BR9807213A - Processo para a preparação de 1,4-di-hidro-2h-3,1-benzoxazin-2-ona, e, carbamato de alquila. - Google Patents

Processo para a preparação de 1,4-di-hidro-2h-3,1-benzoxazin-2-ona, e, carbamato de alquila.

Info

Publication number
BR9807213A
BR9807213A BR9807213-7A BR9807213A BR9807213A BR 9807213 A BR9807213 A BR 9807213A BR 9807213 A BR9807213 A BR 9807213A BR 9807213 A BR9807213 A BR 9807213A
Authority
BR
Brazil
Prior art keywords
benzoxazin
dihydro
preparation
alkyl carbamate
alkyl
Prior art date
Application number
BR9807213-7A
Other languages
English (en)
Inventor
Lisa F Frey
Richard D Tillyer
Edward J J Grabowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9706082.6A external-priority patent/GB9706082D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BR9807213A publication Critical patent/BR9807213A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE 1,4-DI-HIDRO-2H-3,1- BENZOXAZIN-2-ONA" Um eficiente processo para preparar um composto de (-)-6-cloro-4-ciclopropilaetinila-4-trifluormetila-1,4-di-hidro-2H-3,1-ben zoxazin-2-ona também conhecido como DMP-266, um inibidor de transcriptase reversa é obtido usando uma reação de ciclização do amino álcool intermediário com um cloroformiato de alquila ou arila e uma base.
BR9807213-7A 1997-02-12 1998-02-09 Processo para a preparação de 1,4-di-hidro-2h-3,1-benzoxazin-2-ona, e, carbamato de alquila. BR9807213A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3705997P 1997-02-12 1997-02-12
GBGB9706082.6A GB9706082D0 (en) 1997-03-24 1997-03-24 Efficient synthesis of A 1,4-dihydro-2H-3,1-benzoxazin-2-one
PCT/US1998/002495 WO1998034928A1 (en) 1997-02-12 1998-02-09 Efficient synthesis of a 1,4-dihydro-2h-3,1-benzoxazin-2-one

Publications (1)

Publication Number Publication Date
BR9807213A true BR9807213A (pt) 2000-05-23

Family

ID=26311250

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807213-7A BR9807213A (pt) 1997-02-12 1998-02-09 Processo para a preparação de 1,4-di-hidro-2h-3,1-benzoxazin-2-ona, e, carbamato de alquila.

Country Status (13)

Country Link
EP (1) EP0968197B1 (pt)
CN (1) CN1073992C (pt)
AR (1) AR011128A1 (pt)
AT (1) ATE294165T1 (pt)
AU (1) AU6152598A (pt)
BR (1) BR9807213A (pt)
DE (1) DE69829956T2 (pt)
EA (1) EA001784B1 (pt)
ES (1) ES2239798T3 (pt)
HR (1) HRP980056A2 (pt)
SK (1) SK108999A3 (pt)
TW (1) TW480253B (pt)
WO (1) WO1998034928A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
PE20060587A1 (es) * 2004-09-02 2006-07-09 Bristol Myers Squibb Co Sintesis de (s)-6-cloro-4-ciclopropiletinil-4-trifluorometil-1,4-dihidro-2h-3,1-benzoxazin-2-ona

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one

Also Published As

Publication number Publication date
WO1998034928A1 (en) 1998-08-13
ES2239798T3 (es) 2005-10-01
EA001784B1 (ru) 2001-08-27
EP0968197B1 (en) 2005-04-27
AR011128A1 (es) 2000-08-02
HRP980056A2 (en) 1998-12-31
DE69829956T2 (de) 2006-03-02
AU6152598A (en) 1998-08-26
ATE294165T1 (de) 2005-05-15
CN1073992C (zh) 2001-10-31
TW480253B (en) 2002-03-21
EA199900736A1 (ru) 2000-02-28
DE69829956D1 (de) 2005-06-02
CN1246852A (zh) 2000-03-08
SK108999A3 (en) 2000-05-16
EP0968197A1 (en) 2000-01-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1887 DE 06/03/2007.