EA036623B1 - Стабильные белковые композиции - Google Patents
Стабильные белковые композиции Download PDFInfo
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- EA036623B1 EA036623B1 EA201890979A EA201890979A EA036623B1 EA 036623 B1 EA036623 B1 EA 036623B1 EA 201890979 A EA201890979 A EA 201890979A EA 201890979 A EA201890979 A EA 201890979A EA 036623 B1 EA036623 B1 EA 036623B1
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- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Peptides Or Proteins (AREA)
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| PCT/US2016/057019 WO2017066554A1 (en) | 2015-10-16 | 2016-10-14 | Stable protein compositions |
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| IL258570B2 (en) * | 2015-10-16 | 2024-07-01 | Regeneron Pharma | Stable protein preparations |
| US12156900B2 (en) | 2017-11-17 | 2024-12-03 | Amgen Inc. | VEGFR-Fc fusion protein formulations |
| PT4364724T (pt) | 2018-05-10 | 2025-12-16 | Regeneron Pharma | Formulações contendo uma proteína de fusão do recetor do vegf de concentração elevada |
| US20220054586A1 (en) * | 2018-09-10 | 2022-02-24 | Samsung Bioepis Co., Ltd. | Liquid composition comprising protein |
| CN112294760B (zh) * | 2019-07-26 | 2025-12-12 | 宁波新致生物科技有限公司 | 一种液体制剂及其应用 |
| WO2025235973A1 (en) * | 2024-05-09 | 2025-11-13 | Deep Brain Bci Corporation | Implantable medical devices for delivering therapeutics and brain-computer interface systems |
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| US20120095439A1 (en) * | 2010-01-29 | 2012-04-19 | De Juan Jr Eugene | Implantable therapeutic device |
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| US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
| RU2357750C2 (ru) * | 2002-12-31 | 2009-06-10 | Элтус Фармасьютикалз Инк. | Кристаллы человеческого гормона роста и способы их получения |
| CA2530113C (en) * | 2003-06-26 | 2013-08-13 | Control Delivery Systems, Inc. | Bioerodible sustained release drug delivery systems |
| CA2588449A1 (en) * | 2004-11-24 | 2006-06-01 | Therakine Corporation | An implant for intraocular drug delivery |
| CN104434770A (zh) | 2006-06-16 | 2015-03-25 | 瑞泽恩制药公司 | 适合玻璃体内施用的vegf拮抗剂的制剂 |
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| EP3000434A1 (en) | 2007-03-16 | 2016-03-30 | The Regents Of The University Of California | Nanostructure surface coated medical implants and methods of using the same |
| SG173167A1 (en) * | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
| CN101559041B (zh) * | 2009-05-19 | 2014-01-15 | 中国科学院过程工程研究所 | 粒径均一的多肽药物缓释微球或微囊制剂及制备方法 |
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| BR112014029760A2 (pt) | 2012-05-30 | 2017-06-27 | Univ California | dispositivos de distribuição de agente bioativo e métodos para fazer e usar os mesmos |
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| US20120095439A1 (en) * | 2010-01-29 | 2012-04-19 | De Juan Jr Eugene | Implantable therapeutic device |
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| ATHA D H, INGHAM K C: "MECHANISM OF PRECIPITATION OF PROTEINS BY POLY ETHYLENE GLYCOLS ANALYSIS IN TERMS OF EXCLUDED VOLUME", JOURNAL OF BIOLOGICAL CHEMISTRY.(MICROFILMS), AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD., US, vol. 256, no. 23, 1 January 1981 (1981-01-01), US, pages 12108 - 12117, XP002454548 * |
| SANDRA HERRMANN ; SILKE MOHL ; FLORENCE SIEPMANN ; JUERGEN SIEPMANN ; GERHARD WINTER: "New Insight into the Role of Polyethylene Glycol Acting as Protein Release Modifier in Lipidic Implants", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 24, no. 8, 23 March 2007 (2007-03-23), NL, pages 1527 - 1537, XP019507255, ISSN: 1573-904X, DOI: 10.1007/s11095-007-9271-y * |
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| MY199546A (en) | 2023-11-06 |
| AU2022200475A1 (en) | 2022-02-17 |
| CN108348462A (zh) | 2018-07-31 |
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