EA199800721A1 - Ингибитор реваскуляризации - Google Patents

Ингибитор реваскуляризации

Info

Publication number
EA199800721A1
EA199800721A1 EA199800721A EA199800721A EA199800721A1 EA 199800721 A1 EA199800721 A1 EA 199800721A1 EA 199800721 A EA199800721 A EA 199800721A EA 199800721 A EA199800721 A EA 199800721A EA 199800721 A1 EA199800721 A1 EA 199800721A1
Authority
EA
Eurasian Patent Office
Prior art keywords
endothelial cells
revascularization
capillary
human
rehivkularization
Prior art date
Application number
EA199800721A
Other languages
English (en)
Inventor
Масаюки Исадзи
Хироси Мията
Юкиеси Адзисава
Original Assignee
Киссеи Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Киссеи Фармасьютикал Ко., Лтд. filed Critical Киссеи Фармасьютикал Ко., Лтд.
Publication of EA199800721A1 publication Critical patent/EA199800721A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение относится к ингибитору реваскуляризации, содержащему в качестве активного ингредиента N-(3,4-диметоксициннамоил)антраниловую кислоту формулы:или ее фармацевтически приемлемую соль, который обладает ингибирующим действием на пролиферацию и хемотаксис капиллярных эндотелиальных клеток человека и каналообразование капиллярных эндотелиальных клеток человека и, следовательно, применим в качестве средства для предупреждения и лечения заболеваний, связанных с реваскуляризацией, таких как диабетическая ретинопатия, старческая дисковидная дегенерация желтого пятна, реваскулярная глаукома и ревматический артрит.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800721A 1996-02-15 1997-02-12 Ингибитор реваскуляризации EA199800721A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6509496 1996-02-15
PCT/JP1997/000354 WO1997029744A1 (fr) 1996-02-15 1997-02-12 Inhibiteur de la neoformation de vaisseaux sanguins

Publications (1)

Publication Number Publication Date
EA199800721A1 true EA199800721A1 (ru) 1999-02-25

Family

ID=13277001

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800721A EA199800721A1 (ru) 1996-02-15 1997-02-12 Ингибитор реваскуляризации

Country Status (11)

Country Link
US (1) US6407139B1 (ru)
EP (1) EP0894496A4 (ru)
KR (1) KR19990082523A (ru)
CN (1) CN1211182A (ru)
BR (1) BR9707514A (ru)
CA (1) CA2246418A1 (ru)
CZ (1) CZ258598A3 (ru)
EA (1) EA199800721A1 (ru)
NO (1) NO983719L (ru)
NZ (1) NZ331339A (ru)
WO (1) WO1997029744A1 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2196366T3 (es) * 1996-09-28 2003-12-16 Kissei Pharmaceutical Inhibidor de turbidez sub-epitelial.
CA2267320A1 (en) * 1996-10-14 1998-04-23 Hiroshi Miyata Secondary cataract inhibitor
CA2286120A1 (en) * 1997-04-18 1998-10-29 Kissei Pharmaceutical Co., Ltd. Preventives or remedies for diseases affecting excessive proliferation of retinal pigment epithelial cells
AU757680B2 (en) 1999-07-01 2003-02-27 Taisho Pharmaceutical Co., Ltd. Aminobenzoic acid derivatives
EP1229010A1 (en) * 1999-10-01 2002-08-07 Japan Energy Corporation Novel diarylamide derivatives and use thereof as medicines
US7531575B2 (en) * 2002-10-31 2009-05-12 Eberhard-Karls-Universität Tübingin Method of modulating cellular activity and agents useful for same
US20050106230A1 (en) * 2003-11-17 2005-05-19 Young Janel E. Drug-enhanced adhesion prevention
US20080009519A1 (en) * 2004-11-17 2008-01-10 Lawrence Steinman Method of modulating t cell functioning
ZA200704871B (en) * 2004-11-17 2008-09-25 Angiogen Pharmaceuticals Pty L A method of modulating B cell functioning
KR20080016859A (ko) * 2005-05-16 2008-02-22 앤지오젠 파마슈티칼스 피티와이. 리미티드 통증의 치료를 위한 방법 및 조성물
AU2007271734B2 (en) 2006-07-05 2012-03-29 Certa Therapeutics Pty. Ltd. Therapeutic compounds
JP2008247789A (ja) * 2007-03-30 2008-10-16 Kissei Pharmaceut Co Ltd クローン病に伴う腸管狭窄の進展抑制用医薬組成物
WO2009032202A1 (en) * 2007-08-29 2009-03-12 Nuon Therapeutics, Inc. Treatment of brain disorders
KR101593708B1 (ko) 2007-12-21 2016-02-12 피브로테크 세라퓨틱 피티와이 엘티디 항섬유증 제제의 할로겐화 유사체
JP2011006406A (ja) * 2009-05-29 2011-01-13 Santen Pharmaceut Co Ltd トラニラストを含有する網膜疾患の予防または治療剤
EP2455077B1 (en) 2009-06-17 2014-06-11 National University Corporation Kumamoto University Prophylactic and/or therapeutic agent for dysmenorrhea
US9062076B2 (en) 2009-10-22 2015-06-23 Fibrotech Therapeutics Pty Ltd Fused ring analogues of anti-fibrotic agents
WO2012068612A1 (en) 2010-11-24 2012-05-31 Fibrotech Therapeutics Pty Ltd Methods of treating eye diseases associated with inflammation and vascular proliferation
CN102657647A (zh) * 2012-04-06 2012-09-12 澳门大学 Ic-4在抗血管新生中的应用
CN110546133A (zh) 2017-02-03 2019-12-06 塞尔塔治疗有限公司 抗纤维化化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05163222A (ja) 1991-12-18 1993-06-29 Kissei Pharmaceut Co Ltd コラーゲン過剰合成疾患治療剤
JP2617407B2 (ja) * 1992-09-14 1997-06-04 キッセイ薬品工業株式会社 血管内膜細胞過剰増殖疾患の予防および治療剤
US5512591A (en) * 1993-02-18 1996-04-30 President And Fellows Of Harvard College Treatments for diseases characterized by neovascularization
EP0761251B1 (en) * 1994-10-17 2004-12-29 Kabushikikaisha Igaki Iryo Sekkei Drug-releasing stent
EP0761720B1 (de) * 1995-08-31 2001-02-28 Infineon Technologies AG Verfahren zur Herstellung von Poly-o-hydroxyamiden und Poly-o-mercaptoamiden
ES2151464T3 (es) * 1996-02-07 2002-12-16 Lead Chem Co Ltd Preparacion para aplicacion externa que comprende tranilast y procedimiento para producirla.

Also Published As

Publication number Publication date
EP0894496A1 (en) 1999-02-03
BR9707514A (pt) 1999-07-27
EP0894496A4 (en) 2001-01-03
CN1211182A (zh) 1999-03-17
US6407139B1 (en) 2002-06-18
CZ258598A3 (cs) 1998-11-11
NZ331339A (en) 2001-02-23
WO1997029744A1 (fr) 1997-08-21
KR19990082523A (ko) 1999-11-25
NO983719L (no) 1998-10-14
NO983719D0 (no) 1998-08-13
CA2246418A1 (en) 1997-08-21

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