EA199900600A1 - Производные пиразола - Google Patents

Производные пиразола

Info

Publication number
EA199900600A1
EA199900600A1 EA199900600A EA199900600A EA199900600A1 EA 199900600 A1 EA199900600 A1 EA 199900600A1 EA 199900600 A EA199900600 A EA 199900600A EA 199900600 A EA199900600 A EA 199900600A EA 199900600 A1 EA199900600 A1 EA 199900600A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
atom
substituents
phenyl
hydrogen atom
Prior art date
Application number
EA199900600A
Other languages
English (en)
Other versions
EA002101B1 (ru
Inventor
Акио Эдзима
Сатору Охсуки
Original Assignee
Дайити Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко., Лтд. filed Critical Дайити Фармасьютикал Ко., Лтд.
Publication of EA199900600A1 publication Critical patent/EA199900600A1/ru
Publication of EA002101B1 publication Critical patent/EA002101B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединение, представленное формулой (I), или его соль;где Rи R, которые могут быть одними и теми же или различаться, каждый представляет собой атом водорода, атом галогена, гидроксильную группу, алкоксильную группу, аминогруппу, алкиламиногруппу, арильную группу или алкильную группу; Rи R, которые могут быть одними и теми же или различаться, каждый представляет собой атом водорода, атом галогена, алкоксильную группу, аминогруппу, алкиламиногруппу, арильную группу или алкильную группу; Rпредставляет собой атом водорода, алкильную группу, алкенильную группу, алкинильную группу, арильную группу или арилалкильную группу; Q представляет собой амидиногруппу, циклоалкильную группу, фенильную группу или группу в виде моноциклического гетероцикла, за исключением пиримидинильной группы, связанной с атомом N во 2-ом положении; G представляет собой содержащую азот насыщенную гетероциклическую структуру, представленную формулойгде Xпредставляет собой атом азота или CH, в этой структуре кольцо может иметь кетогруппу, а также может иметь один или более заместителей; Z представляет собой фенильную или гетероциклическую группу, которая может иметь один или более заместителей, в которой два заместителя в фенильной или гетероциклической группе могут быть соединены друг с другом, образуя кольцо, что в целом дает конденсированную бициклическую структуру; заместитель в Z и заместитель в G могут быть соединены друг с другом, образуя в целом конденсированную трициклическую или тетрациклическую структуру, и противоопухолевый агент, содержащий в качестве активного ингредиента это соединение или его соль.Международная заявка была опубликована вместе с отчетом о
EA199900600A 1997-01-27 1998-01-26 Производные пиразола EA002101B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1211697 1997-01-27
PCT/JP1998/000300 WO1998032739A1 (fr) 1997-01-27 1998-01-26 Derives de pirazole

Publications (2)

Publication Number Publication Date
EA199900600A1 true EA199900600A1 (ru) 2000-04-24
EA002101B1 EA002101B1 (ru) 2001-12-24

Family

ID=11796592

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900600A EA002101B1 (ru) 1997-01-27 1998-01-26 Производные пиразола

Country Status (10)

Country Link
EP (1) EP1022270A4 (ru)
KR (1) KR20000070523A (ru)
CN (1) CN1105707C (ru)
AU (1) AU724394B2 (ru)
CA (1) CA2278677A1 (ru)
EA (1) EA002101B1 (ru)
ID (1) ID22017A (ru)
NO (1) NO314260B1 (ru)
TW (1) TW486478B (ru)
WO (1) WO1998032739A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
WO2000005230A1 (fr) * 1998-07-24 2000-02-03 Daiichi Pharmaceutical Co., Ltd. Derives de pyrazole et sels correspondants
EP2266973A1 (de) 2009-05-29 2010-12-29 Bayer CropScience AG Pyrazinylpyrazole
EP2499130A1 (de) 2009-11-11 2012-09-19 Bayer CropScience AG Neue diazinyl-pyrazolylverbindungen
KR101663637B1 (ko) * 2009-11-13 2016-10-07 제노스코 키나아제 억제제
CN108430976B (zh) * 2015-12-16 2022-07-05 日本曹达株式会社 芳基唑化合物和有害生物防除剂
TW202120478A (zh) * 2019-11-22 2021-06-01 美商富曼西公司 用於合成(3-氯-2-吡啶基)肼的新穎製程

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472857A (en) * 1966-02-03 1969-10-14 Ciba Ltd N-(3-pyrazolyl-propyl)-n'-phenyl piperazines
JPS61129129A (ja) * 1984-11-28 1986-06-17 Kureha Chem Ind Co Ltd 抗腫瘍剤
CA1279645C (en) * 1986-02-27 1991-01-29 Ineke Van Wijngaarden Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties
US4808621A (en) * 1986-07-07 1989-02-28 Warner-Lambert Company Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
TW312694B (ru) * 1994-09-26 1997-08-11 Daiichi Seiyaku Co

Also Published As

Publication number Publication date
ID22017A (id) 1999-08-26
CN1251578A (zh) 2000-04-26
CA2278677A1 (en) 1998-07-30
TW486478B (en) 2002-05-11
EA002101B1 (ru) 2001-12-24
KR20000070523A (ko) 2000-11-25
CN1105707C (zh) 2003-04-16
NO314260B1 (no) 2003-02-24
AU724394B2 (en) 2000-09-21
NO993628D0 (no) 1999-07-26
EP1022270A1 (en) 2000-07-26
EP1022270A4 (en) 2002-01-30
NO993628L (no) 1999-09-22
WO1998032739A1 (fr) 1998-07-30
AU5577198A (en) 1998-08-18

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU