EA200000922A1 - Производные аминоантрациклинона и их применение в лечении амилоидоза - Google Patents
Производные аминоантрациклинона и их применение в лечении амилоидозаInfo
- Publication number
- EA200000922A1 EA200000922A1 EA200000922A EA200000922A EA200000922A1 EA 200000922 A1 EA200000922 A1 EA 200000922A1 EA 200000922 A EA200000922 A EA 200000922A EA 200000922 A EA200000922 A EA 200000922A EA 200000922 A1 EA200000922 A1 EA 200000922A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrogen
- hydroxy
- amyloidosis
- formula
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Соединение формулы (1), в которой Rпредставляет собой водород, гидрокси, группу формулы OR, в которой Rозначает C-C-алкил, C-C-алкенил; Rпредставляет собой водород, гидрокси, диэтиламин, пиперидин, тетрагидропиридин или морфолин, и либо R, взятый в отдельности, означает водород или гидрокси и Rи R, взятые в отдельности, независимо означают водород, гидрокси или, взятые вместе с углеродным атомом, означают карбонильную группу; или Rи R, взятые вместе, означают группу формулы (A), в которой Rи Rпредставляют собой C-C-алкил и Rозначает водород; Rпредставляет собой водород или фенильную группу, необязательно замещенную метилом, метокси или галогеном, и его фармацевтически приемлемую соль применяют в лечении амилоидоза. Также описаны способы получения и фармацевтические композиции.Отчет о международном поиске был опубликован 1999.10.21.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805080.0A GB9805080D0 (en) | 1998-03-10 | 1998-03-10 | Amino anthracyclinone derivatives |
| PCT/EP1999/001300 WO1999046254A2 (en) | 1998-03-10 | 1999-02-25 | Amino anthracyclinone derivatives and their use in the treatment of amyloidosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000922A1 true EA200000922A1 (ru) | 2001-04-23 |
| EA003333B1 EA003333B1 (ru) | 2003-04-24 |
Family
ID=10828304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000922A EA003333B1 (ru) | 1998-03-10 | 1999-02-25 | Производные аминоантрациклинона и их применение в лечении амилоидоза |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6268362B1 (ru) |
| EP (1) | EP1062206B1 (ru) |
| JP (1) | JP2002506066A (ru) |
| KR (1) | KR100603798B1 (ru) |
| CN (1) | CN1113867C (ru) |
| AR (1) | AR019831A1 (ru) |
| AT (1) | ATE264302T1 (ru) |
| AU (1) | AU755754B2 (ru) |
| BR (1) | BR9908057A (ru) |
| CA (1) | CA2321834A1 (ru) |
| DE (1) | DE69916438D1 (ru) |
| EA (1) | EA003333B1 (ru) |
| GB (1) | GB9805080D0 (ru) |
| HU (1) | HUP0101046A3 (ru) |
| ID (1) | ID26084A (ru) |
| IL (1) | IL137677A (ru) |
| NO (1) | NO317260B1 (ru) |
| NZ (1) | NZ506945A (ru) |
| PL (1) | PL193245B1 (ru) |
| TW (1) | TW528751B (ru) |
| UA (1) | UA51838C2 (ru) |
| WO (1) | WO1999046254A2 (ru) |
| ZA (1) | ZA991839B (ru) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110264A1 (it) * | 2011-05-27 | 2012-11-28 | Univ Degli Studi Milano | Nuovi composti triciclici glicofusi, procedimento per la loro produzione e loro impiego quali ligandi dei peptidi ss amiloidi (ass). |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110289A (en) | 1993-08-06 | 1998-01-04 | Policlinico San Matteo Istitut | Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis |
| GB9416007D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9516349D0 (en) | 1995-08-09 | 1995-10-11 | Pharmacia Spa | Aza-anthracyclinone derivatives |
| GB9613433D0 (en) | 1996-06-26 | 1996-08-28 | Pharmacia Spa | Fluoro labelled anthracyclinone and anthracycline derivatives |
-
1998
- 1998-03-10 GB GBGB9805080.0A patent/GB9805080D0/en not_active Ceased
-
1999
- 1999-02-11 TW TW088102135A patent/TW528751B/zh not_active IP Right Cessation
- 1999-02-25 CN CN99803596A patent/CN1113867C/zh not_active Expired - Fee Related
- 1999-02-25 WO PCT/EP1999/001300 patent/WO1999046254A2/en not_active Application Discontinuation
- 1999-02-25 DE DE69916438T patent/DE69916438D1/de not_active Expired - Lifetime
- 1999-02-25 PL PL344086A patent/PL193245B1/pl not_active IP Right Cessation
- 1999-02-25 KR KR1020007009971A patent/KR100603798B1/ko not_active IP Right Cessation
- 1999-02-25 HU HU0101046A patent/HUP0101046A3/hu unknown
- 1999-02-25 AT AT99910304T patent/ATE264302T1/de not_active IP Right Cessation
- 1999-02-25 IL IL13767799A patent/IL137677A/xx not_active IP Right Cessation
- 1999-02-25 EA EA200000922A patent/EA003333B1/ru not_active IP Right Cessation
- 1999-02-25 CA CA002321834A patent/CA2321834A1/en not_active Abandoned
- 1999-02-25 UA UA2000105718A patent/UA51838C2/ru unknown
- 1999-02-25 JP JP2000535634A patent/JP2002506066A/ja not_active Withdrawn
- 1999-02-25 US US09/622,921 patent/US6268362B1/en not_active Expired - Fee Related
- 1999-02-25 NZ NZ506945A patent/NZ506945A/en unknown
- 1999-02-25 AU AU29308/99A patent/AU755754B2/en not_active Ceased
- 1999-02-25 EP EP99910304A patent/EP1062206B1/en not_active Expired - Lifetime
- 1999-02-25 BR BR9908057-5A patent/BR9908057A/pt not_active Application Discontinuation
- 1999-02-25 ID IDW20001707A patent/ID26084A/id unknown
- 1999-03-08 AR ARP990100974A patent/AR019831A1/es unknown
- 1999-03-08 ZA ZA9901839A patent/ZA991839B/xx unknown
-
2000
- 2000-09-04 NO NO20004406A patent/NO317260B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU755754B2 (en) | 2002-12-19 |
| EP1062206B1 (en) | 2004-04-14 |
| CN1291977A (zh) | 2001-04-18 |
| IL137677A (en) | 2005-08-31 |
| KR20010041737A (ko) | 2001-05-25 |
| UA51838C2 (ru) | 2002-12-16 |
| IL137677A0 (en) | 2001-10-31 |
| NZ506945A (en) | 2002-06-28 |
| WO1999046254A3 (en) | 1999-10-21 |
| EP1062206A2 (en) | 2000-12-27 |
| PL344086A1 (en) | 2001-09-24 |
| TW528751B (en) | 2003-04-21 |
| PL193245B1 (pl) | 2007-01-31 |
| US6268362B1 (en) | 2001-07-31 |
| KR100603798B1 (ko) | 2006-07-25 |
| HUP0101046A3 (en) | 2002-12-28 |
| AU2930899A (en) | 1999-09-27 |
| ZA991839B (en) | 1999-12-22 |
| JP2002506066A (ja) | 2002-02-26 |
| CN1113867C (zh) | 2003-07-09 |
| DE69916438D1 (de) | 2004-05-19 |
| NO20004406D0 (no) | 2000-09-04 |
| WO1999046254A2 (en) | 1999-09-16 |
| ATE264302T1 (de) | 2004-04-15 |
| AR019831A1 (es) | 2002-03-20 |
| HUP0101046A2 (hu) | 2001-08-28 |
| GB9805080D0 (en) | 1998-05-06 |
| NO317260B1 (no) | 2004-09-27 |
| BR9908057A (pt) | 2000-10-31 |
| CA2321834A1 (en) | 1999-09-16 |
| NO20004406L (no) | 2000-10-30 |
| ID26084A (id) | 2000-11-23 |
| EA003333B1 (ru) | 2003-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |