PE20060587A1 - Sintesis de (s)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona - Google Patents
Sintesis de (s)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-onaInfo
- Publication number
- PE20060587A1 PE20060587A1 PE2005001003A PE2005001003A PE20060587A1 PE 20060587 A1 PE20060587 A1 PE 20060587A1 PE 2005001003 A PE2005001003 A PE 2005001003A PE 2005001003 A PE2005001003 A PE 2005001003A PE 20060587 A1 PE20060587 A1 PE 20060587A1
- Authority
- PE
- Peru
- Prior art keywords
- alkaline
- compound
- cyclopropyletinyl
- benzoxazin
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UN PROCESO QUE COMPRENDE: A) PONER EN CONTACTO UN COMPUESTO DE FORMULA I CON CLOROFORMIATO DE ALQUILO C1-C6 EN PRESENCIA DE UNA BASE TAL COMO FOSFATO MONOACIDO ALCALINO, CARBONATO ALCALINO, ALCOXIDO ALCALINO, ENTRE OTROS; UN SOLVENTE SELECCIONADO ENTRE THF, MeTHF, ACETATO DE ETILO, ENTRE OTROS A UNA TEMPERATURA DE 20-56°C PARA DAR UN COMPUESTO DE FORMULA II, DONDE R ES ALQUILO C1-C6; B) SEPARAR LA CAPA ORGANICA Y CONCENTRAR HASTA OBTENER II EN SOLUCION; C) PONER EN CONTACTO II CON UNA BASE DE PREFERENCIA NaOH, A UNA TEMPERATURA DE APROXIMADAMENTE 47-52°C PARA OBTENER EL COMPUESTO III. DICHO PROCESO PROPORCIONA ALTOS RENDIMIENTOS Y PRODUCE INTERMEDIARIOS ESTABLES. EL COMPUESTO (S)-6-CLORO-4-CICLOPROPILETINIL-4-TRIFLUOROMETIL-1,4-DIHIDRO-2H-3,1-BENZOXAZIN-2-ONA OBTENIDO ES INHIBIDOR DE LA TRANSCRIPTASA INVERSA DEL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH) UTIL EN EL TRATAMIENTO DEL SIDA / EFAVIRENZ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60670204P | 2004-09-02 | 2004-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060587A1 true PE20060587A1 (es) | 2006-07-09 |
Family
ID=36036924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005001003A PE20060587A1 (es) | 2004-09-02 | 2005-09-01 | Sintesis de (s)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona |
Country Status (17)
Country | Link |
---|---|
US (1) | US7205402B2 (es) |
EP (1) | EP1786791A4 (es) |
JP (1) | JP4980910B2 (es) |
KR (1) | KR20070061850A (es) |
CN (1) | CN101010307B (es) |
AR (1) | AR054082A1 (es) |
AU (1) | AU2005282576B2 (es) |
BR (1) | BRPI0514842A (es) |
CA (1) | CA2578966A1 (es) |
IL (1) | IL181678A (es) |
MX (1) | MX2007002235A (es) |
NO (1) | NO20071414L (es) |
PE (1) | PE20060587A1 (es) |
RU (1) | RU2385868C2 (es) |
TW (1) | TWI354667B (es) |
WO (1) | WO2006029079A2 (es) |
ZA (1) | ZA200701873B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7740693B2 (en) * | 2007-10-01 | 2010-06-22 | Honeywell International Inc. | Organic fluorescent sulfonyl ureido benzoxazinone pigments |
WO2011005871A1 (en) | 2009-07-07 | 2011-01-13 | Pgxhealth, Llc | Substituted 8-[6-carbonylamine-3-pyridyl]xanthines as adenosine a2b antagonists |
US8080655B2 (en) * | 2009-07-20 | 2011-12-20 | Apotex Pharmachem Inc. | Methods of making efavirenz and intermediates thereof |
DE102009041443A1 (de) | 2009-09-16 | 2011-03-31 | Archimica Gmbh | Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz |
EP2447255A1 (en) * | 2010-10-14 | 2012-05-02 | Lonza Ltd. | Process for the synthesis of cyclic carbamates |
EP2471783A1 (en) | 2010-12-23 | 2012-07-04 | Esteve Química, S.A. | Novel polymorphic form of efavirenz |
