MX2018004695A - Composiciones de proteinas estables. - Google Patents
Composiciones de proteinas estables.Info
- Publication number
- MX2018004695A MX2018004695A MX2018004695A MX2018004695A MX2018004695A MX 2018004695 A MX2018004695 A MX 2018004695A MX 2018004695 A MX2018004695 A MX 2018004695A MX 2018004695 A MX2018004695 A MX 2018004695A MX 2018004695 A MX2018004695 A MX 2018004695A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic biomolecule
- reservoir
- biomolecule
- therapeutic
- porous structure
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 abstract 5
- 238000012377 drug delivery Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Abstract
Se describen formulaciones farmacéuticas estables y dispositivos de suministro de fármacos. En determinadas modalidades, el dispositivo de suministro de fármacos contiene un depósito cuando se implanta en un paciente que se encuentra en contacto parcial con el entorno del tejido. El depósito permanece en contacto con el entorno a través de una estructura porosa en el alojamiento del dispositivo de suministro. El depósito contiene una combinación de la biomolécula terapéutica y una segunda molécula que funciona para estabilizar y restringir la solubilidad de la biomolécula terapéutica, mediante lo cual se controla la cantidad de biomolécula terapéutica que se encuentra en solución. La concentración de la biomolécula terapéutica soluble o el tamaño del área de superficie de la estructura porosa controla la velocidad de suministro de la biomolécula terapéutica al tejido diana.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562242412P | 2015-10-16 | 2015-10-16 | |
PCT/US2016/057019 WO2017066554A1 (en) | 2015-10-16 | 2016-10-14 | Stable protein compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018004695A true MX2018004695A (es) | 2019-03-14 |
Family
ID=57209897
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018004695A MX2018004695A (es) | 2015-10-16 | 2016-10-14 | Composiciones de proteinas estables. |
MX2022003376A MX2022003376A (es) | 2015-10-16 | 2018-04-16 | Composiciones de proteinas estables. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022003376A MX2022003376A (es) | 2015-10-16 | 2018-04-16 | Composiciones de proteinas estables. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20180289623A1 (es) |
EP (1) | EP3362041A1 (es) |
JP (3) | JP6853245B2 (es) |
KR (1) | KR20180063311A (es) |
CN (2) | CN113827704A (es) |
AU (2) | AU2016340072B2 (es) |
CA (1) | CA3001346A1 (es) |
EA (1) | EA036623B1 (es) |
IL (2) | IL258570B1 (es) |
MX (2) | MX2018004695A (es) |
MY (1) | MY193964A (es) |
WO (1) | WO2017066554A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11291636B2 (en) | 2011-11-18 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3001346A1 (en) * | 2015-10-16 | 2017-04-20 | Regeneron Pharmaceuticals, Inc. | Stable protein compositions |
AU2018368466A1 (en) * | 2017-11-17 | 2020-06-18 | Amgen Inc. | VEGFR-Fc fusion protein formulations |
JP7235770B2 (ja) | 2018-05-10 | 2023-03-08 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 高濃度vegf受容体融合タンパク質を含む製剤 |
EP3851096A4 (en) * | 2018-09-10 | 2022-07-06 | Samsung Bioepis Co., Ltd. | LIQUID COMPOSITION COMPRISING A PROTEIN |
CN112294760A (zh) * | 2019-07-26 | 2021-02-02 | 张晋宇 | 一种液体制剂及其应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5018693A (en) * | 1992-09-21 | 1994-04-12 | Upjohn Company, The | Sustained-release protein formulations |
US6004549A (en) * | 1994-12-14 | 1999-12-21 | Schering Corporation | Crystalline protein controlled release compositions |
CA2512052C (en) * | 2002-12-31 | 2016-06-21 | Altus Pharmaceuticals Inc. | Human growth hormone crystals and methods for preparing them |
ATE536861T1 (de) * | 2003-06-26 | 2011-12-15 | Control Delivery Sys Inc | Bioerodierbare arzneimittelabgabesysteme mit verzögerter freisetzung |
WO2006057859A1 (en) * | 2004-11-24 | 2006-06-01 | Therakine Corporation | An implant for intraocular drug delivery |
LT2944306T (lt) * | 2006-06-16 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Vfgf antagonisto kompozicijos, tinkamos įvedimui intravitrealiniu būdu |
US20100318193A1 (en) | 2007-03-08 | 2010-12-16 | Desai Tejal A | Topographically engineered structures and methods for using the same in regenerative medicine applications |
EP2164425B1 (en) | 2007-03-16 | 2015-10-28 | The Regents of The University of California | Nanostructure surface coated medical implants and methods of using the same |
PL2391419T3 (pl) * | 2009-01-29 | 2019-12-31 | Forsight Vision4, Inc. | Dostarczanie leku do tylnego odcinka |
US8623395B2 (en) * | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
CN101559041B (zh) * | 2009-05-19 | 2014-01-15 | 中国科学院过程工程研究所 | 粒径均一的多肽药物缓释微球或微囊制剂及制备方法 |
US8417452B2 (en) | 2009-08-19 | 2013-04-09 | General Motors Llc | System for providing information to an operator of a vehicle |
EP3861969A1 (en) | 2010-08-05 | 2021-08-11 | ForSight Vision4, Inc. | Injector apparatus for drug delivery |
SI2600812T1 (sl) | 2010-08-05 | 2021-12-31 | ForSight Vision4, Inc., | Naprava za zdravljenje očesa |
SG194155A1 (en) | 2011-04-14 | 2013-11-29 | Univ California | Multilayer thin film drug delivery device and methods of making and using the same |
JP6336442B2 (ja) | 2012-05-30 | 2018-06-06 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性剤送達デバイス及びその製造方法と使用方法 |
WO2014039964A2 (en) | 2012-09-10 | 2014-03-13 | The Regents Of The University Of California | Compounds and methods for modulating vascular injury |
JP6783223B2 (ja) * | 2014-07-14 | 2020-11-11 | アムジェン インコーポレイテッド | 結晶性抗体製剤 |
KR101808234B1 (ko) * | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
CA3001346A1 (en) * | 2015-10-16 | 2017-04-20 | Regeneron Pharmaceuticals, Inc. | Stable protein compositions |
-
2016
- 2016-10-14 CA CA3001346A patent/CA3001346A1/en active Pending
- 2016-10-14 IL IL258570A patent/IL258570B1/en unknown
- 2016-10-14 CN CN202111110779.9A patent/CN113827704A/zh active Pending
- 2016-10-14 WO PCT/US2016/057019 patent/WO2017066554A1/en active Application Filing
- 2016-10-14 AU AU2016340072A patent/AU2016340072B2/en active Active
- 2016-10-14 IL IL310557A patent/IL310557A/en unknown
- 2016-10-14 MX MX2018004695A patent/MX2018004695A/es unknown
- 2016-10-14 CN CN201680067420.9A patent/CN108348462B/zh active Active
- 2016-10-14 JP JP2018519460A patent/JP6853245B2/ja active Active
- 2016-10-14 EA EA201890979A patent/EA036623B1/ru unknown
- 2016-10-14 US US15/766,586 patent/US20180289623A1/en active Pending
- 2016-10-14 KR KR1020187013253A patent/KR20180063311A/ko not_active Application Discontinuation
- 2016-10-14 MY MYPI2018701358A patent/MY193964A/en unknown
- 2016-10-14 EP EP16788338.8A patent/EP3362041A1/en active Pending
-
2018
- 2018-04-16 MX MX2022003376A patent/MX2022003376A/es unknown
-
2021
- 2021-03-11 JP JP2021038817A patent/JP7179112B2/ja active Active
-
2022
- 2022-01-25 AU AU2022200475A patent/AU2022200475B2/en active Active
- 2022-11-15 JP JP2022182235A patent/JP2023025046A/ja active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11291636B2 (en) | 2011-11-18 | 2022-04-05 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
US11951216B2 (en) | 2011-11-18 | 2024-04-09 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
Also Published As
Publication number | Publication date |
---|---|
MY193964A (en) | 2022-11-03 |
IL258570A (en) | 2018-05-31 |
JP2018538243A (ja) | 2018-12-27 |
CA3001346A1 (en) | 2017-04-20 |
WO2017066554A1 (en) | 2017-04-20 |
JP2021098742A (ja) | 2021-07-01 |
CN108348462B (zh) | 2021-10-15 |
CN108348462A (zh) | 2018-07-31 |
AU2022200475B2 (en) | 2023-09-14 |
IL310557A (en) | 2024-03-01 |
IL258570B1 (en) | 2024-03-01 |
JP2023025046A (ja) | 2023-02-21 |
AU2022200475A1 (en) | 2022-02-17 |
EP3362041A1 (en) | 2018-08-22 |
JP7179112B2 (ja) | 2022-11-28 |
EA201890979A1 (ru) | 2018-10-31 |
US20180289623A1 (en) | 2018-10-11 |
CN113827704A (zh) | 2021-12-24 |
KR20180063311A (ko) | 2018-06-11 |
AU2016340072B2 (en) | 2021-10-28 |
AU2016340072A1 (en) | 2018-05-10 |
BR112018007507A2 (pt) | 2018-10-23 |
EA036623B1 (ru) | 2020-12-01 |
JP6853245B2 (ja) | 2021-03-31 |
MX2022003376A (es) | 2022-04-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022003376A (es) | Composiciones de proteinas estables. | |
NZ711546A (en) | Drug delivery devices with drug-permeable component and methods | |
HRP20211415T1 (hr) | Brzodjelujući pripravci inzulina | |
TW200637615A (en) | Therapeutic peptide formulations with improved stability | |
MY191380A (en) | Stabilized fixed dose drug composition having mometasone and olopatadine | |
MY188825A (en) | High-concentration monoclonal antibody formulations | |
JP2014138843A5 (es) | ||
AR094548A1 (es) | Dispersión sólida físicamente estable | |
MX362275B (es) | Co-agonista de peptido similar a glucagon tipo 1 (glp-1) receptor de glucagon de larga duracion, estables para uso medico. | |
WO2013078257A3 (en) | Implantable solid-liquig drug delivery apparatus, formulations, and methods of use | |
WO2015095772A3 (en) | Formulations and methods for targeted ocular delivery of therapeutic agents | |
MX2021012349A (es) | Dispositivos y metodos de unidades multiples para administracion de farmacos. | |
MX2019014942A (es) | Dispositivos de administracion de farmacos bioerosionables. | |
EP4233978A3 (en) | Oral delivery of active drug substances | |
BR112015021446A2 (pt) | métodos cirúrgicos empregando composições de peptídeo amfifílico purificado | |
MX2022009155A (es) | Nuevos profarmacos polimericos de la hormona del crecimiento humana (hgh). | |
MX2017004772A (es) | Composiciones y métodos para la administración fisiológica utilizando cannabidiol. | |
PH12019501363A1 (en) | Insulin containing pharmaceutical compositions | |
EA201692392A1 (ru) | Новая лекарственная форма мелоксикама | |
UA117480C2 (uk) | Лікування цукрового діабету за допомогою складу інсуліну тривалої дії | |
AU2015242791A1 (en) | Drug Delivery Enhancer Comprising Substance For Activating Lysophospholipid Receptors | |
EP2745856A3 (en) | Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof | |
MX2009013183A (es) | Uso de la proteina de fusion taci-ig, tal como atacicept, para la elaboracion de un medicamento para tratar lupus eritematoso. | |
MX2020006886A (es) | Sistema para suministro de medicamento. | |
EA202191570A1 (ru) | Композиции для доставки терапевтических средств, способы их применения и получения |