HUP0101046A2 - Amiloidózis kezelésére alkalmazható amino-antraciklinon-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Amiloidózis kezelésére alkalmazható amino-antraciklinon-származékok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0101046A2 HUP0101046A2 HU0101046A HUP0101046A HUP0101046A2 HU P0101046 A2 HUP0101046 A2 HU P0101046A2 HU 0101046 A HU0101046 A HU 0101046A HU P0101046 A HUP0101046 A HU P0101046A HU P0101046 A2 HUP0101046 A2 HU P0101046A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen atom
- compounds
- amyloidosis
- treatment
- Prior art date
Links
- 206010002022 amyloidosis Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 diethylamino- Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány (1) általános képletű vegyületekre - amelyek képletében R1jelentése hidrogénatom, hidroxicsoport, -OR7 általános képletűcsoport, amelyben R7 jelentése 1-6 szénatomos alkilcsoport, 2-6szénatomos alkenilcsoport; R2 jelentése hidrogénatom; hidroxicsoport,dietil-amino-, piperidino-, tetrahidropiridino- vagy morfolinocsoport;R3 jelentése önmagában hidrogénatom vagy hidroxicsoport, valamint R4és R5 önmagában egymástól függetlenül hidrogénatom, hidroxicsoport,vagy R4 és R5 együtt a szénatommal karbonilcsoportot jelent; vagy R3és R4 együtt egy általános képletű csoportot képez, amelyben R8 és R9jelentése 1-6 szénatomos alkilcsoport, és R5 jelentése hidrogénatom;R6 jelentése hidrogénatom vagy fenilcsoport, amely adott esetbenmetil-, metoxicsoporttal vagy halogénatommal szubsztituált - ésgyógyászatilag elfogadható sóikra vonatkozik. A találmány kiterjed atalálmány szerinti vegyületeknek az amiloidózis kezelésére történőalkalmazására, a vegyületek előállítási eljárásaira, valamint avegyületeket tartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805080.0A GB9805080D0 (en) | 1998-03-10 | 1998-03-10 | Amino anthracyclinone derivatives |
| PCT/EP1999/001300 WO1999046254A2 (en) | 1998-03-10 | 1999-02-25 | Amino anthracyclinone derivatives and their use in the treatment of amyloidosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0101046A2 true HUP0101046A2 (hu) | 2001-08-28 |
| HUP0101046A3 HUP0101046A3 (en) | 2002-12-28 |
Family
ID=10828304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101046A HUP0101046A3 (en) | 1998-03-10 | 1999-02-25 | Amino anthracyclinone derivatives useful in the treatment of amyloidosis and medicines containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6268362B1 (hu) |
| EP (1) | EP1062206B1 (hu) |
| JP (1) | JP2002506066A (hu) |
| KR (1) | KR100603798B1 (hu) |
| CN (1) | CN1113867C (hu) |
| AR (1) | AR019831A1 (hu) |
| AT (1) | ATE264302T1 (hu) |
| AU (1) | AU755754B2 (hu) |
| BR (1) | BR9908057A (hu) |
| CA (1) | CA2321834A1 (hu) |
| DE (1) | DE69916438D1 (hu) |
| EA (1) | EA003333B1 (hu) |
| GB (1) | GB9805080D0 (hu) |
| HU (1) | HUP0101046A3 (hu) |
| ID (1) | ID26084A (hu) |
| IL (1) | IL137677A (hu) |
| NO (1) | NO317260B1 (hu) |
| NZ (1) | NZ506945A (hu) |
| PL (1) | PL193245B1 (hu) |
| TW (1) | TW528751B (hu) |
| UA (1) | UA51838C2 (hu) |
| WO (1) | WO1999046254A2 (hu) |
| ZA (1) | ZA991839B (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110264A1 (it) * | 2011-05-27 | 2012-11-28 | Univ Degli Studi Milano | Nuovi composti triciclici glicofusi, procedimento per la loro produzione e loro impiego quali ligandi dei peptidi ss amiloidi (ass). |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110289A (en) | 1993-08-06 | 1998-01-04 | Policlinico San Matteo Istitut | Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis |
| GB9416007D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| GB9516349D0 (en) | 1995-08-09 | 1995-10-11 | Pharmacia Spa | Aza-anthracyclinone derivatives |
| GB9613433D0 (en) * | 1996-06-26 | 1996-08-28 | Pharmacia Spa | Fluoro labelled anthracyclinone and anthracycline derivatives |
-
1998
- 1998-03-10 GB GBGB9805080.0A patent/GB9805080D0/en not_active Ceased
-
1999
- 1999-02-11 TW TW088102135A patent/TW528751B/zh not_active IP Right Cessation
- 1999-02-25 KR KR1020007009971A patent/KR100603798B1/ko not_active IP Right Cessation
- 1999-02-25 UA UA2000105718A patent/UA51838C2/uk unknown
- 1999-02-25 CA CA002321834A patent/CA2321834A1/en not_active Abandoned
- 1999-02-25 DE DE69916438T patent/DE69916438D1/de not_active Expired - Lifetime
- 1999-02-25 PL PL344086A patent/PL193245B1/pl not_active IP Right Cessation
- 1999-02-25 NZ NZ506945A patent/NZ506945A/en unknown
- 1999-02-25 IL IL13767799A patent/IL137677A/xx not_active IP Right Cessation
- 1999-02-25 HU HU0101046A patent/HUP0101046A3/hu unknown
- 1999-02-25 ID IDW20001707A patent/ID26084A/id unknown
- 1999-02-25 EA EA200000922A patent/EA003333B1/ru not_active IP Right Cessation
- 1999-02-25 CN CN99803596A patent/CN1113867C/zh not_active Expired - Fee Related
- 1999-02-25 EP EP99910304A patent/EP1062206B1/en not_active Expired - Lifetime
- 1999-02-25 AU AU29308/99A patent/AU755754B2/en not_active Ceased
- 1999-02-25 BR BR9908057-5A patent/BR9908057A/pt not_active Application Discontinuation
- 1999-02-25 WO PCT/EP1999/001300 patent/WO1999046254A2/en not_active Application Discontinuation
- 1999-02-25 AT AT99910304T patent/ATE264302T1/de not_active IP Right Cessation
- 1999-02-25 US US09/622,921 patent/US6268362B1/en not_active Expired - Fee Related
- 1999-02-25 JP JP2000535634A patent/JP2002506066A/ja not_active Withdrawn
- 1999-03-08 AR ARP990100974A patent/AR019831A1/es unknown
- 1999-03-08 ZA ZA9901839A patent/ZA991839B/xx unknown
-
2000
- 2000-09-04 NO NO20004406A patent/NO317260B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69916438D1 (de) | 2004-05-19 |
| IL137677A (en) | 2005-08-31 |
| NO317260B1 (no) | 2004-09-27 |
| UA51838C2 (uk) | 2002-12-16 |
| AU2930899A (en) | 1999-09-27 |
| TW528751B (en) | 2003-04-21 |
| EA200000922A1 (ru) | 2001-04-23 |
| EP1062206A2 (en) | 2000-12-27 |
| IL137677A0 (en) | 2001-10-31 |
| CN1113867C (zh) | 2003-07-09 |
| KR100603798B1 (ko) | 2006-07-25 |
| EP1062206B1 (en) | 2004-04-14 |
| AU755754B2 (en) | 2002-12-19 |
| EA003333B1 (ru) | 2003-04-24 |
| CN1291977A (zh) | 2001-04-18 |
| HUP0101046A3 (en) | 2002-12-28 |
| ZA991839B (en) | 1999-12-22 |
| PL344086A1 (en) | 2001-09-24 |
| GB9805080D0 (en) | 1998-05-06 |
| JP2002506066A (ja) | 2002-02-26 |
| AR019831A1 (es) | 2002-03-20 |
| NO20004406D0 (no) | 2000-09-04 |
| WO1999046254A2 (en) | 1999-09-16 |
| KR20010041737A (ko) | 2001-05-25 |
| ID26084A (id) | 2000-11-23 |
| PL193245B1 (pl) | 2007-01-31 |
| US6268362B1 (en) | 2001-07-31 |
| NZ506945A (en) | 2002-06-28 |
| BR9908057A (pt) | 2000-10-31 |
| CA2321834A1 (en) | 1999-09-16 |
| NO20004406L (no) | 2000-10-30 |
| ATE264302T1 (de) | 2004-04-15 |
| WO1999046254A3 (en) | 1999-10-21 |
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