EA201890979A1 - Стабильные белковые композиции - Google Patents
Стабильные белковые композицииInfo
- Publication number
- EA201890979A1 EA201890979A1 EA201890979A EA201890979A EA201890979A1 EA 201890979 A1 EA201890979 A1 EA 201890979A1 EA 201890979 A EA201890979 A EA 201890979A EA 201890979 A EA201890979 A EA 201890979A EA 201890979 A1 EA201890979 A1 EA 201890979A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- therapeutic biomolecule
- biomolecule
- therapeutic
- porous structure
- environment
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 5
- 238000012377 drug delivery Methods 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Peptides Or Proteins (AREA)
Abstract
Описаны стабильные фармацевтические лекарственные формы и устройства доставки лекарственных средств. В некоторых вариантах реализации изобретения устройство доставки лекарственного средства содержит резервуар, который после имплантации в организм пациента находится в частичном контакте с тканевой окружающей средой. Резервуар остается в контакте с окружающей средой с помощью пористой структуры в корпусе устройства доставки. Резервуар содержит комбинацию терапевтической биомолекулы и второй молекулы, которая служит для стабилизации и ограничения растворимости терапевтической биомолекулы, тем самым контролируя количество терапевтической биомолекулы, которое находится в растворе. Концентрация растворимой терапевтической биомолекулы или размер площади поверхности пористой структуры контролируют скорость доставки терапевтической биомолекулы к целевой ткани.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562242412P | 2015-10-16 | 2015-10-16 | |
PCT/US2016/057019 WO2017066554A1 (en) | 2015-10-16 | 2016-10-14 | Stable protein compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201890979A1 true EA201890979A1 (ru) | 2018-10-31 |
EA036623B1 EA036623B1 (ru) | 2020-12-01 |
Family
ID=57209897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890979A EA036623B1 (ru) | 2015-10-16 | 2016-10-14 | Стабильные белковые композиции |
Country Status (12)
Country | Link |
---|---|
US (1) | US20180289623A1 (ru) |
EP (1) | EP3362041A1 (ru) |
JP (3) | JP6853245B2 (ru) |
KR (1) | KR20180063311A (ru) |
CN (2) | CN108348462B (ru) |
AU (2) | AU2016340072B2 (ru) |
CA (1) | CA3001346A1 (ru) |
EA (1) | EA036623B1 (ru) |
IL (2) | IL310557A (ru) |
MX (2) | MX2018004695A (ru) |
MY (1) | MY193964A (ru) |
WO (1) | WO2017066554A1 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11291636B2 (en) | 2011-11-18 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA036623B1 (ru) * | 2015-10-16 | 2020-12-01 | Ридженерон Фармасьютикалз, Инк. | Стабильные белковые композиции |
US20200338164A1 (en) * | 2017-11-17 | 2020-10-29 | Amgen Inc. | Vegfr-fc fusion protein formulations |
JOP20200275A1 (ar) | 2018-05-10 | 2020-11-02 | Regeneron Pharma | صيغ تحتوي على بروتين اندماج لمستقبلvegf مرتفعة التركيز |
KR20200029374A (ko) * | 2018-09-10 | 2020-03-18 | 삼성바이오에피스 주식회사 | 단백질을 포함하는 액상 조성물 |
CN112294760A (zh) * | 2019-07-26 | 2021-02-02 | 张晋宇 | 一种液体制剂及其应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0661989T3 (da) * | 1992-09-21 | 1998-03-02 | Upjohn Co | Proteinsammensætninger med vedvarende frigivelse |
US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
BR0317888A (pt) * | 2002-12-31 | 2005-12-06 | Altus Pharmaceuticals Inc | Cristais do hormÈnio do crescimento humano e processos para preparação dos mesmos |
US8815284B2 (en) * | 2003-06-26 | 2014-08-26 | Psivida Us, Inc. | Bioerodible sustained release drug delivery systems |
MX2007006214A (es) * | 2004-11-24 | 2008-04-16 | Therakine Ltd | Un implante para suministro de farmaco intraocular. |
CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
US20100318193A1 (en) | 2007-03-08 | 2010-12-16 | Desai Tejal A | Topographically engineered structures and methods for using the same in regenerative medicine applications |
EP3000434A1 (en) | 2007-03-16 | 2016-03-30 | The Regents Of The University Of California | Nanostructure surface coated medical implants and methods of using the same |
US8623395B2 (en) * | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
SG173167A1 (en) * | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
CN101559041B (zh) * | 2009-05-19 | 2014-01-15 | 中国科学院过程工程研究所 | 粒径均一的多肽药物缓释微球或微囊制剂及制备方法 |
US8417452B2 (en) | 2009-08-19 | 2013-04-09 | General Motors Llc | System for providing information to an operator of a vehicle |
EP2600930B1 (en) | 2010-08-05 | 2021-02-17 | ForSight Vision4, Inc. | Injector apparatus for drug delivery |
JP5907966B2 (ja) * | 2010-08-05 | 2016-04-26 | フォーサイト・ビジョン フォー・インコーポレーテッド | 埋め込み型治療デバイス |
US10864158B2 (en) | 2011-04-14 | 2020-12-15 | The Regents Of The University Of California | Multilayer thin film drug delivery device and methods of making and using the same |
IN2014DN10765A (ru) | 2012-05-30 | 2015-09-04 | Univ California | |
WO2014039964A2 (en) | 2012-09-10 | 2014-03-13 | The Regents Of The University Of California | Compounds and methods for modulating vascular injury |
WO2016010924A1 (en) * | 2014-07-14 | 2016-01-21 | Amgen Inc. | Crystalline antibody formulations |
KR101808234B1 (ko) | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
EA036623B1 (ru) | 2015-10-16 | 2020-12-01 | Ридженерон Фармасьютикалз, Инк. | Стабильные белковые композиции |
-
2016
- 2016-10-14 EA EA201890979A patent/EA036623B1/ru unknown
- 2016-10-14 WO PCT/US2016/057019 patent/WO2017066554A1/en active Application Filing
- 2016-10-14 JP JP2018519460A patent/JP6853245B2/ja active Active
- 2016-10-14 MY MYPI2018701358A patent/MY193964A/en unknown
- 2016-10-14 KR KR1020187013253A patent/KR20180063311A/ko not_active Application Discontinuation
- 2016-10-14 CN CN201680067420.9A patent/CN108348462B/zh active Active
- 2016-10-14 IL IL310557A patent/IL310557A/en unknown
- 2016-10-14 CN CN202111110779.9A patent/CN113827704B/zh active Active
- 2016-10-14 CA CA3001346A patent/CA3001346A1/en active Pending
- 2016-10-14 MX MX2018004695A patent/MX2018004695A/es unknown
- 2016-10-14 EP EP16788338.8A patent/EP3362041A1/en active Pending
- 2016-10-14 US US15/766,586 patent/US20180289623A1/en active Pending
- 2016-10-14 AU AU2016340072A patent/AU2016340072B2/en active Active
-
2018
- 2018-04-09 IL IL258570A patent/IL258570B2/en unknown
- 2018-04-16 MX MX2022003376A patent/MX2022003376A/es unknown
-
2021
- 2021-03-11 JP JP2021038817A patent/JP7179112B2/ja active Active
-
2022
- 2022-01-25 AU AU2022200475A patent/AU2022200475B2/en active Active
- 2022-11-15 JP JP2022182235A patent/JP2023025046A/ja active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11291636B2 (en) | 2011-11-18 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
US11951216B2 (en) | 2011-11-18 | 2024-04-09 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
Also Published As
Publication number | Publication date |
---|---|
IL258570B2 (en) | 2024-07-01 |
JP2023025046A (ja) | 2023-02-21 |
WO2017066554A1 (en) | 2017-04-20 |
CN113827704B (zh) | 2024-07-12 |
EP3362041A1 (en) | 2018-08-22 |
AU2016340072B2 (en) | 2021-10-28 |
KR20180063311A (ko) | 2018-06-11 |
IL258570A (en) | 2018-05-31 |
JP7179112B2 (ja) | 2022-11-28 |
JP6853245B2 (ja) | 2021-03-31 |
EA036623B1 (ru) | 2020-12-01 |
AU2022200475A1 (en) | 2022-02-17 |
AU2022200475B2 (en) | 2023-09-14 |
MY193964A (en) | 2022-11-03 |
CN108348462B (zh) | 2021-10-15 |
BR112018007507A2 (pt) | 2018-10-23 |
JP2018538243A (ja) | 2018-12-27 |
CA3001346A1 (en) | 2017-04-20 |
MX2018004695A (es) | 2019-03-14 |
JP2021098742A (ja) | 2021-07-01 |
MX2022003376A (es) | 2022-04-12 |
AU2016340072A1 (en) | 2018-05-10 |
CN113827704A (zh) | 2021-12-24 |
IL310557A (en) | 2024-03-01 |
IL258570B1 (en) | 2024-03-01 |
US20180289623A1 (en) | 2018-10-11 |
CN108348462A (zh) | 2018-07-31 |
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