EA199900736A1 - Эффективный синтез 1,4-дигидро 2h-3,1-бензоксазин-2-она - Google Patents

Эффективный синтез 1,4-дигидро 2h-3,1-бензоксазин-2-она

Info

Publication number
EA199900736A1
EA199900736A1 EA199900736A EA199900736A EA199900736A1 EA 199900736 A1 EA199900736 A1 EA 199900736A1 EA 199900736 A EA199900736 A EA 199900736A EA 199900736 A EA199900736 A EA 199900736A EA 199900736 A1 EA199900736 A1 EA 199900736A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzoxazin
dihydro
effective synthesis
chloroformate
dmp
Prior art date
Application number
EA199900736A
Other languages
English (en)
Other versions
EA001784B1 (ru
Inventor
Лайза Ф. Фрей
Ричард Д. Тилльер
Эдвард Дж. Дж. Грабовски
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9706082.6A external-priority patent/GB9706082D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199900736A1 publication Critical patent/EA199900736A1/ru
Publication of EA001784B1 publication Critical patent/EA001784B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Эффективный способ получения (-)-6-хлор-4-циклопропил-этинил-4-трифторметил-1,4-дигидро-2H-3,1-бензоксазин-2-она, известного также под названием DMP-266, являющегося ингибитором обратной транскриптазы, осуществляемый путем реакции циклизации промежуточного продукта, представляющего собой аминоспирт, с алкилхлорформиатом или арилхлорформиатом и основанием.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900736A 1997-02-12 1998-02-09 Эффективный синтез 1,4-дигидро 2н-3,1-бензоксазин-2-она EA001784B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3705997P 1997-02-12 1997-02-12
GBGB9706082.6A GB9706082D0 (en) 1997-03-24 1997-03-24 Efficient synthesis of A 1,4-dihydro-2H-3,1-benzoxazin-2-one
PCT/US1998/002495 WO1998034928A1 (en) 1997-02-12 1998-02-09 Efficient synthesis of a 1,4-dihydro-2h-3,1-benzoxazin-2-one

Publications (2)

Publication Number Publication Date
EA199900736A1 true EA199900736A1 (ru) 2000-02-28
EA001784B1 EA001784B1 (ru) 2001-08-27

Family

ID=26311250

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900736A EA001784B1 (ru) 1997-02-12 1998-02-09 Эффективный синтез 1,4-дигидро 2н-3,1-бензоксазин-2-она

Country Status (13)

Country Link
EP (1) EP0968197B1 (ru)
CN (1) CN1073992C (ru)
AR (1) AR011128A1 (ru)
AT (1) ATE294165T1 (ru)
AU (1) AU6152598A (ru)
BR (1) BR9807213A (ru)
DE (1) DE69829956T2 (ru)
EA (1) EA001784B1 (ru)
ES (1) ES2239798T3 (ru)
HR (1) HRP980056A2 (ru)
SK (1) SK108999A3 (ru)
TW (1) TW480253B (ru)
WO (1) WO1998034928A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
PE20060587A1 (es) * 2004-09-02 2006-07-09 Bristol Myers Squibb Co Sintesis de (s)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one

Also Published As

Publication number Publication date
WO1998034928A1 (en) 1998-08-13
ES2239798T3 (es) 2005-10-01
EA001784B1 (ru) 2001-08-27
EP0968197B1 (en) 2005-04-27
AR011128A1 (es) 2000-08-02
HRP980056A2 (en) 1998-12-31
DE69829956T2 (de) 2006-03-02
AU6152598A (en) 1998-08-26
ATE294165T1 (de) 2005-05-15
CN1073992C (zh) 2001-10-31
TW480253B (en) 2002-03-21
BR9807213A (pt) 2000-05-23
DE69829956D1 (de) 2005-06-02
CN1246852A (zh) 2000-03-08
SK108999A3 (en) 2000-05-16
EP0968197A1 (en) 2000-01-05

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU