EA199800466A1 - Замещеное производное аминоциклоалкилпирролидона - Google Patents

Замещеное производное аминоциклоалкилпирролидона

Info

Publication number
EA199800466A1
EA199800466A1 EA199800466A EA199800466A EA199800466A1 EA 199800466 A1 EA199800466 A1 EA 199800466A1 EA 199800466 A EA199800466 A EA 199800466A EA 199800466 A EA199800466 A EA 199800466A EA 199800466 A1 EA199800466 A1 EA 199800466A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aminocycloalkylpyrrolidone
substituted derivative
chem
represented
formula
Prior art date
Application number
EA199800466A
Other languages
English (en)
Other versions
EA003321B1 (ru
Inventor
Макото Такемура
Юити Кимура
Хисаси Такахаси
Кенити Кимура
Сатору Мияути
Хитоси Оки
Original Assignee
Дайити Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко., Лтд. filed Critical Дайити Фармасьютикал Ко., Лтд.
Publication of EA199800466A1 publication Critical patent/EA199800466A1/ru
Publication of EA003321B1 publication Critical patent/EA003321B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предложены антибактериальные лекарственные средства, обладающие прекрасной антибактериальной активностью и высокой безвредностью, которые содержат в качестве активного ингредиента производные хинолона, содержащие в качестве заместителя аминоциклоалкилпирролидин и дополнительно замещенные различными заместителями, которые имеют формулу (I), его соли и гидраты:где фрагмент Q представляет собой формулу (II) или (IV):илиМеждународная заявка была опубликована вместе с отчетом о международном поиске.
EA199800466A 1995-11-22 1996-11-22 Производные аминоциклоалкилпирролидона и антибактериальное лекарственное средство на их основе EA003321B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30412995 1995-11-22
JP19263796 1996-07-23
PCT/JP1996/003440 WO1997019072A1 (fr) 1995-11-22 1996-11-22 Derives a base d'aminocycloalkylpyrrolidine substituee

Publications (2)

Publication Number Publication Date
EA199800466A1 true EA199800466A1 (ru) 1998-12-24
EA003321B1 EA003321B1 (ru) 2003-04-24

Family

ID=26507439

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800466A EA003321B1 (ru) 1995-11-22 1996-11-22 Производные аминоциклоалкилпирролидона и антибактериальное лекарственное средство на их основе

Country Status (15)

Country Link
EP (1) EP0911328B1 (ru)
JP (1) JP4040091B2 (ru)
KR (1) KR19990071558A (ru)
CN (1) CN1119343C (ru)
AT (1) ATE317393T1 (ru)
CA (1) CA2238765A1 (ru)
DE (1) DE69635812T2 (ru)
DK (1) DK0911328T3 (ru)
EA (1) EA003321B1 (ru)
ES (1) ES2258780T3 (ru)
NO (1) NO316516B1 (ru)
NZ (1) NZ322202A (ru)
PT (1) PT911328E (ru)
TW (1) TW402601B (ru)
WO (1) WO1997019072A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2212007C (en) * 1995-02-02 2004-09-14 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group
BR9810235A (pt) * 1997-05-21 2001-09-18 Daiichi Seiyaku Co Derivados de aminocicloalquil-pirrolidina cis-substituìda
MY119816A (en) * 1997-05-30 2005-07-29 Daiichi Seiyaku Co Substituted cyclobutylamine derivatives
BR9812644B1 (pt) 1997-09-15 2010-07-13 quinolonas antimicrobianas, composição farmacêutica e uso das mesmas.
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions
EP1258478A4 (en) * 2000-02-25 2006-03-15 Daiichi Seiyaku Co PROCESS FOR THE PREPARATION OF CHINOLONCARBOXYLIC ACIDS AND THEIR INTERMEDIATE PRODUCTS
US6825353B2 (en) 2000-02-25 2004-11-30 Daiichi Pharmaceutical Co., Ltd. Process for producing quinolonecarboxylic acids and intermediates thereof
US20040063754A1 (en) 2000-11-20 2004-04-01 Hisashi Takahashi Dehalogeno compounds
JP4616770B2 (ja) 2003-06-19 2011-01-19 第一三共株式会社 選択的なアミノ置換基導入法
ES2402420T3 (es) * 2003-09-29 2013-05-03 Daiichi Sankyo Company, Limited Derivado del ácido 8-cianoquinolonacarboxílico
JP4876165B2 (ja) 2006-03-28 2012-02-15 ザ プロクター アンド ギャンブル カンパニー キノロン中間体を調製するための水素化物還元法
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
WO2007110834A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
WO2010069793A1 (en) * 2008-12-16 2010-06-24 F. Hoffmann-La Roche Ag Process for the preparation of pyrollidine-3-carboxylic acids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79189A (en) * 1985-06-26 1990-07-12 Daiichi Seiyaku Co Quinoline and/or naphthyridine-4-oxo-3-carboxylic acid derivatives,process for their preparation and pharmaceutical compositions comprising them
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
DE69231422T2 (de) * 1991-05-28 2001-03-29 Daiichi Pharmaceutical Co., Ltd. Pyridoncarbonsäurederivate
CA2212007C (en) * 1995-02-02 2004-09-14 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives substitued by a bicyclic amino group

Also Published As

Publication number Publication date
NO316516B1 (no) 2004-02-02
EP0911328A1 (en) 1999-04-28
NZ322202A (en) 2000-05-26
JP4040091B2 (ja) 2008-01-30
NO982297L (no) 1998-07-22
AU7589896A (en) 1997-06-11
WO1997019072A1 (fr) 1997-05-29
CN1119343C (zh) 2003-08-27
ATE317393T1 (de) 2006-02-15
CN1207738A (zh) 1999-02-10
EP0911328A4 (ru) 1999-04-28
DE69635812T2 (de) 2006-10-19
TW402601B (en) 2000-08-21
EP0911328B1 (en) 2006-02-08
DK0911328T3 (da) 2006-06-06
ES2258780T3 (es) 2006-09-01
KR19990071558A (ko) 1999-09-27
CA2238765A1 (en) 1997-05-29
NO982297D0 (no) 1998-05-20
PT911328E (pt) 2006-05-31
AU707889B2 (en) 1999-07-22
EA003321B1 (ru) 2003-04-24
DE69635812D1 (de) 2006-04-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU