un grupo alquilo C1-4 , sus tautómeros, sus estereoisómeros y sus sales.
CO99045660A 1998-07-23 1999-07-19 Fenilamidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparacion CO5080745A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833105A DE19833105A1 (de) 1998-07-23 1998-07-23 Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
CO5080745A1 true CO5080745A1 (es) 2001-09-25

Family

ID=7875009

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99045660A CO5080745A1 (es) 1998-07-23 1999-07-19 Fenilamidinas sustituidas, medicamentos que contienen estos compuestos y procedimiento para su preparacion

Country Status (30)

Country Link
EP (1) EP1102746B1 (es)
JP (1) JP3629208B2 (es)
KR (1) KR20010072046A (es)
CN (1) CN1310708A (es)
AR (1) AR019462A1 (es)
AT (1) ATE240297T1 (es)
AU (1) AU5285399A (es)
BG (1) BG105159A (es)
BR (1) BR9912321A (es)
CA (1) CA2337413A1 (es)
CO (1) CO5080745A1 (es)
DE (2) DE19833105A1 (es)
DK (1) DK1102746T3 (es)
EA (1) EA200100106A1 (es)
EE (1) EE200100048A (es)
ES (1) ES2199587T3 (es)
HK (1) HK1038750A1 (es)
HU (1) HUP0103327A3 (es)
ID (1) ID27205A (es)
IL (1) IL140774A0 (es)
NO (1) NO20010354D0 (es)
PL (1) PL345624A1 (es)
PT (1) PT1102746E (es)
SK (1) SK1052001A3 (es)
TR (1) TR200100182T2 (es)
TW (1) TW460461B (es)
UY (1) UY25621A1 (es)
WO (1) WO2000005207A1 (es)
YU (1) YU3701A (es)
ZA (1) ZA200100363B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10002510A1 (de) * 2000-01-21 2001-07-26 Boehringer Ingelheim Pharma Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US8399678B2 (en) * 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
EP2522662A1 (en) 2011-05-11 2012-11-14 Medichem, S.A. Dabigatran etexilate and related substances, processes and compositions, and use of the substances as reference standards and markers
CN105330568B (zh) * 2015-11-27 2017-05-10 山东省医学科学院药物研究所 一种对氨基苯甲脒盐酸盐的制备方法
CN105732433A (zh) * 2016-04-13 2016-07-06 山东新华制药股份有限公司 达比加群酯中间体缩合物的精制方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877174A (en) * 1994-12-01 1999-03-02 Toyama Chemical Co., Ltd. 2,3-diketopiperazine derivatives or their salts
DE19515500A1 (de) * 1995-04-27 1996-10-31 Thomae Gmbh Dr K Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
PL345624A1 (en) 2002-01-02
AU5285399A (en) 2000-02-14
ES2199587T3 (es) 2004-02-16
UY25621A1 (es) 2001-12-28
HUP0103327A2 (hu) 2002-01-28
IL140774A0 (en) 2002-02-10
ID27205A (id) 2001-03-08
NO20010354L (no) 2001-01-22
EP1102746A1 (de) 2001-05-30
EE200100048A (et) 2002-06-17
HK1038750A1 (zh) 2002-03-28
TR200100182T2 (tr) 2001-07-23
WO2000005207A1 (de) 2000-02-03
DE59905568D1 (de) 2003-06-18
ATE240297T1 (de) 2003-05-15
CN1310708A (zh) 2001-08-29
DE19833105A1 (de) 2000-01-27
YU3701A (sh) 2003-01-31
PT1102746E (pt) 2003-10-31
TW460461B (en) 2001-10-21
NO20010354D0 (no) 2001-01-22
JP3629208B2 (ja) 2005-03-16
HUP0103327A3 (en) 2003-11-28
ZA200100363B (en) 2001-07-18
EA200100106A1 (ru) 2001-08-27
JP2002521363A (ja) 2002-07-16
EP1102746B1 (de) 2003-05-14
SK1052001A3 (en) 2001-08-06
BG105159A (bg) 2001-07-31
BR9912321A (pt) 2001-04-24
CA2337413A1 (en) 2000-02-03
DK1102746T3 (da) 2003-09-08
AR019462A1 (es) 2002-02-20
KR20010072046A (ko) 2001-07-31

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