CN103508973B (zh) * | 2012-06-25 | 2016-04-27 | 上海迪赛诺药业有限公司 | 制备依非韦伦i型结晶的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6081182A (ja) * | 1983-10-12 | 1985-05-09 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
US5922864A (en) * | 1997-02-12 | 1999-07-13 | Merck & Co., Inc. | Efficient synthesis of a 1,4-dihydro2H-3,1-benzoxazin-2-one |
TW480253B (en) * | 1997-02-12 | 2002-03-21 | Merck & Co Inc | Efficient synthesis of a 1,4-dihydro-2H-3,1-benzoxazin-2-one |
PL338894A1 (en) * | 1997-09-03 | 2000-11-20 | Merck & Co Inc | Method of increasing optical purity of 2r-[1-hydroxy-1-trifluoromethy-3-cyclopropylopropin-2-yl]-4-chloroaniline |
HRP990182A2 (en) * | 1998-06-11 | 2000-02-29 | Du Pont Pharm Co | Crystalline efavirenz |
-
2005
- 2005-09-01 US US11/217,892 patent/US7205402B2/en active Active
- 2005-09-01 PE PE2005001003A patent/PE20060587A1/es not_active Application Discontinuation
- 2005-09-02 MX MX2007002235A patent/MX2007002235A/es active IP Right Grant
- 2005-09-02 AR ARP050103697A patent/AR054082A1/es unknown
- 2005-09-02 BR BRPI0514842-1A patent/BRPI0514842A/pt not_active IP Right Cessation
- 2005-09-02 TW TW094130204A patent/TWI354667B/zh not_active IP Right Cessation
- 2005-09-02 JP JP2007530448A patent/JP4980910B2/ja not_active Expired - Fee Related
- 2005-09-02 EP EP05794096A patent/EP1786791A4/en not_active Withdrawn
- 2005-09-02 CN CN2005800292352A patent/CN101010307B/zh not_active Expired - Fee Related
- 2005-09-02 AU AU2005282576A patent/AU2005282576B2/en not_active Ceased
- 2005-09-02 CA CA002578966A patent/CA2578966A1/en not_active Abandoned
- 2005-09-02 WO PCT/US2005/031541 patent/WO2006029079A2/en active Application Filing
- 2005-09-02 KR KR1020077007447A patent/KR20070061850A/ko not_active Application Discontinuation
- 2005-09-02 RU RU2007112006/04A patent/RU2385868C2/ru not_active IP Right Cessation
-
2007
- 2007-03-01 IL IL181678A patent/IL181678A/en not_active IP Right Cessation
- 2007-03-02 ZA ZA200701873A patent/ZA200701873B/xx unknown
- 2007-03-15 NO NO20071414A patent/NO20071414L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US20060047115A1 (en) | 2006-03-02 |
IL181678A (en) | 2012-01-31 |
KR20070061850A (ko) | 2007-06-14 |
MX2007002235A (es) | 2007-04-23 |
CA2578966A1 (en) | 2006-03-16 |
NO20071414L (no) | 2007-03-15 |
IL181678A0 (en) | 2007-07-04 |
AR054082A1 (es) | 2007-06-06 |
AU2005282576A1 (en) | 2006-03-16 |
TW200621735A (en) | 2006-07-01 |
US7205402B2 (en) | 2007-04-17 |
EP1786791A2 (en) | 2007-05-23 |
BRPI0514842A (pt) | 2008-06-24 |
CN101010307B (zh) | 2011-10-19 |
WO2006029079A2 (en) | 2006-03-16 |
RU2007112006A (ru) | 2008-10-10 |
EP1786791A4 (en) | 2009-04-15 |
TWI354667B (en) | 2011-12-21 |
ZA200701873B (en) | 2008-09-25 |
RU2385868C2 (ru) | 2010-04-10 |
JP4980910B2 (ja) | 2012-07-18 |
WO2006029079A3 (en) | 2006-06-01 |
CN101010307A (zh) | 2007-08-01 |
JP2008511682A (ja) | 2008-04-17 |
AU2005282576B2 (en) | 2011-11-24 |
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Legal Events
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FC | Refusal | ||
FG | Grant, registration | ||
FD | Application declared void or lapsed |